DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and ATG9B

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_011514367.2	Gene:	ATG9B / 285973	HGNCID:	21899	Length:	968	Species:	Homo sapiens

Alignment Length:	883	Identity:	292/883 - (33%)
Similarity:	449/883 - (50%)	Gaps:	136/883 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLAEEAASPFLEHH------PSTGQGPSKTQDAKANAAAAHLDPLGEHGLEQPLDEHDTE----- 63
            ::...:|||....|      |:|   |:.:|....::....:.||......:.|::.|.|
Human   148 AMTPASASPSWGSHSTPPLAPAT---PTPSQQCPQDSPGLRVGPLIPEQDYERLEDCDPEGSQDS 209

  Fly    64 --HEGEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVLEFGF 126
              |..|..|     ::| |||..|..|:||::|||||:::|.|.|::||..|:::::.|:.:|.|
Human   210 PIHGEEQQP-----LLH-VPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIF 268

  Fly   127 VVWLLAFVMHCVRFDVLFGDTPPGGLNP----NKTTLSDVMYPTGEC---LANFTWVTYLVVFIA 184
            :|....|::.||.::|||.:.|.....|    :|.||||.:.|:.:|   :.:...:..|:|..|
Human   269 IVTFTTFLLRCVDYNVLFANQPSNHTRPGPFHSKVTLSDAILPSAQCAERIRSSPLLVLLLVLAA 333

  Fly   185 AIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMCIDKESLT 249
            ..:| ::||:.|.::..|.||:.||..||||...:|.:..|.|||.|:..:|....:|:....||
Human   334 GFWL-VQLLRSVCNLFSYWDIQVFYREALHIPPEELSSVPWAEVQSRLLALQRSGGLCVQPRPLT 397

  Fly   250 ELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPFQNNWQL 314
            ||||:||:||:.||.|||.||.|||.|..:|..|....||||:..|:|.:|||||.|.|:..|:|
Human   398 ELDIHHRILRYTNYQVALANKGLLPARCPLPWGGSAAFLSRGLALNVDLLLFRGPFSLFRGGWEL 462

  Fly   315 RDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALGLRTWSN 379
            ...:.....:..||.|..:.:|.:|.|||.|:|::..||:::..:|:..:||:||||||.|.||.
Human   463 PHAYKRSDQRGALAARWGRTVLLLAALNLALSPLVLAWQVLHVFYSHVELLRREPGALGARGWSR 527

  Fly   380 YGRLYLRHFNELDHELDARLNRAYDYADRYLNSFS--SPLAAVIAKNLLFISGGLLLLILALGIY 442
            ..||.|||||||.|||.|||.|||..|..:|.:.:  :||..::|:.|:|.:|.|...:|.|.:|
Human   528 LARLQLRHFNELPHELRARLARAYRPAAAFLRTAAPPAPLRTLLARQLVFFAGALFAALLVLTVY 592

  Fly   443 EEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWC----PEQLMTAILAHVHYLPSE----WRQ 499
            :|.|..|||:|..:..||....|.|:.||:|.   |    |:.|:...|||:||||.|    .|.
Human   593 DEDVLAVEHVLTAMTALGVTATVARSFIPEEQ---CQGRAPQLLLQTALAHMHYLPEEPGPGGRD 654

  Fly   500 QAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVC 564
            :|:     ::.:...|::|..||.|:.||.:||..|:|.|||:|:|::.||..|||.|.|||::|
Human   655 RAY-----RQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFTVDVAGVGDIC 714

  Fly   565 SFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKE 629
            |||.|||::||:|.|....:    |.|:..|..::        ||||:||:||:|.:|.|:.|..
Human   715 SFALMDVKRHGHPQWLSAGQ----TEASLSQRAED--------GKTELSLMRFSLAHPLWRPPGH 767

  Fly   630 AKQFLRGVREHAVGELVQ---AKTSMVQENPLTNSLISFGTMGADYCSIANSVLTAQVTPQQLEI 691
            :.:||    .|..|.:.|   |..:.....|.|..::|..|.......:||..:...:.|:.|.
Human   768 SSKFL----GHLWGRVQQDAAAWGATSARGPSTPGVLSNCTSPLPEAFLANLFVHPLLPPRDLS- 827

  Fly   692 SQSLRPGLGPVSGGFPVAA-----SDFRQMLQQNLSASVGPLDSMRRLRLSRAEGRLEGPTDTLL 751
                      .:...|.||     :...::.|...|.|.|.....:..:|
Human   828 ----------PTAPCPAAATASLLASISRIAQDPSSVSPGGTGGQKLAQL--------------- 867

  Fly   752 YGLCGVDPRVGSTPLNVGVADMCLSALYLHELNQQKRQ----------------ARQSRIDEAED 800
                   |.:.|       |:|.|..:|||:|:||::|                :..|:....::
Human   868 -------PELAS-------AEMSLHVIYLHQLHQQQQQQEPWGEAAASILSRPCSSPSQPPSPDE 918

  Fly   801 ERPGTSHWPPRPPAAPSADTGFGSRHTVITSKAAESTP 838
            |:|..|.....|.::|....|        |.||....|
Human   919 EKPSWSSDGSSPASSPRQQWG--------TQKARNLFP 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	158/363 (44%)
ATG9B	XP_011514367.2	APG9	367..723	CDD:309294	158/363 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144878
Domainoid	1	1.000	59	1.000	Domainoid score	I10686
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1111
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm41989
orthoMCL	1	0.900	-	-		OOG6_102183
Panther	1	1.100	-	-	O	PTHR13038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.900