Protein Alignment ITGAE and mew

DIOPT Version :10

• Sequence 1: NP_002199.3
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1179
• Species: Homo sapiens
• Sequence 2: NP_001285196.1
• Gene: mew / 32275
• FlyBaseID: FBgn0004456
• Length: 1243
• Species: Drosophila melanogaster
• Alignment Length: 966
• Identity: 230/966 - (23%)
• Similarity: 373/966 - (38%)
• Gaps: 263/966 - (27%)

Human   399 YQLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAA------AAADAEAAQ 457
            |.|.|.|.||.:||:..::||:.|.:.|.|...:...   .|.:|.:...      :..::...:
  Fly   202 YGLCQAGTSAALLDDDTMVLGSPGPYTWRGSIWVTQV---GGEYLQRDKTTYYSDHSDLNSPVDK 263

Human   458 YSYLGYAVAVLHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPV---LEGEQMGSYFGSELC 519
            |||||.:|........:||.|||||.:.||.|....|.....  :||   |:|||.||.||.||.
  Fly   264 YSYLGMSVTGGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNP--IPVHSILDGEQFGSSFGYELA 326

Human   520 PVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAM 584
            ..||:.|...| |:||||.|....|.|.||||:..:..........|:|.   ..:|||.|:|.:
  Fly   327 TADINGDHRPD-LIVAAPLYFTKTEGGAVYVYQNIQDTLPMKYTLKLTGP---LESRFGLALANI 387

Human   585 GDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRAS----TVAPG--LQ 643
            |||::|...|:|:|||.||.|.        ||||.|...||::.|:|:|:||    |:..|  ::
  Fly   388 GDLNKDNCEDLAVGAPYEGNGV--------VYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIR 444

Human   644 YFGMSMAGGFDISGDGLADITVGTLGQ--AVVFRSRPVVRLKVSM---------AFTPSAL--PI 695
            .||:|::|..|:..:...|:.:|....  ||:..:||::.::.|:         ..||..|  |.
  Fly   445 TFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPNTPGCLDDPA 509

Human   696 GFNGVVNVRLCFEISSVTTASESGLREALLNFTLDV---DVGKQRRRLQCSDVRSCLGCLREWSS 757
            ........|.|..|......:    :|..|.::::.   |..|:..|:...|        || :.
  Fly   510 SNLTCFTFRACCSIEPYDEKN----KELRLAYSVEAETFDHLKKFSRVFFFD--------RE-NK 561

Human   758 GSQLCEDLLLMPTEGEL-CE----------EDCFSNASVKVSYQLQTP---EGQTDHPQPILDRY 808
            .:.:...::.:.|.|.. |:          .|..:....::.|.|..|   :.......||||:
  Fly   562 RTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLNPILDQ- 625

Human   809 TEPFAIFQLPYEKACKNKLFCVAELQL-----ATTVSQQELVVGLTK-ELTLNINLTNSGEDSYM 867
            |:....|:..::|.|.:...|.:.|.:     .|..|..|..:.|.: ||.:.||::|..:.:|.
  Fly   626 TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILDETELEVRINVSNLADSAYE 690

Human   868 TSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVLKRSSAHVSVVWQ---LEE 929
            ..:.:.:...:.....:||  .|..|:.    .:..::.|.:|:|:|:.::..|::.:|   ||.
  Fly   691 AQLFIAHQAGVSYVATKKP--TNATCNS----YNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEP 749

Human   930 -------NAFPNRTA----------DITVTV-------------------TNSNERRSLANETHT 958
                   :.|.|.|:          |:.|.|                   :.|:...|:||...|
  Fly   750 SEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAAT 814

Human   959 --------------LQFRHGFVAVLSKPS---------------------------IMY------ 976
                          .|..|.|......||                           ::|
  Fly   815 DIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPT 879

Human   977 VNTGQGLSH-HKEFLFHVHGENLFGA--EYQLQICVPTKLRGLQVVA----VKKLTRTQASTVCT 1034
            |...||..| .||:   |:..||...  |....:..|.::|.....:    .|.|..:|.|
  Fly   880 VEVSQGECHVAKEY---VNPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRS---- 937

Human  1035 WSQERACAYSSVQHVEEWHSVSC------VIASDKENVTVAAEISWD---------HSEELLK-- 1082
                    |.|..|.:: ||...      |..|..|.||....:.:|         ..:::::
  Fly   938 --------YYSSSHRDD-HSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIVELD 993

Human  1083 -------------DVTELQILGEIS-------FNKSLYE----------------------GLNA 1105
                         |:..:..|.|..       :|.:|..                      |:..
  Fly   994 CNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEV 1058

Human  1106 ENH-----RTKITVVFLKDEKYHSLP--IIIKGSVGGLLVLIVILVILFKCGFFKR 1154
            .:|     .|:........::..|:|  |||.|.|||||:|.::..:|:|.|||||
  Fly  1059 MDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAE	NP_002199.3	FG-GAP 1	22..79
		FG-GAP 2	80..138
		X-domain (extra domain)	145..199
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..200
		vWA_integrins_alpha_subunit	201..378	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	390..442		14/42 (33%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	447..499		17/57 (30%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	500..560		28/62 (45%)
		Int_alpha	510..561	CDD:214549	22/50 (44%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	563..627		26/63 (41%)
		Int_alpha	574..633	CDD:214549	26/58 (45%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	631..691		19/76 (25%)
		Int_alpha	643..>678	CDD:214549	9/36 (25%)
		Integrin_alpha2	677..>951	CDD:462478	64/346 (18%)
		GFFKR motif	1150..1154		3/3 (100%)
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	22/51 (43%)
		Int_alpha	378..428	CDD:214549	26/57 (46%)
		Int_alpha	446..491	CDD:214549	12/44 (27%)
		Integrin_alpha2	480..1006	CDD:462478	101/561 (18%)