Protein Alignment ITGAE and scb

DIOPT Version :10

• Sequence 1: NP_002199.3
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1179
• Species: Homo sapiens
• Sequence 2: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Alignment Length: 1016
• Identity: 233/1016 - (22%)
• Similarity: 391/1016 - (38%)
• Gaps: 269/1016 - (26%)

Human   355 NLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDA-LHYQLAQIGFSAQILDER-QVL 417
            |.:||.|..     ||....|     :|:...:..|.....| ..|.:.::|.||.:.|:. :.|
  Fly   167 NTVASTPQH-----VTRISPL-----RLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFL 221

Human   418 LGAVGAFDWSGGALLY--------DTRSRR--GRFLNQTAAAAADAEAAQY-------------- 458
            :||.|...|.|..:||        .|.|||  .:.|.:|   ..|.::..|
  Fly   222 IGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRT---YRDVDSNDYTPEHYAPEIPTPGL 283

Human   459 ------SYLGYAVAV----LHKTCSLSYIAGAPR-YKHHGAVFELQKEGREASFLPVLEGEQMGS 512
                  ||.||||:.    ......|.|:|.||: .|..|..:.....|:......|..|||.|.
  Fly   284 WGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGE 348

Human   513 YFGSELCPVDIDMDGSTDFLLVAAPFYHVHG--EEGRVYVYRLSEQDGSFSLARILSGHPGFTNA 575
            |||..:...|::.||.|| ::|:||.:.:..  :.|.:||:   ...|.|:..|.:...|..|.|
  Fly   349 YFGYSVLAEDLNGDGKTD-VIVSAPQHALEDSHDNGAIYVF---INKGFFNFERQILRSPVETMA 409

Human   576 RFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAP 640
            |||.|::.:||::.|...|||:|||..|        .|:|:||.|..:||...||||:.|.:..|
  Fly   410 RFGTALSRLGDINHDGYNDVAVGAPFAG--------NGTVFIYLGSENGLRDQPSQRLDAPSQQP 466

Human   641 ---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSRPVVRLKV-----SMAFTPSALPI 695
               |...||..::.|.||.|:|..|..:|......|  :|:.|||::..     |....|.
  Fly   467 SKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPE---- 527

Human   696 GFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQ 760
              ...|.:..|:.:|  ||:::..::|..|...:.:|  ||.:|::.:..::.....:..::..:
  Fly   528 --QEKVKITACYRLS--TTSTDKLVQEQELAIRIAMD--KQLKRVKFTQTQTNEISFKVNANFGE 586

Human   761 LCEDLLLMPTEGELCEEDCFSNASVKVSYQL--QTPEGQTDHPQPILDRYTEPFAIFQ-LPYEKA 822
            .|.|   ..|:....|:|.|:...:::.|:|  :.|:.:.......:...|||....| :.:...
  Fly   587 QCRD---FETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTG 648

Human   823 CKNKLFCVAELQLATTVSQQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPP 887
            |...: |.|:|||.:.......::|....|.||..:||.||.:|:..  .|.....:|...|.|.
  Fly   649 CATDV-CTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQ--FNVTSTSRLAFAQVPG 710

Human   888 SPNIQCDDPQPVASVLIMNCRIGHPVLKRSSAHVSV---VWQL----------------EENAFP 933
            :..:       |.:|::.:...|.|:.|..:..|::   |.||                |:|...
  Fly   711 NCKV-------VDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTD 768

Human   934 NRT---------ADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQGLSHHKEF 989
            ||.         .:|..:...:|.:..|.:.:::.:..:.:....:.||::...|   :|.:...
  Fly   769 NRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLT---VSFYIPI 830

Human   990 LFHVHGENL-----------FGAEYQLQIC------------------VPTKLRGLQVVAVKKLT 1025
            .:.|.|...           ..|.|..|:.                  |.|.|.|    .:::..
  Fly   831 AYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSG----GLERTV 891

Human  1026 RTQ---------------------ASTVCT--WSQERACAYSSVQHVEEWHSVSCVIASD----- 1062
            .||                     .|.|.|  .|::|....:...:.|::..:|.|.|.|
  Fly   892 ITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDD 956

Human  1063 ------------------KENVTVAAEI-----------------------------SWDHSEEL 1080
                              :..:.|.||:                             .|::. .:
  Fly   957 FKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYF-VI 1020

Human  1081 LKDVTELQILGE-----ISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLP--IIIKGSVGGLLV 1138
            |.|: :||..|:     .|.|:.:...:.:::..|             .||  |||...:||||:
  Fly  1021 LTDL-KLQKKGDPTSTSFSINRRIEPNIISKHQET-------------GLPIWIIIVSVIGGLLL 1071

Human  1139 LIVILVILFKCGFFKR-KYQQLNLESIRKAQLKSENLLEEE 1178
            |..|..:|:|.|||.| |..:|:       :|..:|.:|.|
  Fly  1072 LSAISYLLYKFGFFNRTKKDELD-------RLVQQNPVEPE 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAE	NP_002199.3	FG-GAP 1	22..79
		FG-GAP 2	80..138
		X-domain (extra domain)	145..199
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..200
		vWA_integrins_alpha_subunit	201..378	CDD:238746	7/22 (32%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..442		19/63 (30%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	447..499		16/76 (21%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	500..560		20/61 (33%)
		Int_alpha	510..561	CDD:214549	16/52 (31%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	563..627		25/63 (40%)
		Int_alpha	574..633	CDD:214549	25/58 (43%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	631..691		20/69 (29%)
		Int_alpha	643..>678	CDD:214549	11/36 (31%)
		Integrin_alpha2	677..>951	CDD:462478	63/309 (20%)
		GFFKR motif	1150..1154		3/3 (100%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549
		FG-GAP	350..388	CDD:460357	12/38 (32%)
		Int_alpha	409..459	CDD:214549	25/57 (44%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	509..829	CDD:462478	68/345 (20%)