Protein Alignment CG7747 and CWC27

DIOPT Version :10

• Sequence 1: NP_611113.1
• Gene: CG7747 / 36820
• FlyBaseID: FBgn0034109
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_005860.2
• Gene: CWC27 / 10283
• HGNCID: 10664
• Length: 472
• Species: Homo sapiens
• Alignment Length: 246
• Identity: 96/246 - (39%)
• Similarity: 139/246 - (56%)
• Gaps: 32/246 - (13%)

  Fly   280 GYVRLNTNLGPLNLELFCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGES 344
            |.|.|.|..|.:::||:..:.|:||.|||:.|...||:|.:|||.:..||||||||||:||||||
Human    13 GKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGSGGES 77

  Fly   345 IWGKKFEDEFKPNLTHTGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQK 409
            |:|..|:|||...|....||:::|||:|.:.||||||.|......|:.|||||||:.|  ||:..
Human    78 IYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKVTG--DTVYN 140

  Fly   410 M---ENIEVDNKDRPIEDIIIESSQVFVNPFAE----AAEQLAKEREEEAAGK------------ 455
            |   ..:::|:.:||.....|:|.:|..|||.:    ..::|.||:.||...|
Human   141 MLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTKNFSLL 205

  Fly   456 ---EEIVKKEEQQKRMKEPLKVYREGVGKYLK----LQTV----AKKPEAP 495
               ||..::||:..|:.:.:|...:.....||    |.:|    ::|.:||
Human   206 SFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAP 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING-Ubox_PPIL2	41..113	CDD:438325
		RING_Ubox	104..162	CDD:473075
		cyclophilin_RING	281..439	CDD:238904	76/160 (48%)
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	77/166 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..386		13/51 (25%)
		DUF5401	<302..>472	CDD:375164
		CWC27_CTD	376..428	CDD:412084
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..472