Protein Alignment CG9068 and DYN1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_012980.1
• Gene: DYN1 / 853928
• SGDID: S000001762
• Length: 4092
• Species: Saccharomyces cerevisiae
• Alignment Length: 1287
• Identity: 244/1287 - (18%)
• Similarity: 434/1287 - (33%)
• Gaps: 455/1287 - (35%)

  Fly   130 INFGTLTSDVDGCLMELLDRLYVPFFRNY-LEWNATVRNRFCSSMDRFLAFLSGMHHQISGMSVM 193
            :|.|.|.|.:...:..:..:|.....:.| :|.....|.:    :|........:|..|....::
Yeast   124 VNAGNLASIITHGVSSVFGQLIKSDTKTYSVETIDKTRRK----LDDISKQFQQLHTSIETPDLL 184

  Fly   194 -YVPFVI-----KELTAGPVDRYL----------VGSLEGIALYWTTQIRTLLADDTLTVPHDLV 242
             .||.:|     |..|:.....||          :..|:.||..|     .|:...||.:..|:.
Yeast   185 AMVPSIIKLAVSKGATSHDYANYLPSNDLESMRFLNILQSIANKW-----FLVLKQTLAIDRDIK 244

  Fly   243 --TVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLLHNAQSVHMPQMDGLIERARKELHKSLSN 305
              :..||.|||...||||:.:.:|....:.|..|.:|.||:..|  .:..|:...      |||:
Yeast   245 NGSFLDEVEFWSNFYEVLKSLIEQTQSQEFQVCLSVLTNAKRFH--NLTNLLNEG------SLSD 301

  Fly   306 -----IKYLHLLIE-PCSKIDAATSPADLTKLLPRIIHLIRFIWLNSEYYNTTRLIAALFRNLSN 364
                 .||...|.. |..::..|::..||.:|.|.:...::                 .||
Yeast   302 KFKLADKYNQFLSSIPIDEVRQASNLEDLQELFPVLASSLK-----------------KFR---- 345

  Fly   365 QIIRFCTKQTKVEEILSGKP--RFGIRICNVAIECCLTYRGIYDTISRDLAQKHTQMPWELDEGL 427
                           .||.|  ||.:               :.|.||:::
Yeast   346 ---------------YSGYPVQRFVV---------------LMDKISQEV--------------- 365

  Fly   428 IFNHIDAFVERLNDVIDICESMIVFGRLDENGSIPKPVFGGTCG--EELEKIAESVEVQFLDTLN 490
                :||.:..|:|:..:           |.||. ..::..:.|  ||.:.|.:.|.:...:.|.
Yeast   366 ----MDAILSNLSDLFQL-----------EYGSF-LGLYEKSAGMIEEWDDIVQDVNLLIREDLR 414

  Fly   491 KLQQNSQAYILNVHRADWYADVAGFRKNMQKLEETVQRLIFNVFQQVSNVEEMLEALQAMLFYSY 555
            |             ||.            |:|  .:|:|.|......:.::|:|...:.  |:|.
Yeast   415 K-------------RAP------------QEL--LIQKLTFTSASVKATLDEILSTRKR--FFSL 450

  Fly   556 RQRGTLR----KTYLKETSKLWRMFSKEMDATSRKLLEEQSRESWLSKHVSIALGYRINLERLTW 616
            .:  |::    .||.:|..:|:..|.:..|.:....|:.:..||..||::       ::||:
Yeast   451 AE--TIKSISPSTYHEEIQRLYHPFEQIHDISVNFRLKLEQAESEFSKNM-------LDLEK--- 503

  Fly   617 LRDRLKN-------SEWLPAVKESSPALAKFDALRHEFQKEIRLAYDDWVAKCCGFSGDLCQRL- 673
               :|:|       |:..|..|.|  .|.||..|.                       :||.|:
Yeast   504 ---KLQNTLASFMDSDHCPTEKLS--YLVKFKPLM-----------------------ELCPRIK 540

  Fly   674 ------DRYLVVRSKKFKGLLECNIDASVLELCEQAQHFERMGFAIPSTMKKLY-----ERYDTI 727
                  .:.|::..||....||..     |||..:..|.|.:....|.:.:..|     .|.|.|
Yeast   541 VKVLENQQILLLEIKKDIRQLETG-----LELLPKILHVEALNNIPPISARISYFLNVQSRIDNI 600

  Fly   728 ------------------RSLYNGIIKLALS---HNRILAVLSDRERKLFRPLIQACDRQLAPGV 771
                              ||:...|::|...   |:..|..|.:...|       |....|...:
Yeast   601 VQYLEALFGSNWNDTLEGRSISTSIVQLRKETNPHDVFLHWLGNFPEK-------ATANLLTTPI 658

  Fly   772 FKITYGSEFNEEFFEDGTEF-------IAEFQELVLIFKRANRGVARICE----------KICGT 819
            .|:...   ||:.:|....|       .:|.:.|..:..:....:.||..          .:...
Yeast   659 LKLIRN---NEDDYELKVNFDFALAAAYSELRSLTYMAFQVPSHIVRIARTYMYLYPRAINLVEL 720

  Fly   820 CLLHFAFSGSVDISVFQ--------------------------QQLSSRLSSS-----------G 847
            ....|:.|.|:..:.:.                          |:.||.:|.|           .
Yeast   721 IQTFFSLSKSLSYTFYTNIFLKRNVQTVWLLLQQILITPWESLQEESSEMSCSVHSLARLEKSID 785

  Fly   848 DILRSY---------YSHVVELLSAFSG-------------QFQSVDDEMSAEWIAYVND----M 886
            .||..|         ::.....|.:|.|             ..|::.:.:..:.:..|:|    .
Yeast   786 GILSDYQILKNSEPQFAKEFSGLKSFDGTADDLHEVEEIISNIQAIFENLFTKGLTNVSDHISTF 850

  Fly   887 DDMLASSLMTSARGSLNKLYEALHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDS 951
            ::::.|.::...|.:|.|::...|           |::....:|||..:|.:.|   |...::..
Yeast   851 NNLIISIILEKVRLNLKKMHFPKH-----------VLKLSFNEGRITSSPSLAA---MKRSLLKD 901

  Fly   952 IRSMLDQ-------------------FPRLGYKLKLPKKQQRQGFASVFRED-QECSELMRSIQA 996
            |.::|::                   |..|..|||               :| |.|.|.::::..
Yeast   902 IEALLNKVVLINFLHDPDHPLSTTLTFNSLVIKLK---------------DDIQNCIEQVQNLHC 951

  Fly   997 EIGIQREELAKYESEWNKNRVLWQTTEEEFRQRL-MSKSRTAGVFEGGIEHYSALADDVIFEDAI 1060
            :|.       .|..||.|...|||.|||.|.:.: .|..|..|:.:|.::..|..  |:|.....
Yeast   952 KIN-------SYVKEWQKMEFLWQITEEAFLEVVDNSTQRCFGILKGLLDSQSKF--DLIISRNN 1007

  Fly  1061 TNVYFILINQNA---LKSTMLDWIEKWQALNI-KMLLDHGSNLMGAVYRYMRRNERNVMKVPRTI 1121
            .:...:|..::|   ::|.|..||     |.: |.||        .:|      ||:..|:...:
Yeast  1008 FSKNLVLHTEDAQRHIRSKMDSWI-----LYVSKHLL--------TIY------ERDARKLHEDM 1053

  Fly  1122 ---RETVAAKQLFEKLLKDVPVKQSAFTPMLELFVLL------------HKYQVKLSEETFEQVM 1171
               ||.|          :|:.:.   ||.:..:.|::            ...|:||.......:.
Yeast  1054 NRDREAV----------EDMDIN---FTSLKNITVIIEAVNVNKRHLTERDIQIKLLGSVMRALT 1105

  Fly  1172 GLETAW-LHYLQVLEEADEMLDNEDSEAKLLLA---KHGEKFKLILKDFLED 1219
            .|:..: .|::.:     :.|||:.|..:..|:   :..:|.::::...||:
Yeast  1106 KLKVRFPSHFVYI-----DQLDNDFSSLRQSLSYVEQELQKHRVVIAKSLEE 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	127/627 (20%)
DYN1	NP_012980.1	DHC_N1	219..763	CDD:462457	136/722 (19%)
		DYN1	774..4083	CDD:227570	85/454 (19%)