DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and Atg9b

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001002897.2	Gene:	Atg9b / 213948	MGIID:	2685420	Length:	922	Species:	Mus musculus

Alignment Length:	856	Identity:	294/856 - (34%)
Similarity:	445/856 - (51%)	Gaps:	105/856 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SPHINYRSLAEEAASPFLEHHPS---TGQGPSKTQDAKANAAAAHLDPLGEHGLEQP-------L 57
            :||    ::.....:|..:.||:   |...||....:....|:|...|......:.|       :
Mouse    85 TPH----NVLPTPTTPSTQAHPTMIHTSASPSWGSHSTPPLASATPPPSCPRPQDHPGLRMGPLI 145

  Fly    58 DEHDTEH------EG-EDTP---RNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTV 112
            .|.|.|.      || :|:|   .:...::| |||..|..|:||::|||||:::|.|.|::||..
Mouse   146 PEQDYERLEDCDPEGSQDSPIHGEDHQPLLH-VPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFAC 209

  Fly   113 IVVDEMLQVLEFGFVVWLLAFVMHCVRFDVLFGDTPP-----GGLNPNKTTLSDVMYPTGEC--- 169
            |:::::.|:.:|.|:|....|::.||.::|||.:.|.     |.|: :|.||||.:.|:.:|
Mouse   210 ILLEDVFQLGQFIFIVTFTTFLLRCVDYNVLFNNQPKNHTRRGPLH-SKVTLSDAILPSAQCAEK 273

  Fly   170 LANFTWVTYLVVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRR 234
            :.:...:.:|:|..|..:| .:||:.|.::..|.||:.||..||||...:|.:..|.|||.|:..
Mouse   274 IHDSPLLVFLLVLAAGFWL-FQLLRSVCNLFSYWDIQVFYREALHIPPEELSSVPWAEVQSRLLE 337

  Fly   235 VQAEQHMCIDKESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFI 299
            :|....:|:....|||||::||:||:.||.|||.||.|||.|..:|.......||||:..|:|.:
Mouse   338 LQRSGGLCVQPRPLTELDVHHRILRYTNYQVALANKGLLPARCPLPWGSSAAFLSRGLALNVDLL 402

  Fly   300 LFRGPGSPFQNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANI 364
            |||||.|.|:..|:|.:.:.....:..||.|..:.:|.:|.:||.|:|::..||:::..:|:..:
Mouse   403 LFRGPFSLFRGGWELPEAYKRSDLRGVLANRWRRTVLLLAAVNLALSPLVLAWQVLHAFYSHVEL 467

  Fly   365 LRKEPGALGLRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFS--SPLAAVIAKNLLF 427
            ||:||||.|.|.||...||.|||||||.|||.|||.|||..|..:|.:..  :||.|::|:.|:|
Mouse   468 LRREPGAFGARRWSRLARLQLRHFNELPHELRARLGRAYRPAAAFLRAAEPPAPLRALLARQLVF 532

  Fly   428 ISGGLLLLILALGIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQ-LMTAILAHVH 491
            .||.|...:|.|.||:|.|..|||:|..:..||....|.|:.||:|.......| |:.|.|||:|
Mouse   533 FSGALFAALLVLTIYDEDVLAVEHVLTTMTALGVTATVARSFIPEEQCQGRSSQLLLQAALAHMH 597

  Fly   492 YLPSEWRQQAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVS 556
            |||.|............:.:...|::|..||.|:.||.:||..|:|.|||:|:|::.||..|||.
Mouse   598 YLPEEPGATGARASSYWQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFTVD 662

  Fly   557 VRGVGNVCSFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNN 621
            |.|||::||||.|||::||:|.|.    .|..|.|:..|..::        ||||:||:||:|.:
Mouse   663 VAGVGDICSFALMDVKRHGHPQWL----SEGQTEASLSQRAED--------GKTELSLMRFSLAH 715

  Fly   622 PEWQMPKEAKQFLRGVREHAVGELVQ---AKTSMVQENPLTNSLISFGTMGADYCSIANSVLTAQ 683
            |:||.|..:.:||    .|..|.:.|   |..:....:|.|..::|..|.......:||  |...
Mouse   716 PQWQPPGHSSKFL----GHLRGRVQQDAAAWGAPSTRSPPTPGVLSDCTSPLPEAFLAN--LLVN 774

  Fly   684 VTPQQLEISQSLRPGLGPVSGGFPVAA-----SDFRQMLQQNLSASVGPLDSMRRLRLSRAEGRL 743
            ..|.|.::|.:     .|.    |.||     :...:|:|.....|.|.....:..:|
Mouse   775 PRPPQRDLSPT-----APC----PAAATASLLASISRMVQDPSCVSPGGTGGQKLTQL------- 823

  Fly   744 EGPTDTLLYGLCGVDPRVGSTPLNVGVADMCLSALYLHELNQQKRQARQSRIDEAEDERPGTSHW 808
                           |.:.|       |:|.|.|:|||:|:||::|........:...||.:|
Mouse   824 ---------------PELVS-------AEMSLHAIYLHQLHQQQQQELWGEASASSPSRPWSS-- 864

  Fly   809 PPRPPAAPSAD 819
             |..|.:|..:
Mouse   865 -PSQPGSPDEE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	155/356 (44%)
Atg9b	NP_001002897.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..144		12/62 (19%)
		APG9	322..679	CDD:282028	155/356 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..922		6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834987
Domainoid	1	1.000	59	1.000	Domainoid score	I10707
eggNOG	1	0.900	-	-		E1_KOG2173
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm44040
orthoMCL	1	0.900	-	-		OOG6_102183
Panther	1	1.100	-	-	O	PTHR13038
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760