DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGAE and if

DIOPT Version :9

Sequence 1:XP_024306508.1 Gene:ITGAE / 3682 HGNCID:6147 Length:1217 Species:Homo sapiens
Sequence 2:NP_001162777.1 Gene:if / 32661 FlyBaseID:FBgn0001250 Length:1396 Species:Drosophila melanogaster


Alignment Length:1052 Identity:221/1052 - (21%)
Similarity:375/1052 - (35%) Gaps:306/1052 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   305 VLDSIFTSSHGSR---------RKASKVM----VVLTDG--GIFEDPLNLTTVINSPKMQGVERF 354
            :|..|..|:||..         |::|..|    :.:..|  |.:.:..|::.::.:||.. ..|:
  Fly    21 ILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFD-TSRY 84

Human   355 AIGV---GEEFKSARTARELNLIASDPD-----------ETHAFKVTNYMALDGLLSKL------ 399
            ..||   |..||.:....:..|:..|..           :..:::........|..|.|      
  Fly    85 QQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAP 149

Human   400 RYNIISMEGT-------VGDAL-------HYQLA---------------QIGFSAQIL-DERQVL 434
            ||...:|..:       ||...       .|:::               |.||||.|. :..::.
  Fly   150 RYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLF 214

Human   435 LGAVGAFDWSGGAL-------------LYDTRSRRG--------RFLNQTAAAAADAEAAQYSYL 478
            :||.|::.|.|...             ||......|        |..||..:.:..|.....|||
  Fly   215 IGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYL 279

Human   479 GYAVAV--LHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPV----------LEGEQMGSYF 531
            ||::..  .....|.....|.||            .|.....:.|          :.|.|:|.||
  Fly   280 GYSMVTGDFDGDRSEDVAIGMPR------------GGNLVGRIVVNRWNMANIFNITGRQIGEYF 332

Human   532 GSELCPVDIDMDGSTDFLLVAAPFY----HVHG--EEGRVYVYRLSEQDGSFSLARILSGH--PG 588
            |..|...|:|.||..| ||:.||.|    :|.|  :.||||:..   |.|.....|..:.|  .|
  Fly   333 GYSLATSDVDGDGLDD-LLIGAPMYTDPDNVEGKYDVGRVYILL---QGGPTEEKRWTTEHIRDG 393

Human   589 F-TNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRA 652
            : :..|||.|:..:||::.|...|.|:|||.:|   .:|.  |.|||::|...|..|.|||.|::
  Fly   394 YHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDG---PEGR--GVVYIFHGSPMGPLAKPSQIIKS 453

Human   653 STVAPGLQY---FGMSMAGGFDISGDGLADITVGTLG--QAVVFRSRPVVRLKVSMAFTPSALPI 712
            ..:..|..|   ||.:::||.|:.|:...|:.||...  |..:|:||||..:....:|..::..|
  Fly   454 EQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLI 518

Human   713 GFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWS-SGS 776
            ..:.    |.|                         .:.:..:::.|..:.:|      || :|.
  Fly   519 SLDD----RSC-------------------------QLVRDHKKVPCMLLTTC------WSYTGR 548

Human   777 QLCEDL------------LLMP------TEG--------------ELC----------EEDCFSN 799
            .|.|.|            ||.|      .||              :.|          .:|..:.
  Fly   549 YLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTP 613

Human   800 ASVKVSYQLQTP---EGQTDHP----QPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS 857
            ..|:..|.|::.   :....|.    :|::|:..|......:..:|.|.....|..:|:|..:..
  Fly   614 LEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTV 678

Human   858 QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQ----KPPSPNIQCDDPQPVAS 918
            .:.| .|..:.|.:.:.::|:.||::..:..:..|.:||.:::|    |..:| |.|..|.| .:
  Fly   679 DKYL-FGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTP-ITCSPPTP-EN 740

Human   919 VLIMNCRIGHPVLKRSSVSRF--GLIRSSHHPAVGVFCILAHVSVVWQ-----LEE--NAFPNR- 973
            ...:.|.||:| |:...::.|  .|:....:.:...:      ...|:     ||:  :.:.|: 
  Fly   741 NHTLKCDIGNP-LESGKIAHFKISLVPEEKYGSSSSY------DFYWEANSTNLEKPGSEYDNKI 798

Human   974 --------TADITVTVTN--------SNERRSLANET----------HTLQFRHGFVAVLSKPSI 1012
                    ..|:.:..|:        :::.:.|.|.|          |..:.|:      ::|||
  Fly   799 RQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRN------NRPSI 857

Human  1013 MYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQI----------CVPTKLRGLQVVAVKKLTR--- 1064
            :         ...|...|:..|.:.|......:          |.........::..:||.:   
  Fly   858 I---------EEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSY 913

Human  1065 TQASTVCTWSQERACAYSSVQ--------HVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKD 1121
            .||.. ..|:..:....||..        |:|:......|......|.|.|.:.......|..:.
  Fly   914 LQAQG-AIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQ 977

Human  1122 VTELQILGEISF 1133
            ...|:.||:.||
  Fly   978 EDTLEALGDASF 989

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAEXP_024306508.1 vWA_integrins_alpha_subunit 218..395 CDD:238746 21/118 (18%)
Int_alpha 527..578 CDD:214549 23/56 (41%)
Int_alpha 591..650 CDD:214549 24/58 (41%)
Int_alpha 660..>695 CDD:214549 13/39 (33%)
Integrin_alpha2 693..>942 CDD:312071 57/304 (19%)
ifNP_001162777.1 Int_alpha 46..110 CDD:214549 14/64 (22%)
Int_alpha 275..>316 CDD:214549 11/52 (21%)
Int_alpha 398..451 CDD:214549 24/57 (42%)
Int_alpha 466..>497 CDD:214549 10/30 (33%)
Integrin_alpha2 499..893 CDD:285619 76/453 (17%)
DUF2756 <1120..1178 CDD:298627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141990
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D743479at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

Return to query results.
Submit another query.