DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and Ppil4

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_080417.2	Gene:	Ppil4 / 67418	MGIID:	1914668	Length:	492	Species:	Mus musculus

Alignment Length:	234	Identity:	82/234 - (35%)
Similarity:	129/234 - (55%)	Gaps:	20/234 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 VRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIW 346
            |.|.|.||.:.::|:.::.||||.||:|.|...|||..:.|...|:||:|.|||||:|.|||||:
Mouse     3 VLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGESIF 67

  Fly   347 GKK-------FEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITY-RSCKHLDGKHTIFGKLVGG 403
            |:.       ||.|..|.:.|..:|.:||.|:|.:.:||||.||. .:..:|||.||:||::..|
Mouse    68 GQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVTEG 132

  Fly   404 LDTLQKMENIEVDNKDRPIEDIIIESSQVFVNPFAEAAEQLAKEREEEAAGKEEI----VKKEEQ 464
            :|.::|:....||....|.:||.|..:.:..:||.:..:.|..:|..|.. ||::    :..:|:
Mouse   133 MDIVKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPT-KEQLDSGRIGADEE 196

  Fly   465 QKRMK-------EPLKVYREGVGKYLKLQTVAKKPEAPL 496
            ....|       |.:|..:|...:.:.|:.|...|:|.:
Mouse   197 IDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADI 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	68/164 (41%)
Ppil4	NP_080417.2	cyclophilin_RRM	4..161	CDD:238902	65/156 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..188		5/21 (24%)
		RRM	<193..>320	CDD:223796	9/43 (21%)
		RRM_PPIL4	237..319	CDD:240681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..409
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810