DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7747 and PPWD1

DIOPT Version :9

Sequence 1:NP_611113.1 Gene:CG7747 / 36820 FlyBaseID:FBgn0034109 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_056157.1 Gene:PPWD1 / 23398 HGNCID:28954 Length:646 Species:Homo sapiens


Alignment Length:445 Identity:127/445 - (28%)
Similarity:196/445 - (44%) Gaps:122/445 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 YEAILKFLKTFKVNPITGQKMDSKSLVKLNFHRNANDEY----------HCPA-----LFKPFSK 115
            |:|::...|:..:...||...:.|      |.:|.|.||          .|.|     .|.|..|
Human   235 YKAVVSSDKSGMIEYWTGPPHEYK------FPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGK 293

  Fly   116 NSHIVAVATTGN---VYCWEAI---------DQLNIKT--KNWKDLVDDTPFQRKDIITIQDPQK 166
            .     :||.|:   |..:..:         :.|::.|  :..:..:.|..|.|:..:    .::
Human   294 K-----IATIGSDRKVRIFRFVTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAV----ERE 349

  Fly   167 LEKYD-----------------ISTFYHIK-------KNLRVLTEEEQQE-----------RKNP 196
            |||.|                 ..|...||       :.:|:|.::|...           :|:.
Human   350 LEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHR 414

  Fly   197 ASGRIKTMNLETKETLEQLQQD------------------YQPAEEEASTSKRTADKFNAAHYST 243
            |:..|: |.......|:.:|.|                  .:|.:.:::.|.|  |.||......
Human   415 AATTIE-MKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDR--DVFNEKPSKE 476

  Fly   244 GAVAASFTSTAMVPVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLELFCDQTPRACDNFI 308
            ..:||   :.|..|....::|||                  :|::|.::.:||..:.|:..:||.
Human   477 EVMAA---TQAEGPKRVSDSAII------------------HTSMGDIHTKLFPVECPKTVENFC 520

  Fly   309 KHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANSGP 373
            .|..|||||...|||.|:.|::|.|||||:|.|||||||.:|||||...|.|.....|||||:|.
Human   521 VHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGS 585

  Fly   374 NTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIEDIII 427
            ||||||||||......||.|||:||::..|::.:|::.|::|:.| |:|.||:.|
Human   586 NTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSI 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7747NP_611113.1 RING 25..238 CDD:302633 47/253 (19%)
cyclophilin_RING 281..439 CDD:238904 72/148 (49%)
PPWD1NP_056157.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
WD 1 80..118
WD40 89..>318 CDD:421866 20/93 (22%)
WD 2 124..162
WD40 repeat 136..177 CDD:293791
WD 3 168..208
WD40 repeat 191..219 CDD:293791
WD 4 213..252 3/16 (19%)
WD40 repeat 226..277 CDD:293791 11/47 (23%)
WD 5 271..309 9/42 (21%)
WD40 repeat 283..326 CDD:293791 8/47 (17%)
WD 6 345..386 7/44 (16%)
WD 7 401..453 7/52 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..490 10/39 (26%)
cyclophilin_WD40 495..643 CDD:238908 74/164 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1392223at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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