Protein Alignment CG9068 and DYNC2H1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001073932.1
• Gene: DYNC2H1 / 79659
• HGNCID: 2962
• Length: 4314
• Species: Homo sapiens
• Alignment Length: 1251
• Identity: 246/1251 - (19%)
• Similarity: 452/1251 - (36%)
• Gaps: 362/1251 - (28%)

  Fly   110 LSYFRREPNEIFSVEGFHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVRNRFCSSMD 174
            |.:|:..| |:.:.|..||.|...::.......|.:.:.:::.|......||:   || |...:.
Human    76 LVFFKLRP-EVITDENLHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWS---RN-FDPKLQ 135

  Fly   175 RFLAFLSGMHHQISGMSVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLL---ADDTLT 236
            ..|:                      ||.||          .||.|..:....|.|   .|||
Human   136 NLLS----------------------ELEAG----------LGIVLRRSDTNLTKLKFKEDDT-- 166

  Fly   237 VPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLLHNAQSVHMPQMDGLIERAR--KEL 299
              ..::|..|||:||   .|.....|.|::.                         |||.  |||
Human   167 --RGILTPSDEFQFW---IEQAHRGNKQISK-------------------------ERANYFKEL 201

  Fly   300 HKSLS----NIKYLHLLIEPCSKIDAATSPADLTKLLPRIIHLIRFIWLNSE--YYNTTRLIAAL 358
            .::::    |:..|.||    ..:|...:..|          ::..:|..:|  :|..:|:: .|
Human   202 FETIAREFYNLDSLSLL----EVVDLVETTQD----------VVDDVWRQTEHDHYPESRML-HL 251

  Fly   359 FRNLSNQIIRFCTKQT-----------KVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISRDL 412
            ...:.....||..|:.           .|:|.|    :.||.||...:..|       :.::..:
Human   252 LDIIGGSFGRFVQKKLGTLNLWEDPYYLVKESL----KAGISICEQWVIVC-------NHLTGQV 305

  Fly   413 AQKHTQMPWELDEGLIFNHIDAFVERLNDVI---DICESMIVFGRLDENGSIPKPVFGGTCGEEL 474
            .|::...||: :|......:|...:||.:|:   .|.|..:.|....|...|        |   |
Human   306 WQRYVPHPWK-NEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKII--------C---L 358

  Fly   475 EKIAESVEVQFLDTLNKLQQNSQAYILNVHRADWYADVAGFRKNMQKLEETVQRLIFNVFQQVSN 539
            .::.|.     ...||.:|.|.....|      |.|.|:.:.|.:...|:.:...:.|...::.:
Human   359 TRVFEP-----FTGLNPVQYNPYTEPL------WKAAVSQYEKIIAPAEQKIAGKLKNYISEIQD 412

  Fly   540 VEEMLEALQAMLFYSYRQRGTLRKTYLKETSKLWRMFSKEMDATSRKLLEEQSRESWLSKHVSIA 604
            ..:.|  |||.|.|         |..:|..:     .|||:      :||   ||:.|::.|...
Human   413 SPQQL--LQAFLKY---------KELVKRPT-----ISKEL------MLE---RETLLARLVDSI 452

  Fly   605 LGYRINLER------------------------LTWLR-------DRLKNSEWLPAVKESSPALA 638
            ..:|::.|.                        :.|:|       |.:|.:|   |:....|...
Human   453 KDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAE---ALLSDLPGFR 514

  Fly   639 KFDALRHEFQKEIRL----AYDDWVAKC-CGFS---GDLC-QRLDRYLVVRSKKFKGLLECNIDA 694
            .|.....:...:::|    .:|||.... .|.|   ..|| :...|.:.:.|.  .|||:.:...
Human   515 CFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMELDSN--DGLLKVHYSD 577

  Fly   695 SVLELCEQAQHFERMGFAIPSTMKK---LYERY-------DTIRSLYNGIIKLALSHNRILAVLS 749
            .::.|..:.:....:||.||:.:::   :.:::       ..:...||.|.:..:...|.:.:.|
Human   578 RLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQS 642

  Fly   750 DRERKLFRPLIQACDRQLAPGVFKITYGSEFNEEFFEDGTEFIAEFQELVLIFKRANRGVAR--- 811
               ...|..:|:. .:..:.|..:||:.   |.:..|.   :|.:.|.........||.:.:
Human   643 ---ALAFEQIIKN-SKAGSGGKSQITWD---NPKELEG---YIQKLQNAAERLATENRKLRKWHT 697

  Fly   812 -ICEKICGTCLLHFAFSGSVDISVFQQQLSSRLSSSGDILRSYYSHVVELLSAFSGQFQSVDDEM 875
             .|||:  ..|:      ::|:...||:....|..    ||:      .|.:..:..||:.|  |
Human   698 TFCEKV--VVLM------NIDLLRQQQRWKDGLQE----LRT------GLATVEAQGFQASD--M 742

  Fly   876 SAEWIAYVNDMDDMLASSLMTSARGSLNKLYEALHCDADMA------SAPIIVVESDVKDGRIVF 934
            .| |..:.|                  ::||:||.....|.      :.|.|.::...|.||:.|
Human   743 HA-WKQHWN------------------HQLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQF 788

  Fly   935 TPDMDAIGDMINGIVDSIRSMLDQFPRLG-------YKLKLPKKQQRQGFASVFREDQECSELMR 992
            .|..:.|.......:.....:.:||..:|       :.:.:.:  ...||.::|   .:..:|.|
Human   789 RPPFEEIRAKYYREMKRFIGIPNQFKGVGEAGDESIFSIMIDR--NASGFLTIF---SKAEDLFR 848

  Fly   993 SIQAEIGIQREEL--------AKYES------EWNKNRVLWQTTEEEFRQRLMSKSRTAGVFEGG 1043
            .:.|.:...:|.:        |..|.      :|.||....:...:|. :||.|..:
Human   849 RLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEV-ERLPSAVK-------- 904

  Fly  1044 IEHYSALADDV--IFEDAITNVYFILINQNALKSTM---LDWIEKW--QALNIKMLLDHGSNLMG 1101
            ::..:...:.|  :.:|.|..::.:|:  .:||.::   |..|:.:  :|:.:..::......:|
Human   905 VDCLNINCNPVKTVIDDLIQKLFDLLV--LSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIG 967

  Fly  1102 -AVYRYMRRNERNVMKVP---------RTIRETVAAKQLFEKLLKDVPVKQSAFTPMLELFVLLH 1156
             |..:|.:..||....:|         |.:| |||...|  :.:.::..|...|..|:|...|:.
Human   968 DANLQYSKLQERKPEILPLFQEAEDKNRLLR-TVAGGGL--ETISNLKAKWDKFELMMESHQLMI 1029

  Fly  1157 KYQVKLSEET--------FEQVMGLETAWLHYLQVLEEADEMLDNE-----DSEAKLLLAKHGEK 1208
            |.|:::.:..        ::::...:..|    ..|:..|::::..     |..|||:      |
Human  1030 KDQIEVMKGNVKSRLQIYYQELEKFKARW----DQLKPGDDVIETGQHNTLDKSAKLI------K 1084

  Fly  1209 FKLILKDFLEDFYSKL 1224
            .|.|..|.||....||
Human  1085 EKKIEFDDLEVTRKKL 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	128/646 (20%)
DYNC2H1	NP_001073932.1	Stem. /evidence=ECO:0000250	1..1650		246/1251 (20%)
		DHC_N1	<234..674	CDD:462457	100/514 (19%)
		DHC_N2	1120..1518	CDD:462462
		DYN1	<1361..4023	CDD:227570
		AAA_6	1651..1986	CDD:463697
		AAA 1. /evidence=ECO:0000250	1651..1875
		AAA 2. /evidence=ECO:0000250	1938..2161
		AAA 3. /evidence=ECO:0000250	2251..2505
		AAA 4. /evidence=ECO:0000250	2617..2863
		Stalk. /evidence=ECO:0000250	2881..3169
		AAA 6. /evidence=ECO:0000250	3697..3912
		Dynein_C	4018..4311	CDD:465677