Protein Alignment CG9068 and DNAH7

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_061720.2
• Gene: DNAH7 / 56171
• HGNCID: 18661
• Length: 4024
• Species: Homo sapiens
• Alignment Length: 1344
• Identity: 231/1344 - (17%)
• Similarity: 458/1344 - (34%)
• Gaps: 459/1344 - (34%)

  Fly    10 EHL---TDSDLT-DDEER-----SVEPRQEEIRPETPKPSYSDEELNQLVGYIQRMSVLSCLDHR 65
            :||   |||.:| .||.|     ||.....:...:.|:....|::.::|..:...|.:|.    :
Human   194 QHLKVFTDSIVTLSDEMREDYLLSVRKSIVDFVLKDPREKGDDKKTDELPAHRAEMEILP----K 254

  Fly    66 DWQEGTLDIIRGWLLEVHEPLLTIYYDRDALAACLGMPSMCVSDLSYFRREPNEIFSVEGFH--- 127
            .|::..              |....|.||.|.| :....:.|.||.:...:...:..::.||
Human   255 PWRKSF--------------LAASSYIRDHLNA-MNPTMLAVLDLWHTNFKKLRLVDIKEFHNCQ 304

  Fly   128 DEINFGTLTSDVDGCLMELLD-------RLYVPFFRN-YLEWNATVRNRFCSSMDRFLAFLSG-- 182
            |.:..    |.....:|..:|       :::.|..:| |.:.|...:.....|..:..:|.:.
Human   305 DALEL----SSFQNIIMRHMDSAKETLLKMWFPEVQNIYYQGNKKKQLPTGDSSAKLESFFNCAA 365

  Fly   183 --MHHQISGMSVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLLADDTLTVPHDLVTVR 245
              |..|:..::::.:. ...:|.|.|.|........|..:      |.:|.:||:....:|....
Human   366 ALMTLQLQDLTLVSMQ-DFTDLIAQPPDSVRAFEHPGFIM------RLILDNDTIKFEPELSDYI 423

  Fly   246 DEF----------------------EFWEYRYE-------VLQGINDQLAHSD-VQKVLLLLHNA 280
            |.|                      ..||.:.:       :|..|.|  ||.: :::|::....|
Human   424 DIFLNVYDVMIKAVSFVPRVETKLYSKWESKSKPTTLKPIILNEIVD--AHKEKIKEVIMKESVA 486

  Fly   281 QSVHM---PQMDGLIER-ARKELHKSLS-NIKYLHLLIEPCSKIDAATSPADLTKLLPRI----- 335
            .:.|:   .:.|.||.| |.:::...|: |..|..::.|.|.          ..||:..|
Human   487 PTEHLRLYDKYDFLITRKAERDVDNFLAENHSYEKIIDEICK----------YQKLIEEIQYTSI 541

  Fly   336 ---------IH---LIRFIWLNSEYYNTTRLIAALFRNLSNQIIRFCTKQTKV-EEILSGKPRFG 387
                     :|   |||.:...::.. ..:|:|.:||:......|.|.:..:: |:.||..|...
Human   542 KTIRLGMFEMHCEELIRALVKRADII-CGKLLAKMFRDHQEVNTRLCDEFERIAEKALSTPPNTA 605

  Fly   388 -----------IRICNVAIEC---------CLTYRGIYDTIS-RDLAQKHTQMPWELDEGLIFN- 430
                       :.:.:: ||.         ||.:...|...| .|:...::...|....|.||.
Human   606 ELMEMKAYIQKVEVTDM-IELEQRLVDSKNCLAFLIEYVNFSPADMRLNNSVFQWYGRMGEIFEE 669

  Fly   431 ------------------HIDAFVERLNDVIDICESMIVFGRLDE-----------NGSI----- 461
                              ..:.|||.|.......|....||.|.:           ||.:
Human   670 HRKIIKEKIEQYQEGLKLRCERFVEELESYAKQSEEFYSFGDLQDVQRYLKKAQILNGKLDLAAD 734

  Fly   462 -------PKPVFG--GTCGEELEKIAESVE--VQFLDTLNKLQQNSQAYI------LNVHRADWY 509
                   .:..||  .:...:.:||.:.:.  ::..:|..:...|.:|:.      :|..:.:
Human   735 KIEQFNAEEEAFGWLPSVYPQRKKIQDGLNPYLRLYETAVEFSSNYRAWTEGPYHKVNPDQVE-- 797

  Fly   510 ADVAGFRKNMQKLEETVQ------RLIFNVFQQVSNVEEMLEALQAMLFYSYRQRGTLRKTYLKE 568
            ||:..:.:.:.|||:|..      .:...|..:|.:.::.:..:|.:.....|.|.
Human   798 ADIGNYWRGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPLIQVICNPGLRPRH--------- 853

  Fly   569 TSKLWRMFSKEM--------DATSRKLLEEQSRESWLSKH--VSIALGYRINLERLTWLRDRLKN 623
                |...|..:        |:|....| :.:.|.::.:.  :|.|.....:||
Human   854 ----WEAMSAIVGYPLQPSDDSTVSSFL-DMNLEPYIDRFEGISEAASKEYSLE----------- 902

  Fly   624 SEWLPAVKESSPALAKFDALR---HEFQK----------EIRLAYDDWVAKCCGFSGD------- 668
                   |.....:.::||:.   |.:::          ||::..||.:.|.....|.
Human   903 -------KAMEKMITEWDAVEFVIHSYRETGTFILASVDEIQMLLDDHIIKTQTMRGSPFIKPYE 960

  Fly   669 ------------LCQRLDRYLVVRSKKFKGLLECNIDASVLELCEQAQHFERMGFAIPSTMKKLY 721
                        |.:.||.:|.|::...                    :.|.: |:.|..|.::.
Human   961 KQMREWEGKLLLLQEILDEWLKVQATWL--------------------YLEPI-FSSPDIMSQMP 1004

  Fly   722 E---RYDTIRSLYNGIIKLALSHNRILAVLS-DR--ER-----KLFRPLIQACDRQLA------P 769
            |   |:..:...:..|::..:....:|.|:: ||  ||     :|...:::..:..|.      |
Human  1005 EEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTIDRMLERLKKSNELLELILKGLNEYLEKKRLFFP 1069

  Fly   770 GVFKITYGSEFNEEFFEDGTEFIAEFQELVLI---FKRANRGVARICEKICGTCLLHFAFSGSVD 831
            ..|.::     |:|..    |.::|.::...:   .|:...|:|::            .|:.::|
Human  1070 RFFFLS-----NDELL----EILSETKDPTRVQPHLKKCFEGIAKV------------EFTETLD 1113

  Fly   832 ISVFQQQLSSRLSSSGDILRSYYSHVVELLSAFS--GQFQSVDDEMSAEWIAYVNDMDDMLASSL 894
            |:..:       ||.|:::     .::|::|...  ||.:        :|:.   :::.::.:|:
Human  1114 ITHMK-------SSEGEVV-----ELIEIISTAKARGQVE--------KWLV---ELERVMINSI 1155

  Fly   895 --MTSARGSLNKLYEALHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLD 957
              :|.........||.::...|.....::.|      .:|.:|.::.....|  ||     ..|:
Human  1156 HKVTGDATFAYTKYERINWVRDWPGQTVLCV------SQIFWTKEVQTAIPM--GI-----KALE 1207

  Fly   958 QFPRLGYKLKLPKKQQRQGFASVFREDQECSELMRSIQAEIGIQREELAKYESEWNKNRVLWQTT 1022
            |:      ||...:|              ..:::..::.::.:|             |||
Human  1208 QY------LKTCNRQ--------------IDDIVTLVRGKLSMQ-------------NRV----- 1234

  Fly  1023 EEEFRQRLMSKSRTAGVFEGGIEHYSALADDVIFEDAITNVYFILINQNALKSTMLDWIEK---- 1083
                         |.|         :.:..||...|.:::    |:.:|....:..:|:.:
Human  1235 -------------TLG---------ALVVLDVHARDVLSS----LVKKNISDDSDFEWLSQLRYY 1273

  Fly  1084 WQA--LNIKML---LDHGSNLMGAVYRYMRRNERNVMKVPRTIR 1122
            ||.  |..||:   |.:|       |.|:..:.|.|: .|.|.|
Human  1274 WQENHLETKMINAGLRYG-------YEYLGNSPRLVI-TPLTDR 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	128/762 (17%)
DNAH7	NP_061720.2	Stem. /evidence=ECO:0000250	1..1289		222/1314 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..121
		DHC_N2	757..1162	CDD:462462	79/503 (16%)
		DYN1	959..3663	CDD:227570	82/501 (16%)
		AAA_6	1290..1616	CDD:463697	8/28 (29%)
		AAA 1. /evidence=ECO:0000250	1290..1511		8/28 (29%)
		AAA 2. /evidence=ECO:0000250	1571..1802
		AAA 3. /evidence=ECO:0000250	1938..2189
		AAA 4. /evidence=ECO:0000250	2302..2555
		AAA_8	2311..2573	CDD:463701
		Stalk. /evidence=ECO:0000250	2572..2873
		AAA 5. /evidence=ECO:0000250	2954..3184
		AAA_9	2961..3182	CDD:463702
		AAA 6. /evidence=ECO:0000250	3397..3620
		Dynein_C	3720..4020	CDD:465677