DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and Ppil2

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001017383.1	Gene:	Ppil2 / 360746	RGDID:	1309484	Length:	521	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	283/526 - (53%)
Similarity:	387/526 - (73%)	Gaps:	14/526 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKRQHQKDKMYLTYTEWSELYGGKKVESLENDHVKFKRLPFEHCCITMAPYEMPYCDLQGNVFE 65
            ||||||||||||:|..|::..|||:|.:..:   ..|:||||:||.:::.|:..|.|..:|.||:
  Rat     1 MGKRQHQKDKMYITCAEYTHFYGGRKPDITQ---TSFRRLPFDHCSLSLQPFVYPVCTPEGVVFD 62

  Fly    66 YEAILKFLKTFKVNPITGQKMDSKSLVKLNFHRNANDEYHCPALFKPFSKNSHIVAVATTGNVYC 130
            ...|:.:||.:..:|.||:|:|.|||:||||.:|:..:||||.|:..|:.|:||||:.||||||.
  Rat    63 LLNIVPWLKKYGTDPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYT 127

  Fly   131 WEAIDQLNIKTKNWKDLVDDTPFQRKDIITIQDPQKLEKYDISTFYHIKKNLRVLTEEEQQERKN 195
            :||::|||||.||.:||:.|.||.|:||||:|||..|:|:::|:|:|:|.|:|::..:|::.:::
  Rat   128 YEAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSSFFHVKNNMRMIDPDEEKAKQD 192

  Fly   196 PASGRIKTMNLETKETLEQLQQDYQPAEEEAST----SKRTADKFNAAHYSTGAVAASFTSTAMV 256
            | |..:|..|.||:|||::|.::::..|..|:|    .|:..|:.||||||||.|:|||||||||
  Rat   193 P-SYYLKNTNAETRETLQELYKEFKGDEILAATMKPPEKKKVDQLNAAHYSTGKVSASFTSTAMV 256

  Fly   257 PVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMF 321
            |.:..|||:||:|:::|:.|||||||||:||.|.|||||.||.||:.|:||||.|...||:..:|
  Rat   257 PETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIF 321

  Fly   322 HRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITYRS 386
            |||||||::|||||||:|:||||.|||.|:|||:|||:|||||||||||||||||.||||||:||
  Rat   322 HRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRS 386

  Fly   387 CKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIEDIIIESSQVFVNPFAEAAEQLAKERE- 449
            |.:||.||||||::|||.|||..|||:|.|.| |||.|::.|.::.|||:|:.||..|:|:||:
  Rat   387 CAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVRICTTTVFVDPYEEADAQIAQERKK 451

  Fly   450 -EEAAGKEEIVKKEEQQKRMKEPLKVYREGVGKYLK-LQTVAKKPEAPLTS-AQAAKKKKLANGF 511
             :.....|...|..:.|...:.| :.||:|||||:. ..|.....|.|.|| |....||:.:.||
  Rat   452 TQHQVDPEAKAKTNQPQPGNQGP-QTYRQGVGKYINPAATKRAAEEEPSTSTAIPTAKKRPSRGF 515

  Fly   512 GDFSSW 517
            ||||||
  Rat   516 GDFSSW 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	93/216 (43%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	109/158 (69%)
Ppil2	NP_001017383.1	Ubox	42..96	CDD:128780	22/53 (42%)
Ppil2	NP_001017383.1	cyclophilin_RING	281..440	CDD:238904	109/158 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347716
Domainoid	1	1.000	231	1.000	Domainoid score	I2353
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8643
Inparanoid	1	1.050	575	1.000	Inparanoid score	I1008
OMA	1	1.010	-	-		QHG55274
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	1	1.000	-	-		FOG0005496
OrthoInspector	1	1.000	-	-		oto98346
orthoMCL	1	0.900	-	-		OOG6_102815
Panther	1	1.100	-	-	LDO	PTHR45625
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4446
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770