Protein Alignment CG9068 and Dnhd1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001357732.1
• Gene: Dnhd1 / 77505
• MGIID: 1924755
• Length: 4749
• Species: Mus musculus
• Alignment Length: 1430
• Identity: 272/1430 - (19%)
• Similarity: 464/1430 - (32%)
• Gaps: 505/1430 - (35%)

  Fly    18 TDDEERSVEP--RQEEIRPETPKPSYSDEELNQLVGYIQRMSVLSCLDHRDWQEGTLDIIRGWLL 80
            :|.|:...||  |:.::..|.|:.....::.::..  :.|..|.|.|: |||.:          .
Mouse   277 SDTEQAEGEPAGRKLQVASEAPEEKALKKKSSRTP--VLRSQVKSLLE-RDWTQ----------K 328

  Fly    81 EVHEPLLTIYYDRD----ALAACLGMPSMCVSDLSYFRREPNEIFS---------VEGFHDEINF 132
            ::|...|.:..||.    .|.|   :|...|:...|       |||         ||| .:.:..
Mouse   329 KIHFLYLNVVSDRHFNPYKLVA---VPPDKVNPEHY-------IFSPFGILHIHPVEG-SEAMTL 382

  Fly   133 GTLTSDVDGCLMELLDRLYVPFFRNYLE------WNATVRNRFCSSMDRFLA--FLSGMHHQISG 189
            ||...|.  .|...|.|  :|||:|.|.      |...||......:..||.  .||.:.|..:|
Mouse   383 GTWHRDC--ALWRELQR--IPFFKNCLLRKALTCWKKNVRLCGLHRIQTFLKTHLLSAIPHFGAG 443

  Fly   190 M-----------SVMYVPFVIKELTAGPVDRY-LVGSLEGIA-------------LYWTTQIRTL 229
            |           ||.::|   ||    |...| ||...:.||             |...|.|..|
Mouse   444 MLHINRLLQEFRSVSWLP---KE----PDRSYELVDLQKAIAKENHKALRVLCHFLNLCTSILQL 501

  Fly   230 LADDTL---------------------------TVPHDLVTVRDEFEFWEYR---------YEVL 258
            :.:||.                           |:...|.....:.|.|..:         |.:.
Mouse   502 IHEDTYQMQQGLQERVQNWNRIRKGQGSIYLQRTLCRHLEKKLKQAETWLLKLGKFARLIDYMIC 566

  Fly   259 QG----INDQLA-------HSDVQKVLLLLH-----NAQSVHMPQMDGLIERARKELHKSLSNIK 307
            |.    :.|:::       .:..|...||..     |.|...||:::.:|:    .|.|||.:||
Mouse   567 QNLVSILEDEISSFIANTLQAPRQNPFLLSQLVFDDNGQLSPMPRVESIIQ----GLIKSLQSIK 627

  Fly   308 YLHLLIEPCSKIDAATSPADLTKLLPRIIHLIRFIWLNSEYYNTTRLIAALFRNLSNQIIR-FCT 371
            ...|.:  ....|..|| .||.           :...|.:..:....:...|...::..:| ||
Mouse   628 TSALKV--LQSTDLRTS-RDLL-----------YSEDNKDQDSNAEFLMPKFHGKASDAVRLFC- 677

  Fly   372 KQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISRDLAQKHTQMPWELDEGLIFNHIDAFV 436
                       .|..|.                             ..||:       :|
Mouse   678 -----------GPNVGY-----------------------------VWPWK-------SH----- 690

  Fly   437 ERLNDVIDICESMIVFGRLDENGSIPKPVFGGTCGEELEK---IAESVEVQFLDTLNKLQQNSQA 498
             .:.||:::....:       .|....|.:... .|:|:|   |.:::.|| ...|..::|..|.
Mouse   691 -AITDVLEVRGHKL-------RGQFLHPNYDHV-QEDLDKNAGIQQALAVQ-QSLLEDMRQEVQE 745

  Fly   499 YILNVHRADWYADVAGFRK--NMQKLEE----TVQRLIFNVFQ------QVSNVEEMLEALQAML 551
            : .|.|:  |...:..|.|  :.||||:    .:...:..|.|      :|||:...|.....:|
Mouse   746 F-CNKHK--WVEGIYEFLKAWSSQKLEDLRGSPINNYVNLVIQLKKWQERVSNMSVELLTKGKLL 807

  Fly   552 FYS----YRQRGT----LRK------------------TYLKETSKLWRMFSKEMDA---TSRKL 587
            |.|    ..:.|:    :||                  |.|.|..::::..|.::.|   .|:||
Mouse   808 FLSGHDVQEELGSKLNNMRKNILEQAQNECWSRNQQLMTELTEFLRVFQTISSDIHAIAQCSQKL 872

  Fly   588 LEEQSRESWLSKHVSIALGYRINLERLTWLRDRLKNSEWLPAVKESSPALAKFDALRHEFQKEIR 652
            .|...:...|.:.|          |.:..|.|.::|...|...:..:..:|..| |...||.|..
Mouse   873 SEANEQYCQLEERV----------EYVRSLHDLIRNHCALFIAENETLDIALLD-LWEAFQFERS 926

  Fly   653 LAYDDWVAKCCGFSGDLCQRLDRYLVVRSKKFKGLLECNIDASVLELCEQAQHFERMGFAIPSTM 717
            ...:..::|    ...:..||.:.:.....:.:|||...:....::..::.:..|:...|:....
Mouse   927 QVSEFLLSK----QHAIVPRLQQLMAAALAELEGLLAKALSGPFMDPSQEQRSTEQQLGALEHQF 987

  Fly   718 KKLYERYDTIRSLY---NGIIK---LALSHNRILAVLSDRERKLFRPLIQACDRQLAPGVFKITY 776
            ..:...::.:.:.|   .|..|   ...|.||.: ||..|..:|:|.:.:..      |.:|...
Mouse   988 LNILNNFNALCNAYCTFTGYKKPMSPPASGNRPI-VLQQRIWRLYRIISENL------GEWKCVA 1045

  Fly   777 GSEFNEEFFEDGTEFIAEFQELVLIFKRANRGVARICEKICGTCLLHFAFSGSVDISVFQQQLSS 841
            .|:||.....:.|:                   |.:.|.:                     :||:
Mouse  1046 FSKFNLSMAREKTD-------------------AWLTEAV---------------------RLST 1070

  Fly   842 RLSSSGDIL----------RSYYSHVVELLSAFSGQFQSVDDEMSAEWIAYVNDMDDMLASSLMT 896
            .|.....:|          |:|...:::|     |..|                :.|:...||:.
Mouse  1071 ALGLQSPVLQRCMRMLEEFRAYLPLLIKL-----GNLQ----------------LQDLNTQSLLR 1114

  Fly   897 S-ARGSLNKLYEALHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLDQFP 960
            : ..|||..|                               |:..:|.|:|            :|
Mouse  1115 ALGLGSLRSL-------------------------------DLLTLGQMLN------------YP 1136

  Fly   961 RLGYKLKLPKKQQRQGFASVFREDQECSELMRSIQAEIGIQREELAKYESEWN------KNRVLW 1019
            .|.:..::.:         |::.|:|      .|.|:     |.|.:.:..|.      .|.:|.
Mouse  1137 LLEFAERINQ---------VWQYDKE------RIHAQ-----EILQQMQQYWEGRQLRLLNFILH 1181

  Fly  1020 -----QTTEEEFRQRLMSK-----SRTAGVFEGGIEHYSALADDVIFEDAITNVYFILINQNA-- 1072
                 .|:|...|..|.|.     .:.:|.|.  :..||:|.|.:  ::::..::.||..|.:
Mouse  1182 VPYKPPTSERSKRPALRSPQWELVGKDSGTFL--LSDYSSLQDAI--QNSLQALFKILAIQKSGQ 1242

  Fly  1073 LKSTMLDWI-----------------EKWQALN---IKMLLDHGSNLMGAVYRYMRRNERNVMKV 1117
            |....|:|:                 :||..||   .:|.::..:..:.|.::.|....|.:|::
Mouse  1243 LHKIALEWVAIMYGLGALLEVWVAFQQKWIFLNKVLHEMKIEFPAPELNARFKAMDDQYRTLMRI 1307

  Fly  1118 ------------PRTIRETVAAKQLFEKLLKDVPVKQSAFTPMLE------------LFVLLHKY 1158
                        |.|.|......|..:::||....:..|....||            ||.|....
Mouse  1308 SVADPMVLSLILPNTKRSPYFQGQHLQQMLKAGSGELEAIIMALEDVLYGVCANFPRLFFLSDSE 1372

  Fly  1159 QVKLSE---ETFEQVMGLETAWLHYLQVLEEA---------DEMLDNEDSEAKLLLAKHGEKFKL 1211
            .|.|..   :|.|..:..:..:.|...|...:         |.....|.:|...:||..||:.||
Mouse  1373 LVALLAAPLDTREAQLWAQRCFPHIKAVNFRSKSTKKKINQDSSSSTESAETIAVLAAGGEEVKL 1437

  Fly  1212  1211
            Mouse  1438  1437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	126/687 (18%)
Dnhd1	NP_001357732.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..308		7/30 (23%)
		DHC_N2	1021..1469	CDD:462462	98/552 (18%)
		AAA_6	1652..2005	CDD:463697
		Dynein_AAA_lid	2187..2349	CDD:465532
		AAA_7	2366..2533	CDD:463698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2690..2785
		AAA_8	2869..>3020	CDD:463701
		MT	3151..3468	CDD:463699
		AAA_9	3547..3801	CDD:463702
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3568..3667
		Dynein_heavy	4083..4222	CDD:460782
		Dynein_C	<4519..4741	CDD:465677