DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and cwc27

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_957397.1	Gene:	cwc27 / 394078	ZFINID:	ZDB-GENE-040426-1118	Length:	470	Species:	Danio rerio

Alignment Length:	256	Identity:	95/256 - (37%)
Similarity:	141/256 - (55%)	Gaps:	33/256 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 GYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGES 344
            |.|.|.|:.|.:::||:..:||:||.||::.|..|||:..:|||.:..||||||||||:|:||||
Zfish    13 GKVLLKTSAGDIDIELWSKETPKACRNFVQLCMEGYYDGTIFHRMVPEFIVQGGDPTGTGTGGES 77

  Fly   345 IWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQK 409
            |:|:.|:|||...|....||:::|||:||:.||||||.|......|:.|||||||:.|  ||:..
Zfish    78 IYGRPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTG--DTVYN 140

  Fly   410 M---ENIEVDNKDRPIEDIIIESSQVFVNPFAEAAEQL---AKEREEEAAGK------------- 455
            |   .::..|..:||:....|.|::|..:||.:...:.   .||:.::.|.|
Zfish   141 MLRLADVACDGDERPLNPHKIRSTEVLHSPFDDIIPREIKGKKEKNKDEAKKSQSKATKNFSLLS 205

  Fly   456 --EEIVKKEEQQKRMKEPLKVYREGVGKYLKLQTVAKKPEAPLTSAQAAKKKKLANGFGDF 514
              ||..:.||...::.:.:|      || .|......|.:..|:|.....:.:   |.|||
Zfish   206 FGEEAEEDEEMVNQVSQTMK------GK-SKSSHDLLKDDPKLSSVPVVDRNQ---GEGDF 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	75/160 (47%)
cwc27	NP_957397.1	cyclophilin_CeCYP16-like	8..178	CDD:238906	76/166 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..377		19/95 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820