DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and Atg9b

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_038963994.1	Gene:	Atg9b / 499973	RGDID:	1560887	Length:	930	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	301/871 - (34%)
Similarity:	449/871 - (51%)	Gaps:	124/871 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EHHPSTGQGP-------SKTQDAKANAAAAHLDPLGEHGLEQPLDEHDTEHEGEDTPRNSGVMIH 78
            :.||....||       .:.:|.         ||.|......|:  |..:|:         .::|
  Rat   105 QDHPGLRIGPLIPEQDYERLEDC---------DPEGSQDSSSPV--HGEDHQ---------PLLH 149

  Fly    79 MVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVLEFGFVVWLLAFVMHCVRFDVL 143
             |||..|..|:||::|||||:::|.|.|::||..|:::::.|:.:|.|:|....|::.||.::||
  Rat   150 -VPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNVL 213

  Fly   144 FGDTP-----PGGLNPNKTTLSDVMYPTGEC---LANFTWVTYLVVFIAAIYLGIRLLKMVYHIT 200
            |.:.|     ||.|: :|.||||.:.|:.:|   :.....:.:|:|..|..:| .:||:.|.::.
  Rat   214 FNNQPKNHTRPGPLH-SKVTLSDAILPSAQCAEKIHGSPLLVFLLVLAAGFWL-FQLLRSVCNLF 276

  Fly   201 QYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMCIDKESLTELDIYHRVLRFKNYLV 265
            .|.||:.||..||||...:|.:..|.|||.|:..:|....:|:....|||||::||:||:.||.|
  Rat   277 SYWDIQVFYREALHIPPEELSSVPWAEVQSRLLELQRSGGLCVQPRPLTELDVHHRILRYTNYQV 341

  Fly   266 ALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPFQNNWQLRDEFAVRSNQTELAQR 330
            ||.||.|||.|..:|..|....||||:..|:|.:|||||.|.|:..|:|.:.:.....:..||.|
  Rat   342 ALANKGLLPARCPLPWGGSAAFLSRGLALNVDLLLFRGPFSLFRGGWELPEAYKRSDLRGVLATR 406

  Fly   331 LSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALGLRTWSNYGRLYLRHFNELDHEL 395
            ..:.:|.:|.:||.|:|::..||:::..:|:..:||:||||.|.|.||...||.|||||||.|||
  Rat   407 WRRTVLLLAAVNLALSPLVLAWQVLHAFYSHVELLRREPGAFGARRWSRLARLQLRHFNELPHEL 471

  Fly   396 DARLNRAYDYADRYLNSFS--SPLAAVIAKNLLFISGGLLLLILALGIYEEHVFQVEHLLAILAG 458
            .|||.|||..|..:|.:..  :||.|::|:.|:|.||.|...:|.|.||:|.|..|||:|..:..
  Rat   472 RARLGRAYRPATAFLRAAEPPAPLRALLARQLVFFSGALFAALLVLTIYDEDVLAVEHVLTTMTA 536

  Fly   459 LGAIGVVCRTLIPDENLVWCPEQ-LMTAILAHVHYLPSEWRQQAHTTKVRQEFSNFFQFKAGYLL 522
            ||....|.|:.||:|.......| |:.|.|||:||||.|.......|....:.|...|::|..||
  Rat   537 LGVTATVARSFIPEEQCQGRSSQLLLQAALAHMHYLPEEPGAAGARTSSYWQMSQLLQYRAVSLL 601

  Fly   523 SEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVCSFAQMDVRKHGNPDWQLTSELEE 587
            .|:.||.:||..|:|.|||:|::::.||..|||.|.|||::||||.|||::||:|.|.    .|.
  Rat   602 EELLSPLLTPLFLLFWFRPRALQIIDFFHHFTVDVAGVGDICSFALMDVKRHGHPQWL----SEG 662

  Fly   588 MTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKEAKQFLRGVREHAVGELVQ---AK 649
            .|.|:..|..::        ||||:||:||:|.:|:||.|..:.:||    .|..|.:.|   |.
  Rat   663 QTEASLSQRAED--------GKTELSLMRFSLAHPQWQPPGHSSKFL----GHLRGRVQQDAAAW 715

  Fly   650 TSMVQENPLTNSLISFGTMGADYCSIANSVLTAQVTPQQLEISQSLRPGLGPVSGGFPVAA---- 710
            .:....:|.|..::|..|.......:||.:::.:  |.|.::|.:     .|.    |.||
  Rat   716 GAPSTRSPPTPGVLSDCTSPLPEAFLANLLVSPR--PPQRDLSPT-----APC----PAAATASL 769

  Fly   711 -SDFRQMLQQNLSASVGPLDSMRRLRLSRAEGRLEGPTDTLLYGLCGVDPRVGSTPLNVGVADMC 774
             :...:|.|.....|.|.....:..:|                      |.:.|       |:|.
  Rat   770 LASISRMAQDPSCVSPGGTGGQKLTQL----------------------PELVS-------AEMS 805

  Fly   775 LSALYLHELNQQKRQARQSRIDEAEDERPGTSHWPPRPPAAP-------SADTGFGSR-HTVITS 831
            |.|:|||:|:||::|........:...||.:|   |..|.:|       |:|..|..| .:....
  Rat   806 LHAIYLHQLHQQQQQEVWGEASASSPSRPWSS---PSQPGSPDEEKPSWSSDVIFIPRFQSCFQP 867

  Fly   832 KAA-------ESTPLLGSIRSXQRPE 850
            |.|       ||.| .|.... :|||
  Rat   868 KTAVGHPEGPESVP-KGFPGDHRRPE 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	157/356 (44%)
Atg9b	XP_038963994.1	APG9	157..649	CDD:397984	205/493 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338577
Domainoid	1	1.000	58	1.000	Domainoid score	I10531
eggNOG	1	0.900	-	-		E1_KOG2173
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1072
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm46130
orthoMCL	1	0.900	-	-		OOG6_102183
Panther	1	1.100	-	-	O	PTHR13038
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760