DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7747 and Ppwd1

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_766395.2	Gene:	Ppwd1 / 238831	MGIID:	2443069	Length:	646	Species:	Mus musculus

Alignment Length:	445	Identity:	126/445 - (28%)
Similarity:	195/445 - (43%)	Gaps:	122/445 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 YEAILKFLKTFKVNPITGQKMDSKSLVKLNFHRNANDEY----------HCPA-----LFKPFSK 115
            |:|::...|:..:...||...:.|      |.:|.|.||          .|.|     .|.|..|
Mouse   235 YKAVVSSDKSGMIEYWTGPPHEYK------FPKNVNWEYKTDTDLYEFAKCKAYPTSICFSPDGK 293

  Fly   116 NSHIVAVATTGN---VYCWEAI---------DQLNIKT--KNWKDLVDDTPFQRKDIITIQDPQK 166
            .     :||.|:   |..:..:         :.|::.|  :..:..:.|..|.|:..:    .::
Mouse   294 K-----IATIGSDRKVRIFRFLTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAV----ERE 349

  Fly   167 LEKYD-----------------ISTFYHIK-------KNLRVLTEEEQQE-----------RKNP 196
            |||.|                 ..|...||       :.:|:|.::|...           :|:.
Mouse   350 LEKVDAVRLVNIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHR 414

  Fly   197 ASGRIKTMNLETKETLEQLQQD------------------YQPAEEEASTSKRTADKFNAAHYST 243
            |:..|: |.......|:.:|.|                  .:|  |:..|:....|.||......
Mouse   415 AAATIE-MKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREP--EDTKTADSDRDVFNEKPSKE 476

  Fly   244 GAVAASFTSTAMVPVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLELFCDQTPRACDNFI 308
            ..:||   :.|..|....::||:                  :|::|.::::||..:.|:..:||.
Mouse   477 EVMAA---TQAEGPKRVSDSAIV------------------HTSMGDIHIKLFPVECPKTVENFC 520

  Fly   309 KHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANSGP 373
            .|..|||||...|||.|:.|::|.|||||:|.|||||||.:|||||...|.|.....|||||:|.
Mouse   521 VHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGS 585

  Fly   374 NTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIEDIII 427
            ||||||||||......||.|||:||::..|::.:|::.|::|:.| |:|.||:.|
Mouse   586 NTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSI 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	47/253 (19%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	72/148 (49%)
Ppwd1	NP_766395.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		WD 1	88..126
		WD40	89..>318	CDD:295369	20/93 (22%)
		WD40	<89..311	CDD:225201	20/86 (23%)
		WD 2	131..170
		WD40 repeat	136..177	CDD:293791
		WD40 repeat	191..219	CDD:293791
		WD 3	221..260		6/30 (20%)
		WD40 repeat	226..277	CDD:293791	11/47 (23%)
		WD 4	278..319		9/45 (20%)
		WD40 repeat	283..326	CDD:293791	8/47 (17%)
		cyclophilin_WD40	495..643	CDD:238908	73/164 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920