Protein Alignment Atg9 and Atg9a

DIOPT Version :10

• Sequence 1: NP_001261023.1
• Gene: Atg9 / 36821
• FlyBaseID: FBgn0034110
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_001003917.2
• Gene: Atg9a / 245860
• MGIID: 2138446
• Length: 839
• Species: Mus musculus
• Alignment Length: 847
• Identity: 330/847 - (38%)
• Similarity: 464/847 - (54%)
• Gaps: 135/847 - (15%)

  Fly    59 EHDTEHE------GEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDE 117
            :.|||::      .:..|....:::| |.|..::.|:|||:||.||||:|...||:|||.:::.|
Mouse     3 QFDTEYQRLEASYSDSPPGEEDLLVH-VAEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGE 66

  Fly   118 MLQVLEFGFVVWLLAFVMHCVRFDVLFGDTPPG-GLNPN---KTTLSDVMYPTGECLA----NFT 174
            |.::::|.|||....|::.||.:|:||.:.... .|:|.   |.||.|...|...|.|    |.:
Mouse    67 MFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGS 131

  Fly   175 WVTYLVVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQ 239
            .:|.||  ||.::...||:|.:|:|..|.:|..||..||.|..|.|...||.|||.||.:.|.|.
Mouse   132 LITILV--IAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEH 194

  Fly   240 HMCIDKESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGP 304
            .:||.|..|||||||||:|||:||:|||:||.|||:||.:|..||||..:||:.:|.:.|||.||
Mouse   195 QICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGP 259

  Fly   305 GSPFQNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEP 369
            ||.|.|.|.|:.|:.....:.|||||||..||.:.:.|.:|.|:|.:||::|..||||.:|::||
Mouse   260 GSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREP 324

  Fly   370 GALGLRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFSSPLAAVIAKNLLFISGGLLL 434
            ||||.|.||.|||.||||||||:|||.:||||.|..|.:|:|.|.|||..::|||..|.:|.:|.
Mouse   325 GALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILA 389

  Fly   435 LILALGIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQ 499
            :::||.||:|.|..|||:|..:..||....|||:.|||:::|:|||||:..||||:||:|..|:.
Mouse   390 VLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQG 454

  Fly   500 QAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVC 564
            .||.::.|.||:..||:||.::|.|:.||.|||.:|||..||:|:|::.|||.|||.|.|||:.|
Mouse   455 NAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTC 519

  Fly   565 SFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKE 629
            ||||||||:||:|.|....:    |.|:..|..::        ||||:||:.|.:.||.||.|:|
Mouse   520 SFAQMDVRQHGHPQWLSGGQ----TEASVYQQAED--------GKTELSLMHFAITNPGWQPPRE 572

  Fly   630 AKQFLRGVREH-----AVGELVQAKTSMVQENPLTNSLISFGTMGADYCSIANSVLTA------- 682
            :..||..::|.     |...|.|.  .::.||.|..|:.|..:.......|||.|..:
Mouse   573 STAFLGFLKEQVQRDGAAAGLAQG--GLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPSL 635

  Fly   683 ----QVTPQQLEISQSLR------PGLGPVSGGFPVAASDFRQMLQQNLSASVGPLDSMRRLRLS 737
                |.:..:.:::.:||      ||..|
Mouse   636 SRDLQGSRHRADVASALRSFSPLQPGAAP------------------------------------ 664

  Fly   738 RAEGRLEGPTDTLLYGLCGVDPRVGSTPLNV-------------GVADMCLSALYLHELNQQKRQ 789
                  :|...:.:.| .|||.|..|:..:|             ...:|.|.|||:|:|::|:.|
Mouse   665 ------QGRVPSTMTG-SGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQTQ 722

  Fly   790 ARQSR-------IDEAEDERP---GTSHWPPRP-------------PAAPSADT---GFGSRHTV 828
            |...|       .||:.:..|   |.....|:|             |.||....   ||..|:..
Mouse   723 AEPERHVWHRRESDESGESAPEEGGEGARAPQPIPRSASYPCATPRPGAPETTALHGGFQRRYGG 787

  Fly   829 IT 830
            ||
Mouse   788 IT 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	ATG9	86..570	CDD:461177	245/491 (50%)
Atg9a	NP_001003917.2	Tyrosine-based sorting signal. /evidence=ECO:0000250|UniProtKB:Q7Z3C6	8..11		0/2 (0%)
		ATG9	37..525	CDD:461177	245/489 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..686		10/71 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	717..839		18/73 (25%)