DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and PPIL6

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001104768.2	Gene:	PPIL6 / 285755	HGNCID:	21557	Length:	337	Species:	Homo sapiens

Alignment Length:	221	Identity:	71/221 - (32%)
Similarity:	107/221 - (48%)	Gaps:	45/221 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 SQIEAAIIDDDLVKYERVKKKGYVRL-----NTNLGPLNLELFCDQTPRACDNFIKHCANG---- 314
            |.:..|:.:|...|:.|..|..:|.|     ::.:|.|..||:||..|:.|.||...|...
Human   121 SALYDALTEDFSAKFLRDTKHDFVFLDICIDSSPIGRLIFELYCDVCPKTCKNFQVLCTGKAGFS 185

  Fly   315 ------YYNNVMFHRSIRNFIVQGGDPT-GSGSGGESIWGKKFEDEFKP---------------- 356
                  :|.|.:|||.::|..:||||.. |.|..||||:|..||:.:..
Human   186 QRGIRLHYKNSIFHRIVQNGWIQGGDIVYGKGDNGESIYGPTFEELYGSLKRSVKRQKESRGVGK 250

  Fly   357 ---------NLTHTGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQKMEN 412
                     ::.|..||||.|||.|.::|||||:||.::..:||.|...||:|:.|.:.|:::|.
Human   251 IEKYRDENFSVPHNKRGVLGMANKGRHSNGSQFYITLQATPYLDRKFVAFGQLIEGTEVLKQLEL 315

  Fly   413 IEVDNKDRPIEDIIIESSQVFVNPFA 438
            :...| :|||....|..|.   :|:|
Human   316 VPTQN-ERPIHMCRITDSG---DPYA 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	65/199 (33%)
PPIL6	NP_001104768.2	cyclophilin	144..333	CDD:412213	62/189 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810