DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and cyn-15

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_493378.1	Gene:	cyn-15 / 173225	WormBaseID:	WBGene00000891	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	141/567 - (24%)
Similarity:	215/567 - (37%)	Gaps:	184/567 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKVESLENDHVKFKRL---PFEHCCITMAPYEMPYCDLQGNVFEYEAILKFLKTFKVNPITGQKM 86
            ||..|...:.||..|.   .|.|.|..:..      .|...|.|.:   |.:|.|.:     :..
Worm    81 KKKHSEGVEFVKHFRCHLSEFSHICANIDG------TLLATVCEAD---KSVKVFDI-----ENF 131

  Fly    87 DSKSLVKLNF-HRNAN-------------------------------------DEYH-CPALFKP 112
            |..:::||:| .:.||                                     |:.| .|.....
Worm   132 DMINMIKLDFPPKTANWVHQSNDPIAHLAIGAADSGKIIVVDGKATAAPICIKDKLHSTPVKIIE 196

  Fly   113 FSKN-SHIVAVATTGNVYCW--EAIDQLNIKTK-NWK-----DLVDDTPFQRKDIITIQDP---- 164
            :|:: ..||::..:|.:.||  |..|....:|| .|:     ||.|....:...:....||
Worm   197 YSQSLDIIVSIDESGMIECWNGERGDFQFPETKLTWEYKLETDLYDFVKAKTIPVCATFDPSGLK 261

  Fly   165 -------QKLEKYDIST-------------------------FYHIKKNLRVLTEEE-QQERKN- 195
                   :|:..:::.|                         ..|::.:.|:.:|:| .:::||
Worm   262 LATFAEDRKIRIFNVKTGKLAQLIDETTQKYHCEAKENKNYGLQHMEWSRRLASEKEMDKDKKNS 326

  Fly   196 -----------------PASGRIKTMNLETKETLEQLQQDYQPAEEEASTSKRTAD---KFNAAH 240
                             |....:|..||.|.|....:.:|........|......|   |...|.
Worm   327 LKYTKICFDQSGNFLLYPTPIGVKVFNLVTNEVSRTIGRDEAIRFVAVSLCNALPDIRQKLQGAA 391

  Fly   241 YSTGAVAAS--------------------------FTSTAMVPVSQIEAAIIDDDL--------- 270
            .:....||.                          ||:|        |...::||.
Worm   392 ITLETAAADNPTLNRKTDPDPLMVCCALRKNRFYLFTNT--------EPYNVEDDEGNPSVSGRD 448

  Fly   271 VKYERVKKKGYVR----------------LNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNV 319
            |..||.||:..:.                ::|:.|.:.:.||.|:.|:..:||..|...||||.:
Worm   449 VFNERPKKEDLLTALDTEGGEKVLNKEAIIHTSFGDITIRLFGDECPKTVENFCTHSRRGYYNGL 513

  Fly   320 MFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTHTGRGVLSMANS-GPNTNGSQFFIT 383
            .|||.|::|::|.|||:|.|:|||||||:.|||||.|.|.|.....:||||: |.||||||||||
Worm   514 TFHRVIKSFMIQTGDPSGKGTGGESIWGEDFEDEFHPRLRHDKPFKVSMANAGGGNTNGSQFFIT 578

  Fly   384 YRSCKHLDGKHTIFGKLVGGLDTLQKMENIEV-DNKDRPIEDIIIES 429
            ......||||:|:||::..|:..:|::..:.. :...||.|.|.|.|
Worm   579 VCPADWLDGKNTLFGEVTAGMSVVQRINQVSTFERSGRPRESIQIMS 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	58/321 (18%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	69/167 (41%)
cyn-15	NP_493378.1	WD40	53..>285	CDD:392136	42/217 (19%)
		WD40 repeat	101..142	CDD:293791	12/54 (22%)
		WD40 repeat	150..185	CDD:293791	0/34 (0%)
		WD40 repeat	192..237	CDD:293791	11/44 (25%)
		cyclophilin	477..626	CDD:381853	69/149 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920