Protein Alignment ITGAE and ItgaPS5

DIOPT Version :10

• Sequence 1: NP_002199.3
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1179
• Species: Homo sapiens
• Sequence 2: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 235/1064 - (22%)
• Similarity: 392/1064 - (36%)
• Gaps: 280/1064 - (26%)

Human   262 VMASLARVQN-ITQVGSVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVL---TDGGI------- 315
            :.....|.|: :...||:.:|.:..:..|.|...|.:....|.:|....|   .|||.
  Fly    58 IFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLL 122

Human   316 -----FEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMAL 375
                 |..|.|.    |..:|:|:..:......:.......|.::||.|..:|
  Fly   123 VCAPRFFVPKNK----NYGQMRGICYWVRDTVADTPPLSDVRTISLIPSQAEE------------ 171

Human   376 DGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQ-VLLGAVGAFDWSGGALLYDTRSRR 439
                                  |:.| ::|.||.:.|:.. .|:||.|...|.|..|::     |
  Fly   172 ----------------------HFML-ELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVH-----R 208

Human   440 GRFLNQTAAAAA------DAEAAQYSYLGYAVA----VLHKTCSLSYIAGAP-RYKHHGAVFELQ 493
            |..|....:.|.      |.....::|:|||::    ..:...||.|:..|| ...:.|..:...
  Fly   209 GEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFD 273

Human   494 KEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPF------YHVHGEEGRVYVYR 552
            ..|.....|.|..|||:|.|||..:...|::.||.|| ::|:||.      |.|    |.:||:
  Fly   274 VVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDV----GAIYVF- 332

Human   553 LSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYI 617
              ...|.|...:.:...|..:.||||.:::.:||::.|...|:|:|||..|.||        |:|
  Fly   333 --INKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGA--------VFI 387

Human   618 YNGHWDGLSASPSQRIRASTVAP---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSR 677
            :.|...||...||||:.|.:..|   |...||..::.|.||.|:|..|:.:|..|...|  :|:.
  Fly   388 FLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAY 452

Human   678 PVVRLKV-----SMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQR 737
            |||::..     |.|..|.      ...:.|..|:.:.:.:.|.:...:|.....|:|    :..
  Fly   453 PVVKIHATVRSESRAIRPE------QETITVTACYRLETTSKARQMQQQELTFRMTID----ELL 507

Human   738 RRLQCSDVRS----------CLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQL- 791
            :|:..:.:|:          ..|..|.:|.|...        |.|      .|:...:::.|:|
  Fly   508 QRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHY--------TGG------IFTPIDLELHYELA 558

Human   792 -QTPEGQTDHPQ--PILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELT 853
             :.|.......:  .::|.....:|...|.:...|...: ||::|||::.......:.|..:.|:
  Fly   559 KKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAAHV-CVSDLQLSSKDVNSSFIFGSLEVLS 622

Human   854 LNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVL---- 914
            .:..:|||||.:|:...                   |:......|.|.| ..|||:.|.|:
  Fly   623 FSYEITNSGEPAYVAQF-------------------NVTSSARLPFAKV-PGNCRVRHEVMLCDL 667

Human   915 -------KRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFRH--------- 963
                   :..|..:::::.:.:.:..:.|.:..|:....::.......:.|:..|.
  Fly   668 NGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGG 732

Human   964 ---GFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVP--------------- 1010
               |.:|:...|....||        ..:.|..||.::.. |..:.:.||
  Fly   733 PIDGHIALKEYPYSAEVN--------NSYEFKSHGPSIID-ELTVYVDVPIAYTVTGSAGIKSIF 788

Human  1011 -------TKLRGLQVVAVKKLTRTQASTVCTWSQERACAYSSVQ--------HVEEWHSVSCVIA 1060
                   ....|.::|.:|...:|.     |.::|.....||.:        ..:::..:..|..
  Fly   789 NISSLQMQATHGSELVPIKLYDQTN-----TLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNI 848

Human  1061 SD---KENVTVAAEISWD----------HSEELLKDVTELQILGEISFNKSLYEGLNA------- 1105
            ||   |||:.....:..|          .|:..::...|..|...|||...|.:.:|.
  Fly   849 SDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIF 913

Human  1106 -------ENHRTKI--------TVVFLKDEKYHSLPI--IIKGSVGGLLVLIVILVILFKCGFFK 1153
                   |...|.|        .|:|...|.  .|||  ||...:.|.|:|..:..||:|..|||
  Fly   914 TNVEMFKEGDSTSIALKRNLKPNVIFNYSET--PLPIWYIILSLIAGHLLLGAMTYILYKLRFFK 976

Human  1154 RKYQQLNLESIRKAQLKSENLLEE 1177
            |.         :|.:||  .||||
  Fly   977 RG---------KKEELK--RLLEE 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAE	NP_002199.3	FG-GAP 1	22..79
		FG-GAP 2	80..138
		X-domain (extra domain)	145..199
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..200
		vWA_integrins_alpha_subunit	201..378	CDD:238746	25/131 (19%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..442		15/52 (29%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	447..499		13/62 (21%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	500..560		23/65 (35%)
		Int_alpha	510..561	CDD:214549	18/56 (32%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	563..627		21/63 (33%)
		Int_alpha	574..633	CDD:214549	23/58 (40%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	631..691		22/69 (32%)
		Int_alpha	643..>678	CDD:214549	12/36 (33%)
		Integrin_alpha2	677..>951	CDD:462478	53/303 (17%)
		GFFKR motif	1150..1154		2/3 (67%)
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	14/42 (33%)
		Int_alpha	351..403	CDD:214549	23/59 (39%)
		Int_alpha	417..463	CDD:214549	15/45 (33%)
		Integrin_alpha2	453..837	CDD:462478	74/442 (17%)