DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and CG3511

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001286847.1	Gene:	CG3511 / 37926	FlyBaseID:	FBgn0035027	Length:	637	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	114/391 - (29%)
Similarity:	185/391 - (47%)	Gaps:	70/391 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DLQGNVFEYEAILKFLKTF--KVNPITGQKMDSKSLVKLNFHRNANDEYHCPALFKPFSKNSHI- 119
            |.:..||::.. .|.::.|  .::..|..:....:|..:.|.|....|..    .:..::|:.:
  Fly   293 DRKVRVFQFNT-GKLIRVFDEALSTYTQMQQTKHALPNMEFGRRMAAERD----LEKTAQNATLN 352

  Fly   120 VAVATTGNVYCWE---AIDQLNIKTKNWKDLVDDTPFQRKDIITIQDPQKLEKYDISTFY-HIKK 180
            :...:|||...:.   .|..:|:.|.....::..|             ..:....::.|. .||:
  Fly   353 ILFDSTGNFLLYPTMLGIKVINVVTNRCVTILGKT-------------DNIRPLQVALFQGRIKR 404

  Fly   181 NLRVLTEEEQQERKNPASGRIKTMNLET------KET-----LEQLQQDYQPAEEEASTSKRTAD 234
            ....:| .||:..:|||...|  :|..|      |::     ..:|..|.|..:.:....|.:.:
  Fly   405 QKAAIT-MEQEASENPALQNI--LNDPTAFCTAYKKSRFYLYSRRLPSDLQDVDRDIFNEKPSKE 466

  Fly   235 KFNAAHYSTGAVAASFTSTAMVPVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLELFCDQ 299
            ...|                 ||    ||:::       :|:.:.  |.|:|..|.:::.||..:
  Fly   467 DIIA-----------------VP----EASVV-------QRIYEN--VVLHTTKGDIHMRLFFKE 501

  Fly   300 TPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRG 364
            .|:..:||..|..|||||..:|||.|:.|:||.|||||:|:||:||||..|:|||.|:|.|....
  Fly   502 VPKTVENFCVHAKNGYYNGHIFHRVIKGFMVQTGDPTGTGTGGKSIWGSDFKDEFVPSLKHDRPY 566

  Fly   365 VLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIEDIIIE 428
            .:||||:||||||||||||......||.|||:||::..|::.:..:.|.:.:.| |:|.:||.|.
  Fly   567 TVSMANAGPNTNGSQFFITVLPTPWLDNKHTVFGRVYRGMEVVLNICNSKANPKTDKPYDDIKII 631

  Fly   429 S 429
            |
  Fly   632 S 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	35/197 (18%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	73/150 (49%)
CG3511	NP_001286847.1	WD40	<75..>312	CDD:225201	5/19 (26%)
		WD40	<79..300	CDD:295369	2/6 (33%)
		WD40 repeat	85..122	CDD:293791
		WD40 repeat	128..176	CDD:293791
		WD40 repeat	181..210	CDD:293791
		WD40 repeat	218..268	CDD:293791
		WD40 repeat	275..311	CDD:293791	4/18 (22%)
		cyclophilin_WD40	485..633	CDD:238908	72/148 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447186
Domainoid	1	1.000	81	1.000	Domainoid score	I449
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950