DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and atg9b

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001307007.1	Gene:	atg9b / 791223	ZFINID:	ZDB-GENE-091111-3	Length:	805	Species:	Danio rerio

Alignment Length:	755	Identity:	314/755 - (41%)
Similarity:	472/755 - (62%)	Gaps:	56/755 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 HDTEHEGEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVLEF 124
            ||  ::.:..|....::|| |||.....|:||::||:||:|:|.:.||:||..:|:.|..::::|
Zfish    14 HD--YDEDSPPGEEDLLIH-VPEGRGDPWHHIKNLDNFFTRIYHFHQKNGFACMVLSEFFELVQF 75

  Fly   125 GFVVWLLAFVMHCVRFDVLFGDTPP-------GGLNPNKTTLSDVMYPTGEC---LANFTWVTYL 179
            .|||....|:.:||.:||||.:...       |.|:.:|.||.|.:.|:.:|   :...:|:.:|
Zfish    76 LFVVTFTTFLFNCVEYDVLFANRAVNHTGQSLGPLDRSKVTLPDAILPSEQCTERIQGNSWIIFL 140

  Fly   180 VVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMCID 244
            :: :|||:...||:|::.::..|.:|::||..||.|:..:|.||||.|||.|:..:|.|..||:.
Zfish   141 LI-MAAIFWVYRLVKVICNVLSYWEIRQFYIKALKIQMDELCNFTWQEVQNRLILLQREHPMCVQ 204

  Fly   245 KESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPFQ 309
            |..|:|||||||:||||||.||::||.|||||..:|..|:|:.|::|:.:|.:.|||.||.|.||
Zfish   205 KRELSELDIYHRILRFKNYTVAMINKSLLPVRLRVPFIGDVIFLTQGLKYNFELILFWGPLSLFQ 269

  Fly   310 NNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALGL 374
            |.|.|..::...:|:.:||::||::||...|:||:|.|.:.|||::|..||||.::::|||:||.
Zfish   270 NKWSLHPKYKRAANRHDLAKQLSRVILLTGLVNLLLCPFVLVWQVLYAFFSYAEVIKREPGSLGA 334

  Fly   375 RTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFSSPLAAVIAKNLLFISGGLLLLILAL 439
            ..||.:|||||||||||||||..||.|.|..|.:|:|:|.|||.||:|||:.|.||.:|.:::||
Zfish   335 HRWSLFGRLYLRHFNELDHELQGRLGRGYKPAAKYMNAFVSPLLAVLAKNVAFFSGSVLAVLIAL 399

  Fly   440 GIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQQAHTT 504
            .:|:|.|..|:|:|..:..||.:..|.|:.||||::|||||||:..:|||:||:|..|:..|:.:
Zfish   400 TVYDEDVLTVQHILTAITVLGVVITVTRSFIPDEHMVWCPEQLLQCVLAHIHYMPDHWQGSANKS 464

  Fly   505 KVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVCSFAQM 569
            :.|.|.:..||:||.::|.|:.||.:|||:|||..|.|::|::.|||.|||.|.|||::||||||
Zfish   465 ETRDEMAQLFQYKAVFILEELLSPIITPFILIFPLRSKSLEIIDFFRNFTVDVAGVGDICSFAQM 529

  Fly   570 DVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKEAKQFL 634
            |:|:||||.|.    .|..|.|:..|..:        .||||:||:.||:.||:||.|:::..|:
Zfish   530 DIRRHGNPQWM----SEGQTEASVYQQAE--------NGKTELSLMHFTIKNPQWQPPQDSSIFI 582

  Fly   635 RGVRE--HAVGELVQAKTSMVQENPLTNSLIS--FGTMGAD---YCSIANSVLTAQVTPQQLEIS 692
            ..::|  |...:...:...::.|.||.:||:|  .|| |.|   ...:|:.||||...|.:
Zfish   583 SHLKEKVHQDAQTGPSTQLLLSEAPLCSSLLSNESGT-GPDNLLASVLAHPVLTASGLPGR---- 642

  Fly   693 QSLRPGLGPVSGGFPVAASDFRQMLQQNLSASVGPLDSMRR---LRLSRA--EGRLEGPTDTLLY 752
              .|..:.|.|     |||....:| .:||:|..|..|..|   |..||.  :|.:.....|:..
Zfish   643 --NRRFISPSS-----AASAAASVL-ASLSSSQQPHASRSRSHTLLPSRQQHDGHMYSSEHTVAD 699

  Fly   753 GLCGVDPRVGSTPLNV-----GVADMCLSALYLHELNQQK 787
            .:...|||:.|...:.     ..|:|.|.|:|:||::|||
Zfish   700 SMSASDPRMLSQSRSALASEFASAEMSLHAIYMHEVHQQK 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	183/353 (52%)
atg9b	NP_001307007.1	APG9	179..533	CDD:282028	183/353 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578091
Domainoid	1	1.000	498	1.000	Domainoid score	I345
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1016
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm26045
orthoMCL	1	0.900	-	-		OOG6_102183
Panther	1	1.100	-	-	O	PTHR13038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900