DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg9 and atg9b

DIOPT Version :9

Sequence 1:	NP_001261023.1	Gene:	Atg9 / 36821	FlyBaseID:	FBgn0034110	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_002943059.2	Gene:	atg9b / 100486160	XenbaseID:	XB-GENE-6257562	Length:	802	Species:	Xenopus tropicalis

Alignment Length:	838	Identity:	321/838 - (38%)
Similarity:	476/838 - (56%)	Gaps:	122/838 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DEHDTEHEGEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVL 122
            |..:....|||.|     ::| ||:..:..|:||::||:||:::|.:.||:||..:|:.:..:::
Frog    15 DFEEDSPPGEDDP-----LVH-VPDAVKDSWHHIKNLDNFFTKIYHFHQKNGFACMVLSDFFELI 73

  Fly   123 EFGFVVWLLAFVMHCVRFDVLFGDTP------PGGLNPNKTTLSDVMYPTGEC---LANFTWVTY 178
            :|.|||....|:.|||.:||||.:.|      .|....||.||:|.:.|..:|   :....|:.:
Frog    74 QFLFVVTFTTFLFHCVEYDVLFANKPVNHTHSGGAPERNKVTLADAILPAQQCALRIQESGWIIF 138

  Fly   179 LVVFIAAIYLGIRLLKMVYHITQYADIKRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMCI 243
            |:| :|||:...||:||...:..|.:|:|||..||.|...:|.||:|.|||.|:..:|.||.||:
Frog   139 LLV-MAAIFWLYRLIKMFCSLLSYWEIRRFYIRALKIPSDELCNFSWQEVQSRLISLQREQPMCV 202

  Fly   244 DKESLTELDIYHRVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPF 308
            .|:.|||||||||:||||||:||::||.||||||.:||.||...|::|:.:|::|:.|.||||.|
Frog   203 HKKELTELDIYHRILRFKNYMVAMVNKSLLPVRFRLPLIGEATFLTQGLKYNMEFLFFWGPGSLF 267

  Fly   309 QNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALG 373
            ||.|.|:.::.....:.||||.|::.|:.:.|.||.|.|.|.|||::|..|||..::::|||:||
Frog   268 QNKWNLQPKYKRLGQRLELAQELNRTIVLLGLANLFLCPFILVWQILYAFFSYTEVIKREPGSLG 332

  Fly   374 LRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFSSPLAAVIAKNLLFISGGLLLLILA 438
            .|.||.||||||||||||.|||.|||:|.|..|.:|:|||:|||.|:.|||:.|.:|.||.:::|
Frog   333 ARRWSLYGRLYLRHFNELTHELQARLSRGYKPATKYMNSFASPLLAIAAKNIAFFAGSLLAVLIA 397

  Fly   439 LGIYEEHVFQVEHLLAILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQQAHT 503
            |.:|:|.|..|:|:|..:..||.:..|.|:.||||::|||||||:..:|||:||:|..|:..||.
Frog   398 LTVYDEDVLTVQHILTAITVLGVMVTVARSFIPDEHMVWCPEQLLQCVLAHIHYMPDHWQGHAHK 462

  Fly   504 TKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVCSFAQ 568
            ::.|.|.:..||:||.::|.|:.||.:|||:|||..|.|::|::.|||.|:|.|.|||::|||||
Frog   463 SETRDELAQLFQYKAVFILEELLSPIITPFILIFSLRHKSLEIIDFFRNFSVEVVGVGDICSFAQ 527

  Fly   569 MDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKEAKQF 633
            ||:|:||||.|.    .|..|:|:..|..:        .||||:||:.|.:.||.||.|.|:..|
Frog   528 MDIRRHGNPQWL----SEGQTQASVYQQAE--------NGKTELSLMHFAITNPHWQPPLESSVF 580

  Fly   634 LRGVREHAVGELVQAKTS--MVQENPLTNSLIS--FGTMGADYCS--IANSVLTAQVTP------ 686
            :..::|....:...|..:  ::.:.|:.:|.:|  .||...:..:  :.:.||||...|
Frog   581 IGHLKEKVQQDAANAPPAQQILCDAPICSSFLSNESGTAPDNLLASVLVHPVLTASGLPTRDRRF 645

  Fly   687 -QQLEISQSLRPGLGPVSG--------GFPVAASDFR--QMLQQ-NLSASVGPLDSMRRLRLSRA 739
             |....:.:....|..:||        |....:|.:|  |.||| ::|.|.....:|.|..|..:
Frog   646 AQPTTTASAAASVLASLSGSQFSGRHLGANAHSSMYRSDQTLQQESMSQSDSQQKNMSRSSLFAS 710

  Fly   740 EGRLEGPTDTLLYGLCGVDPRVGSTPLNVGVADMCLSALYLHELNQ------------------- 785
            |                           ...|:|.|.|:|:||::|
Frog   711 E---------------------------FASAEMSLHAIYMHEVHQNQGITQRPLGMWQASELSP 748

  Fly   786 QKRQARQSRI--------------DEAE-----DERPGTSHWPPRPPAAPSADTGFGS 824
            .:||...:|.              :|.|     |||.     ||:.|:...:.:|..|
Frog   749 HQRQQTATRSGSRSGYRGLQLGGWEEEEQLHKVDERS-----PPQAPSVGPSTSGSNS 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg9	NP_001261023.1	APG9	219..573	CDD:282028	187/353 (53%)
atg9b	XP_002943059.2	APG9	37..529	CDD:367819	237/492 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	515	1.000	Domainoid score	I313
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136671
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1037
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D107563at33208
OrthoFinder	1	1.000	-	-		FOG0002167
OrthoInspector	1	1.000	-	-		otm49216
Panther	1	1.100	-	-	O	PTHR13038
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R112
SonicParanoid	1	1.000	-	-		X1638
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100