DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and ppid

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001002065.1	Gene:	ppid / 415155	ZFINID:	ZDB-GENE-040625-34	Length:	371	Species:	Danio rerio

Alignment Length:	264	Identity:	86/264 - (32%)
Similarity:	130/264 - (49%)	Gaps:	49/264 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 LGPLNLELFCDQTPRACDNFIKHCANG-----------YYNNVMFHRSIRNFIVQGGD-PTGSGS 340
            :|.:..|||.|..|:..:||...|...           ::....|||.|::|::|||| ...:|:
Zfish    29 VGRVVFELFADVVPKTAENFRALCTGEKGVGKSTGKPLHFKGCPFHRIIKSFMIQGGDFSNQNGT 93

  Fly   341 GGESIWGKKFEDE---FKPNLTHTGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVG 402
            |||||:|.|||||   :|    |...|:|||||:||||||||||||.....||||||.:||:::.
Zfish    94 GGESIYGDKFEDENFHYK----HDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVLK 154

  Fly   403 GLDTLQKMENIEVDNKDRPIEDIII---------ESSQVFVN--------PFAEAAEQLAKEREE 450
            |:..::.:|.:|. .:|.|::..:|         :...:.:|        .|.|.:|...|:.::
Zfish   155 GMGVVKMLEAMET-KEDNPVKPCVIAECGEHKAGDDWSIALNDGSGDAYPDFPEDSEVDFKDVDK 218

  Fly   451 EAAGKEEI-------VKKEEQQKRMKEPLKV--YREGVGKYLKLQTVAKKPEAPLTSA---QAAK 503
            ..:..|::       .|.:..|..:|:..|.  |.|..|..:...:..||.|....|.   .||.
Zfish   219 VLSVAEDLKNIGNNFFKAQNWQSAIKKYSKALRYLEMCGNIVDDDSSQKKLEPTALSCILNTAAC 283

  Fly   504 KKKL 507
            |.||
Zfish   284 KLKL 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	66/182 (36%)
ppid	NP_001002065.1	cyclophilin_ABH_like	16..182	CDD:238907	64/157 (41%)
		TPR_11	223..304	CDD:290150	17/65 (26%)
		TPR repeat	223..268	CDD:276809	8/44 (18%)
		TPR_12	271..340	CDD:290160	6/17 (35%)
		TPR repeat	273..303	CDD:276809	6/15 (40%)
		TPR repeat	308..336	CDD:276809
		TPR_1	309..341	CDD:278916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900