DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Rcbtb2

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_001164165.1	Gene:	Rcbtb2 / 105670	MGIID:	1917200	Length:	551	Species:	Mus musculus

Alignment Length:	766	Identity:	150/766 - (19%)
Similarity:	248/766 - (32%)	Gaps:	281/766 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ASLELLDEDTRCPLQAICRK--------------CDDDDLATDSQNDVLVWGSNKNYNLGIGNEQ 165
            :||::||.. :.|:.::|.:              ..::.|.|...:::.|.|:|.:..||:|:.|
Mouse    21 SSLKMLDVG-KWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQ 84

  Fly   166 NTNTPQAVDFFRKSNLWLEQVALGAY----HSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKR 226
            :|..|:.:|     :|..:::|..:|    |.:.....|.::..||....:||.|..|....|
Mouse    85 STIEPRRLD-----SLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVP-- 142

  Fly   227 VKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGA 291
            ..:|:.||...:..::....||||||....|||.|.|...|:|....|.|....:....|::|
Mouse   143 CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNK-- 205

  Fly   292 SDLVRVIACDQHSIAYGSRC---------VYVWGAN-QGQFGINSNTPSITVPTLIKLPAKTTIR 346
              :|..|||       |..|         |||||.| .||.|:.|   |...||..::.|...||
Mouse   206 --VVMNIAC-------GQMCSMAVVDTGEVYVWGYNGNGQLGLGS---SGNQPTPCRVAALQGIR 258

  Fly   347 FVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTE 411
            .              :.:...||                                   ..|:||:
Mouse   259 V--------------QRVACGYA-----------------------------------HTLVLTD 274

  Fly   412 TNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKS 476
            ...:|.|..|:.                               |.:..|..:..:.|:..:.||.
Mouse   275 EGQIYAWGANSY-------------------------------GQLGTGNKSNQSYPTPVVVEKD 308

  Fly   477 RGSLDNWQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSLP 541
            |                    :|.|..             |....:|.|..|..|
Mouse   309 R--------------------IIEIAA-------------CHSAHTSAAKTQGGH---------- 330

  Fly   542 RREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLT 606
                                                                    :|: :....
Mouse   331 --------------------------------------------------------VYM-WGQCR 338

  Fly   607 GKMFELILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVR 671
            |:  .:||.| ::.:..|:|...|.      |.|....|...           ||        ..
Mouse   339 GQ--SVILPH-HTHFCCTDDVFACF------ATPAVTWRLLS-----------VE--------PD 375

  Fly   672 DHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSV 736
            ||.....:.::.|      |:|:..|::.:. |||.:.|||.:|..|.|:|......  :|...|
Mouse   376 DHLTVAESLKREF------DNPDTADLKFLV-DGKYIYAHKVLLKIRCEHFRSSLED--SEDDIV 431

  Fly   737 TMEGVPAEYMEPV----LDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDK 797
            .|    :|:..||    |:|||: ||.:...:..:     .::.:...|....|:.:|:..|...
Mouse   432 EM----SEFSYPVFRAFLEYLYT-DNISLSPEEAV-----GLLDLATFYSETRLKKLCQQTIKQG 486

  Fly   798 ISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLK 848
            |.......:|..|..|:.:.|::.|..|...:|:.|.......:.|.:.||
Mouse   487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	6/36 (17%)
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786	2/5 (40%)
		Ank_2	95..>138	CDD:289560	6/36 (17%)
		RCC1	147..195	CDD:278826	14/51 (27%)
		RCC1	199..251	CDD:278826	14/51 (27%)
		BTB	547..>635	CDD:295341	8/87 (9%)
		BTB	684..795	CDD:279045	29/114 (25%)
		BTB	697..798	CDD:197585	27/104 (26%)
		SPOP_C_like	798..>834	CDD:269810	8/35 (23%)
Rcbtb2	NP_001164165.1	RCC1 1. /evidence=ECO:0000255	64..115		14/55 (25%)
		ATS1	<107..335	CDD:227511	73/423 (17%)
		RCC1 2. /evidence=ECO:0000255	117..169		16/53 (30%)
		RCC1 3. /evidence=ECO:0000255	171..222		17/61 (28%)
		RCC1 4. /evidence=ECO:0000255	223..274		20/102 (20%)
		RCC1 5. /evidence=ECO:0000255	276..326		14/113 (12%)
		RCC1 6. /evidence=ECO:0000255	328..382		16/148 (11%)
		BTB_POZ_RCBTB2_CHC1L	374..490	CDD:349663	33/134 (25%)
		BACK_RCBTB2	487..551	CDD:350604	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900