DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7747 and ppwd1

DIOPT Version :9

Sequence 1:	NP_611113.1	Gene:	CG7747 / 36820	FlyBaseID:	FBgn0034109	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001092228.1	Gene:	ppwd1 / 100000660	ZFINID:	ZDB-GENE-070615-16	Length:	622	Species:	Danio rerio

Alignment Length:	328	Identity:	106/328 - (32%)
Similarity:	163/328 - (49%)	Gaps:	63/328 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 FSKNSHIVAVATTGNVYCWEAIDQLNIKTKNWKDLVDDTPFQRKDIITIQDPQKLEKYDISTFYH 177
            |.:..|.|...|      ...|..:|::|.....::.    ::::|..:|         :|.|..
Zfish   339 FDETGHFVLYGT------MLGIKVINVETNRCVRILG----KQENIRVVQ---------LSLFQG 384

  Fly   178 IKKNLRVLTEEEQQERKNPASGRIKTMNLETKE-------TLEQLQQDY-----QPAEEEASTSK 230
            :.|.::.....|.:..:|||        |::.:       |..:..:.|     :|.:.:::.|.
Zfish   385 VAKAMQAAPTIEMKASENPA--------LQSSDPDPTIFCTAFKKNRFYMFTKREPEDTKSADSD 441

  Fly   231 RTADKFNAAHYSTGAVAASFTSTAMVPVSQIEAAIIDDDLVKYERVKKKGYVRLNTNLGPLNLEL 295
            |  |.||........:||   :.|..|....::|||                  :|.:|.::::|
Zfish   442 R--DIFNEKPSKEEVMAA---TQAEGPKRVSDSAII------------------HTTMGDIHIKL 483

  Fly   296 FCDQTPRACDNFIKHCANGYYNNVMFHRSIRNFIVQGGDPTGSGSGGESIWGKKFEDEFKPNLTH 360
            |..:.|:..:||..|..|||||..:|||.|:.|::|.|||||:|.|||||||.:|||||...|.|
Zfish   484 FPVECPKTVENFCVHSRNGYYNGHIFHRVIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRH 548

  Fly   361 TGRGVLSMANSGPNTNGSQFFITYRSCKHLDGKHTIFGKLVGGLDTLQKMENIEVDNK-DRPIED 424
            .....|||||:||.|||||||||......||.|||:||:...|::.:|::.||:|:.| |:|.||
Zfish   549 DRPYTLSMANAGPGTNGSQFFITVVPTPWLDNKHTVFGRTSKGMEVVQRISNIKVNPKTDKPYED 613

  Fly   425 III 427
            |.|
Zfish   614 ISI 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7747	NP_611113.1	RING	25..238	CDD:302633	24/136 (18%)
CG7747	NP_611113.1	cyclophilin_RING	281..439	CDD:238904	74/148 (50%)
ppwd1	NP_001092228.1	WD40	64..294	CDD:295369
		WD40	<64..287	CDD:225201
		WD40 repeat	69..107	CDD:293791
		WD40 repeat	112..161	CDD:293791
		WD40 repeat	167..195	CDD:293791
		WD40 repeat	202..253	CDD:293791
		WD40 repeat	259..302	CDD:293791
		cyclophilin_WD40	471..619	CDD:238908	76/164 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920