DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8060 and Rcc1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_001184011.1	Gene:	Rcc1 / 100088	MGIID:	1913989	Length:	434	Species:	Mus musculus

Alignment Length:	279	Identity:	66/279 - (23%)
Similarity:	107/279 - (38%)	Gaps:	57/279 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GNAITAALTKRSIDNQKLASFIFKTCGNFANILDDLGRS----AVHMSASTARY----EILEWLL 77
            |::.|||||:   |.:......|:.......:|:.:.:|    .|.:.|...:.    :.|..|.
Mouse   140 GDSHTAALTE---DGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDAPVVKVASGNDHLVMLT 201

  Fly    78 NHGAYIN---GQDYESGSSP-----------LHRALYYGSIDCAVLLLRYGASLELLDEDTRCPL 128
            |.|....   |:..:.|..|           |.|.|    :...|||...|....:..:|..|..
Mouse   202 NDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLL----VPRCVLLKSRGTRGRVRFQDAFCGA 262

  Fly   129 Q---AICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGA 190
            .   ||.|           :..|..:|.:..:.||.....:...||.:..|:.|.......:.|.
Mouse   263 YFTFAISR-----------EGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQ 316

  Fly   191 YHSLFCDKKGHLYAVGHGKGGRLGIG---LENSLPA--PKRVKVSSKLSGDSIQCISVSRQHSLV 250
            :|::..|.:|..|::|..:.||||:|   .|.|:|.  .:...|||...|.|:         ...
Mouse   317 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSSVACGASV---------GYA 372

  Fly   251 LTHQSLVFACGLNTDHQLG 269
            ::....|||.|:.|::|||
Mouse   373 VSKDGRVFAWGMGTNYQLG 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	23/116 (20%)
		ANK repeat	56..87	CDD:293786	8/41 (20%)
		Ank_4	57..111	CDD:290365	15/75 (20%)
		ANK repeat	89..121	CDD:293786	9/42 (21%)
		Ank_2	95..>138	CDD:289560	12/45 (27%)
		RCC1	147..195	CDD:278826	10/47 (21%)
		RCC1	199..251	CDD:278826	16/56 (29%)
		BTB	547..>635	CDD:295341
		BTB	684..795	CDD:279045
		BTB	697..798	CDD:197585
		SPOP_C_like	798..>834	CDD:269810
Rcc1	NP_001184011.1	RCC1	48..95	CDD:278826
		RCC1	98..147	CDD:278826	3/6 (50%)
		RCC1	150..200	CDD:278826	7/49 (14%)
		RCC1_2	187..216	CDD:290274	5/28 (18%)
		RCC1	203..268	CDD:278826	13/68 (19%)
		RCC1	271..322	CDD:278826	10/50 (20%)
		RCC1	325..368	CDD:278826	15/42 (36%)
		RCC1	376..427	CDD:278826	8/16 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900