DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and PPIE

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001181936.1	Gene:	PPIE / 10450	HGNCID:	9258	Length:	314	Species:	Homo sapiens

Alignment Length:	160	Identity:	70/160 - (43%)
Similarity:	96/160 - (60%)	Gaps:	13/160 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 DDLVKYERVKKKGYVRL---NTNLGPLNLELFCDQTPRACDNFIKHCAN--GY-YNNVMFHRSIR 326
            :.:.|..|...:.|:.:   |...|.:.:.|..|..|...:||...|.:  |: :....|||.|.
Human   130 EPIAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIP 194

  Fly   327 NFIVQGGDPTG-SGSGGESIWGKKFEDEFKPN--LTHTGRGVLSMANSGPNTNGSQFFITYRSCK 388
            .|:.||||.|. :|:||:||:||||:||   |  |.|||.|:||||||||||||||||:|.....
Human   195 QFMCQGGDFTNHNGTGGKSIYGKKFDDE---NFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTD 256

  Fly   389 HLDGKHTIFGKLVGGLDTLQKMENIEVDNK 418
            .|||||.:||::..|||.|:::| :..|.|
Human   257 WLDGKHVVFGEVTEGLDVLRQIE-VAPDTK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	68/147 (46%)
PPIE	NP_001181936.1	RRM	<5..>84	CDD:223796
		RRM_PPIE	8..80	CDD:240793
		cyclophilin_ABH_like	140..279	CDD:238907	65/141 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900