DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and Ppil2

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006522510.1	Gene:	Ppil2 / 66053	MGIID:	2447857	Length:	564	Species:	Mus musculus

Alignment Length:	490	Identity:	269/490 - (54%)
Similarity:	369/490 - (75%)	Gaps:	12/490 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKRQHQKDKMYLTYTEWSELYGGKKVESLENDHVKFKRLPFEHCCITMAPYEMPYCDLQGNVFE 65
            ||||||||||||:|..|::..|||:|.:.   ....|:||||:||.:::.|:..|.|..:|.||:
Mouse     1 MGKRQHQKDKMYITCAEYTHFYGGRKPDI---SQTSFRRLPFDHCSLSLQPFVYPVCTPEGVVFD 62

  Fly    66 YEAILKFLKTFKVNPITGQKMDSKSLVKLNFHRNANDEYHCPALFKPFSKNSHIVAVATTGNVYC 130
            ...|:.:||.:..||.||:|:|.|||:||||.:|:..:||||.|:..|:.|:||||:.||||||.
Mouse    63 LLNIVPWLKKYGTNPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYT 127

  Fly   131 WEAIDQLNIKTKNWKDLVDDTPFQRKDIITIQDPQKLEKYDISTFYHIKKNLRVLTEEEQQERKN 195
            :||::|||||.||.:||:.|.||.|:||||:|||..|:|:::|.|:|:|.|:|::..:|::.:::
Mouse   128 YEAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFFHVKNNMRIIDPDEEKAKQD 192

  Fly   196 PASGRIKTMNLETKETLEQLQQDYQPAEEEAST----SKRTADKFNAAHYSTGAVAASFTSTAMV 256
            | |..:|..|.||:|||::|.::::..|..|:|    .|:..|:.||||||||.|:|||||||||
Mouse   193 P-SYYLKNTNSETRETLQELYKEFKGDEILAATMRPPEKKKVDQLNAAHYSTGKVSASFTSTAMV 256

  Fly   257 PVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMF 321
            |.:..|||:||:|:::|:.|||||||||:||.|.|||||.||.||:.|:||||.|...||:..:|
Mouse   257 PETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIF 321

  Fly   322 HRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITYRS 386
            |||||||::|||||||:|:||||.|||.|:|||:|||:|||||||||||||||||.||||||:||
Mouse   322 HRSIRNFVIQGGDPTGTGTGGESFWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRS 386

  Fly   387 CKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIEDIIIESSQVFVNPFAEAAEQLAKERE- 449
            |.:||.||||||::|||.|||..|||:|.|.| |||.|:::|.::.|||:|:.||..|:|:||:
Mouse   387 CAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVLICTTTVFVDPYEEADAQIAQERKK 451

  Fly   450 -EEAAGKEEIVKKEEQQKRMKEPLKVYREGVGKYL 483
             :.....|..||..:.|...:.| :.||:|||||:
Mouse   452 TQHQVDPEAKVKMSQPQPGNQGP-QTYRQGVGKYI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	94/216 (44%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	109/158 (69%)
Ppil2	XP_006522510.1	RING-Ubox_PPIL2	38..110	CDD:319577	32/71 (45%)
		RING_Ubox	100..159	CDD:388418	36/58 (62%)
		U-box domain, a modified RING finger	103..146	CDD:319361	26/42 (62%)
		cyclophilin_RING	281..440	CDD:238904	109/158 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844348
Domainoid	1	1.000	233	1.000	Domainoid score	I2391
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8643
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1012
Isobase	1	0.950	-	0	Normalized mean entropy	S1627
OMA	1	1.010	-	-		QHG55274
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	1	1.000	-	-		FOG0005496
OrthoInspector	1	1.000	-	-		oto94842
orthoMCL	1	0.900	-	-		OOG6_102815
Panther	1	1.100	-	-	LDO	PTHR45625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5118
SonicParanoid	1	1.000	-	-		X4446
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750