DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7747 and PUB49

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_201554.1	Gene:	PUB49 / 836889	AraportID:	AT5G67530	Length:	595	Species:	Arabidopsis thaliana

Alignment Length:	612	Identity:	252/612 - (41%)
Similarity:	351/612 - (57%)	Gaps:	112/612 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKRQHQKDKMYLTYTEWSELYGGKKVESLENDHVKFKRLPFEHCCITMAPYEMPYCDLQGNVFE 65
            |||:||.||:|::|.|||:..:||.|  |.|| ...||.||:..|.:|..|:|.|.|.:.|:|||
plant     1 MGKKQHSKDRMFITKTEWATEWGGAK--SKEN-RTPFKSLPYYCCALTFLPFEDPVCTIDGSVFE 62

  Fly    66 YEAILKFLKTFKVNPITGQKMDSKSLVKLNFHRNANDEYHCPALFKPFSKNSHIVAVATTGNVYC 130
            ...|:.:::.|..:|:||..:..:.|:.|.||:|:..|||||.|.|.|::.:|||||.|||||:|
plant    63 ITTIVPYIRKFGKHPVTGAPLKGEDLIPLIFHKNSEGEYHCPVLNKVFTEFTHIVAVKTTGNVFC 127

  Fly   131 WEAIDQLNIKTKNWKDLVDDTPFQRKDIITIQDPQKLEKYDISTFYHIKKNLRVLTEEEQQERKN 195
            :|||.:|||||||||:|:.:.||.|.|:||||:|..::......|.|:|..|::..||.::...:
plant   128 YEAIKELNIKTKNWKELLTEEPFTRADLITIQNPNAVDGKVTVEFDHVKNGLKIDDEELKKMNSD 192

  Fly   196 PA-----SGRIKTM--------------------------------NLETKETLEQLQQDYQPAE 223
            ||     ||.||.|                                .||::..::::.:..||.:
plant   193 PAYNINVSGDIKHMLADLGTDKAKEIALHGGGGNKARNERAAAIAAILESRSKIKEVSKAEQPKQ 257

  Fly   224 -------------------EEASTSKRTA---------------DKFNAAHYSTGAVAASFTSTA 254
                               .:|.:|.:||               .|...:.||:||.:.||||:|
plant   258 TYSVVDAASASVFGRSADAAKAGSSDKTAARIAMHMAGDRTPVNSKMVKSRYSSGAASRSFTSSA 322

  Fly   255 MVPVSQIEAAIIDDDLVKYER-VKKKGYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNN 318
            ..||::     .|.:|:|.|: .||||||:..|..|.||:||.||..||||:|||..|..||||.
plant   323 FTPVTK-----NDFELIKVEKNPKKKGYVQFQTTHGDLNIELHCDIAPRACENFITLCERGYYNG 382

  Fly   319 VMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFIT 383
            |.||||||||::|||||||:|.||||||||.|:||....|.|:||||:|||||||:|||||||:.
plant   383 VAFHRSIRNFMIQGGDPTGTGKGGESIWGKPFKDEPNSKLLHSGRGVVSMANSGPHTNGSQFFVL 447

  Fly   384 YRSCKHLDGKHTIFGKLVGGLDTLQKMENIEVDNKDRPIEDIIIESSQVFVNPFAEAAEQLAKER 448
            |:|..||:.|||:||.:||||.||..|||:.||..|||:|:|.|..:.|||||:.|..|:..||:
plant   448 YKSATHLNYKHTVFGGVVGGLATLAAMENVPVDESDRPLEEIKIIEASVFVNPYTELDEEEEKEK 512

  Fly   449 EEEAAGKEEIVKKEEQQKRMKEPLKVYRE-------------GVGKYLK-LQTVAKKP-----EA 494
            .|         |::.:.|.:::....|..             ||||||| :.:.|.|.     ::
plant   513 AE---------KEKNEDKDIEKIGSWYSNPGSGTTEAGAGGGGVGKYLKAMSSTATKDTKGSLDS 568

  Fly   495 PLTSAQAAKKKK----LANGFGDFSSW 517
            .:::...:||:|    .:.||.|||||
plant   569 DISTIGVSKKRKTTASASTGFKDFSSW 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	91/283 (32%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	101/157 (64%)
PUB49	NP_201554.1	RING	39..101	CDD:302633	20/61 (33%)
PUB49	NP_201554.1	cyclophilin_RING	345..502	CDD:238904	101/156 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	212	1.000	Domainoid score	I781
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8643
Inparanoid	1	1.050	438	1.000	Inparanoid score	I409
OMA	1	1.010	-	-		QHG55274
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	1	1.000	-	-		FOG0005496
OrthoInspector	1	1.000	-	-		oto3357
orthoMCL	1	0.900	-	-		OOG6_102815
Panther	1	1.100	-	-	LDO	PTHR45625
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4446
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840