DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7747 and CWC27

DIOPT Version :9

Sequence 1:NP_611113.1 Gene:CG7747 / 36820 FlyBaseID:FBgn0034109 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_005860.2 Gene:CWC27 / 10283 HGNCID:10664 Length:472 Species:Homo sapiens


Alignment Length:246 Identity:96/246 - (39%)
Similarity:139/246 - (56%) Gaps:32/246 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 GYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGES 344
            |.|.|.|..|.:::||:..:.|:||.|||:.|...||:|.:|||.:..||||||||||:||||||
Human    13 GKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGSGGES 77

  Fly   345 IWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQK 409
            |:|..|:|||...|....||:::|||:|.:.||||||.|......|:.|||||||:.|  ||:..
Human    78 IYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKVTG--DTVYN 140

  Fly   410 M---ENIEVDNKDRPIEDIIIESSQVFVNPFAE----AAEQLAKEREEEAAGK------------ 455
            |   ..:::|:.:||.....|:|.:|..|||.:    ..::|.||:.||...|            
Human   141 MLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTKNFSLL 205

  Fly   456 ---EEIVKKEEQQKRMKEPLKVYREGVGKYLK----LQTV----AKKPEAP 495
               ||..::||:..|:.:.:|...:.....||    |.:|    ::|.:||
Human   206 SFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAP 256

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7747NP_611113.1 RING 25..238 CDD:302633
cyclophilin_RING 281..439 CDD:238904 76/160 (48%)
CWC27NP_005860.2 cyclophilin_CeCYP16-like 8..178 CDD:238906 77/166 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..386 13/51 (25%)
DUF5401 <302..>472 CDD:375164
CWC27_CTD 376..428 CDD:412084
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..472
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0652
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1392223at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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