Protein Alignment CG8060 and hectd4

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: XP_009301943.1
• Gene: hectd4 / 101885095
• -ID: -
• Length: 4419
• Species: Danio rerio
• Alignment Length: 1423
• Identity: 270/1423 - (18%)
• Similarity: 438/1423 - (30%)
• Gaps: 534/1423 - (37%)

  Fly    12 TAKC----------RLRQHGNAITAALTKRSIDN--QKLASFIFKTCGNFANILDDLGRSAVHMS 64
            ::||          |.|...::..||||..:|.|  ::..|.:..:||               :|
Zfish   482 SSKCLNELLLSRMSRFRASHSSTLAALTGSAITNPVKEEQSVVNTSCG---------------LS 531

  Fly    65 ASTARYEILEWLLNHGAYINGQDY--------ESGSSPLHRALYYGSIDCAVLLL---------- 111
            ..|.|...:        |:.|...        .:|||.. |:|:.||...:.|.:
Zfish   532 IKTLRKTPM--------YVCGTSLVMLVPTPGVAGSSAT-RSLFGGSSGLSSLKILASSLVFNLA 587

  Fly   112 --RYGASLELLDEDTRCPLQAICRKCDDDDLAT--DSQNDVLVWGSNKNY--------------- 157
              ::...::|:|    .|..::.|......|..  |:.|: |:|..:.:|
Zfish   588 DGQFSNRVDLVD----APGSSLGRGAQVAGLGACYDALNN-LIWTCSSDYMDQWCNPGNQAFHHV 647

  Fly   158 --NLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLG--IGLE 218
              .||:.:..:....:.:|.....:..|..|.....|.|      :|.|.....  .||  ||.:
Zfish   648 CQRLGVSHAISQTKEEMIDTSSVISQLLHHVGAMCIHQL------NLLAASSSL--HLGTFIGKQ 704

  Fly   219 NSLPAPKR---------VKVSSKLSGDS--IQCISV------------SRQH------SLVLTHQ 254
                 |..         |...:.::||:  |:||.|            |.|:      |.:|..|
Zfish   705 -----PMEACHFSSICDVMEKAMVNGDTRIIRCILVVFQVVFQFFNPNSEQNRECVKRSGLLLWQ 764

  Fly   255 -----------------SLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQ 302
                             .|..:.||||.:|  .......|.:|......::.|.|.|..||..:.
Zfish   765 LLMAPPDQIQPEIQKEVCLAISSGLNTLYQ--SESELNNLLKFVFTEGEKNSGLSQLRDVILNNL 827

  Fly   303 HSIAYGSRCVYVWGANQ---GQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKII 364
                          |||   .:||...:........|::...||.:|            ....:|
Zfish   828 --------------ANQLQKNRFGSEDDDHYRLKDELLQCILKTVVR------------ESCLLI 866

  Fly   365 TLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTE----TNVVYLWYEN---- 421
            |.|        :|.:.|||:       .|.::....:.:|:.||..:    :|.:.|..|:
Zfish   867 TKC--------QTVSKEDLQ-------KLLSTVPVVSPSLRYLMAVQNHLLSNTILLHPEDMEDS 916

  Fly   422 -------TQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGS 479
                   |.:......|.:.|  ..|||..|::|:                    ..||:.: .|
Zfish   917 DSSLQGETMKVQELQTSILSL--ALKILVGCDEVL--------------------ETLQQVT-SS 958

  Fly   480 LDNWQDNDQNK-----TEISRE----HVIRIELQRV--PNIDRAT--------------YIFCDE 519
            |.|...:|:..     .::::.    |::.:.|..:  ||:...|              |.
Zfish   959 LINSSISDRETRLRGLEQVTKATMLGHLLPVLLTSLMHPNLQTLTLADALMPQLVQLVLYT---- 1019

  Fly   520 GFSSFAVLQESHTKYF-------RKPSLPRREHSFKKLLHETSD------------------CDA 559
              |..|:|.::|:..|       :..|.|....|| ::|.|..:                  .:.
Zfish  1020 --SQTALLLKTHSPLFVEDSPINQGSSQPSLNDSF-QILEEREEPGFLTGLKIPAPWAAGKTVET 1081

  Fly   560 VHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLTGKMFELILNHIYSSYWPT 624
            ||.|   .|..||.....|     ||    .||     :||.||......::.....||:.  |.
Zfish  1082 VHPV---RDNYKFKDTVHI-----PG----ARC-----LYLRFDPRCSSQYDYDKLVIYAG--PN 1127

  Fly   625 EDDIDCIQQS-----------LGPANPQQRTRTCEMFLPHLEKFQLVELT-KYVQSYVRDHQFPL 677
            .:.....:..           ||...|:.           |.|.:...:| .:.....|:|..|
Zfish  1128 TNSRKVSEYGGNTMGYGSRSVLGTGWPKD-----------LVKVEGDTVTFSFEMRSGREHNTP- 1180

  Fly   678 PNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSVTMEGVP 742
                                       .|.:....|.:.|:             |.|.....|:|
Zfish  1181 ---------------------------DKAMWGFSCTVRAQ-------------ESSEDVSGGLP 1205

  Fly   743 AEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKC---- 803
            .     :.|....|...| |.   :...|||...|..:      :..|..|:..|: :::|
Zfish  1206 F-----LADLALGLSVLA-CA---MLRILYNGPEITRE------EEACHDLLCSKL-LQRCQWQV 1254

  Fly   804 ---------------------GEMLEFAAMYNCKIL--QKGCMDFICQNLSRVLCYRSI----EQ 841
                                 .|..||.  |...||  ..|.:...|..|.|:...:.|    .:
Zfish  1255 EANGAISPALTPSPSPLPLTIDEEREFT--YPSDILAPPPGPIPSACCELPRIHLPQGIMGRLRE 1317

  Fly   842 CDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELL------LSFVDGCD--VDLNYRMDAES 898
            ..|..    ...:|...|.|     |.|  :.:|:.::      |..||...  |:..||.....
Zfish  1318 LSGRA----RPQFRPSIKEV-----IRP--DVMEEVIVSCVIKHLGLVDALQSLVNFQYRESHRE 1371

  Fly   899 KLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGTEVPSSPQDSARSEDKNWSRVVD 963
            :.....|...:..:|           |::|.|.|               |..|..|.| |...||
Zfish  1372 EHNLLCKIMAETFKK-----------INAMERQL---------------QSVAELEQK-WQNEVD 1409

  Fly   964 KKDQKRKLAETALKVNNT--------LKHEDPPTQELVPIERKPLKEQTPPPPS---------HE 1011
            :. |:.||.      |||        .:::....:.|..::..|| :.|.|..:         ||
Zfish  1410 EA-QQGKLE------NNTPFFHDYHFFENKMKELELLCSLKEVPL-DCTDPENAVMALREKFFHE 1466

  Fly  1012 TEPT-------TPLSKSYNLDFS-----------SLTPQSQKLSQKQRKRLSSESKSWRTNNPPL 1058
            ...|       .||:|:..|..|           ::.||.:.||.......:.:|.|...:..|:
Zfish  1467 VNSTLQQQRSVVPLAKTKALVKSLINRSELLLHVTIAPQCKSLSSTPTSTPACKSVSDAKSMAPV 1531

  Fly  1059 VEQSSTPV-----AVPNAWGVTTT---------------PSGSFNDSFT---SPTTGSSTD-PTS 1099
            |:|   ||     :.|:...:..:               ||...:.|||   |.....|.| ||.
Zfish  1532 VKQ---PVFLRSMSAPSDLEMIASSDVEFTHGAQRRRQHPSSHRSSSFTLLQSLVIEDSKDKPTY 1593

  Fly  1100 FANMMRGHATSSTTPTDQSQSFSRILADEKRQRESYERMRNKSLVHTQIEERAIAELR 1157
            ...:.:..|...|||.....|.|.:.|.:.|.|..  |.|.::|||  :.|...|.:|
Zfish  1594 SVLLGQLFAFIGTTPDQTVSSSSFLSAAQTRWRRG--RTRKQALVH--MRELLTAAVR 1647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430	17/109 (16%)
		ANK repeat	56..87	CDD:293786	5/30 (17%)
		ANK repeat	89..121	CDD:293786	9/43 (21%)
		ATS1	140..>355	CDD:444065	54/284 (19%)
		BTB_POZ	543..643	CDD:453885	25/128 (20%)
		BTB2_POZ_IBtk	691..802	CDD:349611	18/110 (16%)
		BACK_IBtk	798..857	CDD:350575	14/89 (16%)
hectd4	XP_009301943.1	SPRY_HECT_like	2413..2568	CDD:293970
		HECTc	4026..4414	CDD:474882