DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and ATG9A

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001070666.1	Gene:	ATG9A / 79065	HGNCID:	22408	Length:	839	Species:	Homo sapiens

Alignment Length:	847	Identity:	332/847 - (39%)
Similarity:	465/847 - (54%)	Gaps:	135/847 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EHDTEHE------GEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDE 117
            :.|||::      .:..|....:::| |.|..::.|:|||:||.||||:|...||:|||.:::.|
Human     3 QFDTEYQRLEASYSDSPPGEEDLLVH-VAEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGE 66

  Fly   118 MLQVLEFGFVVWLLAFVMHCVRFDVLFGDTPPG-GLNPN---KTTLSDVMYPTGECLA----NFT 174
            :.::::|.|||....|::.||.:|:||.:.... .|:|.   |.||.|...|...|.|    |.:
Human    67 IFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGS 131

  Fly   175 WVTYLVVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQ 239
            .:|.||  ||.::...||:|.:|:|..|.:|..||..||.|..|.|...||.|||.||.:.|.|.
Human   132 LITILV--IAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEH 194

  Fly   240 HMCIDKESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGP 304
            .:||.|..|||||||||:|||:||:|||:||.|||:||.:|..||.|..:||:.:|.:.|||.||
Human   195 QICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEAVFFTRGLKYNFELILFWGP 259

  Fly   305 GSPFQNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEP 369
            ||.|.|.|.|:.|:.....:.|||||||..||.:.:.|.:|.|:|.:||::|..||||.:|::||
Human   260 GSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREP 324

  Fly   370 GALGLRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFSSPLAAVIAKNLLFISGGLLL 434
            ||||.|.||.|||.||||||||:|||.:||||.|..|.:|:|.|.|||..::|||..|.:|.:|.
Human   325 GALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILA 389

  Fly   435 LILALGIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQ 499
            :::||.||:|.|..|||:|..:..||....|||:.|||:::|:|||||:..||||:||:|..|:.
Human   390 VLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQG 454

  Fly   500 QAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVC 564
            .||.::.|.||:..||:||.::|.|:.||.|||.:|||..||:|:|::.|||.|||.|.|||:.|
Human   455 NAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTC 519

  Fly   565 SFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKE 629
            ||||||||:||:|.|....:    |.|:..|..::        ||||:||:.|.:.||.||.|:|
Human   520 SFAQMDVRQHGHPQWLSAGQ----TEASVYQQAED--------GKTELSLMHFAITNPGWQPPRE 572

  Fly   630 AKQFLRGVREH-----AVGELVQAKTSMVQENPLTNSLISFGTMGADYCSIANSVLTA------- 682
            :..||..::|.     |...|.|.  .::.||.|..|:.|..:.......|||.|..:
Human   573 STAFLGFLKEQVQRDGAAASLAQG--GLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPL 635

  Fly   683 ----QVTPQQLEISQSLR------PGLGPVSGGFPVAASDFRQMLQQNLSASVGPLDSMRRLRLS 737
                |.:..:.|::.:||      ||..|.                                  .
Human   636 PRDLQGSRHRAEVASALRSFSPLQPGQAPT----------------------------------G 666

  Fly   738 RAEGRLEGPTDTLLYGLCGVDPRVGSTPLNV-------------GVADMCLSALYLHELNQQKRQ 789
            ||...:.|         .|||.|..|:..:|             ...:|.|.|||:|:|::|:.|
Human   667 RAHSTMTG---------SGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQ 722

  Fly   790 ARQSR-------IDE----AEDER----------PGTSHWP---PRP--PAAPSADTGFGSRHTV 828
            |...|       .||    |.||.          |.::.:|   |||  |...:...||..|:..
Human   723 AEPERHVWHRRESDESGESAPDEGGEGARAPQSIPRSASYPCAAPRPGAPETTALHGGFQRRYGG 787

  Fly   829 IT 830
            ||
Human   788 IT 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	191/353 (54%)
ATG9A	NP_001070666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/16 (19%)
		APG9	37..525	CDD:397984	243/489 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..686		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..839		20/73 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144880
Domainoid	1	1.000	495	1.000	Domainoid score	I362
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1111
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm41989
orthoMCL	1	0.900	-	-		OOG6_102183
Panther	1	1.100	-	-	LDO	PTHR13038
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R112
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890