Protein Alignment ITGAE and ItgaPS4

DIOPT Version :10

• Sequence 1: NP_002199.3
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1179
• Species: Homo sapiens
• Sequence 2: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Alignment Length: 958
• Identity: 217/958 - (22%)
• Similarity: 354/958 - (36%)
• Gaps: 282/958 - (29%)

Human   398 HYQLAQIGFSAQILDER-QVLLGAVGAFDWSGGALLYDT---------RSRRG----RFLNQTAA 448
            :|.:.::|.||.:.|:. ::|:||.|...|.|...|...         |.|||    |..|:...
  Fly   192 YYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNP 256

Human   449 AAADAEAAQYSYLGYAVAV-LHKTCSLS---YIAGAPR------------------YKHHGAVFE 491
            ...:....::||.||||:. ...:.:||   |:|.|||                  ||:|
  Fly   257 EPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYH----- 316

Human   492 LQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHG--EEGRVYVYRLS 554
                        ...|...|.|||..:...|::.||.|| ::::||.|.:..  ::|.:||:
  Fly   317 ------------EFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVF--- 365

Human   555 EQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYN 619
            ...|||:....:...|..:..|||..::.:||:::|...|||:|||..|        .|||:||.
  Fly   366 INKGSFTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAG--------NGSVFIYL 422

Human   620 GHWDGLSASPSQRIRASTVAP---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSRPV 679
            |..:||...|||.:.|.:..|   |...||..::.|.||.|:|..|..:|......|  :|:.||
  Fly   423 GSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 487

Human   680 VRLKVSMAFTPSALPIG-FNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCS 743
            |  |:.....|....:. ....||:.:|:.:||.:.:....|.|..|...:|:|. |.:.:|...
  Fly   488 V--KIHAIIKPKLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDIDT-KSKIKLAVF 549

Human   744 DVRSCLGCLREWSSGSQ-----------LCEDLLL----------------------MPTEGELC 775
            |.          ..|||           :|.:..:                      :|..|:.|
  Fly   550 DE----------EHGSQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFC 604

Human   776 EEDCFSNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS 840
             |||                       .::|.....|....:.:...|...: |||:|:::...:
  Fly   605 -EDC-----------------------AVVDPAEPKFVTEYITFNTGCATDV-CVADLKISCINA 644

Human   841 QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIM 905
            ...||:|.|..|.|..|:||:||.:|....::.....|.|  .|.|.:..:.       .:|::.
  Fly   645 SSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSL--AQVPGNCKVN-------EAVMVC 700

Human   906 NCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANE--THTLQFRHGFVAV 968
            :...|..:.|..:..:::.:.:.:  ...|:.:|...|.::.:..:..|.  |:.|..|
  Fly   701 DLNHGQRMAKGDTDSLTISFDVRQ--LRGRSLEIQAEVLSARDESNPENNKLTNVLSLR------ 757

Human   969 LSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAE----YQLQICVPTKLRGLQV-----VAVKKL 1024
              :.:.:||:..|...|      .|..|:.:.||    |:::...|:.|..|.|     ||.|..
  Fly   758 --EKADIYVSGVQTNDH------VVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTP 814

Human  1025 TRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELL-------- 1081
            ..|....:.|.|.:....|:        |.:..:...|:.| .:|...:.||.:..|
  Fly   815 DSTNVKHIVTSSPKIQSKYA--------HKIMPINFIDQNN-ALANNFAIDHDQSTLLFSATPQH 870

Human  1082 KDVTELQILGEISFNKS---LYEGLNAEN------HRTKITV----------------------- 1114
            ::|..|.  |.:..|.|   |.|.|...|      ..|.:|:
  Fly   871 ENVGNLS--GIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMT 933

Human  1115 ----VFLKDE-------------KYHSL--PI-------------------------IIKGSVGG 1135
                |.|||.             |.|.:  |.                         ||...:.|
  Fly   934 VSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVG 998

Human  1136 LLVLIVILVILFKCGFFKR----KYQQLNLESIRKAQLKSENLLEEEN 1179
            :||.......|:|.|||||    ..:||..:|.....:::|   .|||
  Fly   999 ILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTE---MEEN 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAE	NP_002199.3	FG-GAP 1	22..79
		FG-GAP 2	80..138
		X-domain (extra domain)	145..199
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..200
		vWA_integrins_alpha_subunit	201..378	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..442		16/57 (28%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	447..499		16/73 (22%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	500..560		17/61 (28%)
		Int_alpha	510..561	CDD:214549	17/52 (33%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	563..627		22/63 (35%)
		Int_alpha	574..633	CDD:214549	24/58 (41%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	631..691		19/64 (30%)
		Int_alpha	643..>678	CDD:214549	11/36 (31%)
		Integrin_alpha2	677..>951	CDD:462478	57/307 (19%)
		GFFKR motif	1150..1154		3/3 (100%)
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	23/76 (30%)
		Int_alpha	384..434	CDD:214549	22/57 (39%)
		Int_alpha	447..>492	CDD:214549	16/46 (35%)
		Integrin_alpha2	486..808	CDD:462478	74/384 (19%)