Protein Alignment CG9068 and DNAH3

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: XP_016878921.1
• Gene: DNAH3 / 55567
• HGNCID: 2949
• Length: 4130
• Species: Homo sapiens
• Alignment Length: 1513
• Identity: 256/1513 - (16%)
• Similarity: 510/1513 - (33%)
• Gaps: 530/1513 - (35%)

  Fly    72 LDIIRGWL-------------LEVHEPLLTIYYDRDALAACLGMPSMCVSDLS-YFRREPNEIFS 122
            ::::|.|:             |::.:.|         |...:|.|....:|:: .|.|..| |.|
Human  2171 IELLRQWIDHGYWFDKKDTTRLDIVDML---------LVTAMGPPGGGRNDITGRFTRHLN-IIS 2225

  Fly   123 VEGFHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVRNRFCSSMDRFLAFLSGMHHQI 187
            :..|.|:|.....:|.||....:..|.:::.:.:..::...|:   :..:::.||...|..|
Human  2226 INAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTI---YRDAVENFLPTPSKSH--- 2284

  Fly   188 SGMSVMYVPFVIKELTAGPVDRYLVGSL----------EGIALYWTTQIRTLLADDTLTVPHDLV 242
                  || |.:::.:     |.:.|.|          |.....|..::..:..|       .|:
Human  2285 ------YV-FNLRDFS-----RVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYD-------RLI 2330

  Fly   243 TVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLL--------HNAQSVHM-----PQMDGLIER 294
            ...|...|    :.:::..........::|||:.|        .|.:|:..     |:.|
Human  2331 DKEDRQVF----FNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESD----- 2386

  Fly   295 ARKELHKSLSNIKYLHLLIEPCSKIDAATSPADLTKLLPRIIHLIRFIWLNSEYYNTTR--LIAA 357
              ::::..::::|.|.:::|                      |.:      .|:.|.::  :...
Human  2387 --QKIYDEITDLKQLTVVME----------------------HYL------EEFNNISKAPMSLV 2421

  Fly   358 LFRNLSNQIIRFC--TKQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISRDLAQKHTQMP 420
            :||.....|.|.|  .||.|...:|.|....|    ..:.....|:...|:....::.:.:....
Human  2422 MFRFAIEHISRICRVLKQDKGHLLLVGIGGSG----RQSAAKLSTFMNAYELYQIEITKNYAGND 2482

  Fly   421 WELD------------EGLIF----NHI--DAFVERLNDVIDICESMIVFGRLDENGSIPKPV-- 465
            |..|            :..:|    |.|  ::|||.:|.:::..:...:| ..||...|.:.:
Human  2483 WREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIF-PADEKADIVEKMQT 2546

  Fly   466 FGGTCGEELEKIAESVEVQFLDTLNK-------LQQNSQAY---------ILNVHRADWY----- 509
            ...|.||::|....|:...|::.:.|       :.....|:         ::|....||:
Human  2547 AARTQGEKVEVTPLSMYNFFIERVRKNLHIVLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPT 2611

  Fly   510 ---------------------ADVAGFRKNMQKLEETVQRLIFNVFQQV--------SNVEEMLE 545
                                 .:|....|..|   |:|::|..:.:.::        ::..|::.
Human  2612 DALELVANKFLEDVELDDNIRVEVVSMCKYFQ---ESVKKLSLDYYNKLRRHNYVTPTSYLELIL 2673

  Fly   546 ALQAMLFYSYRQRGTLRKTYL-------------------------------KETSKLW-RMFSK 578
            ..:.:|....::...:|..||                               :||:|:. ::.::
Human  2674 TFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAE 2738

  Fly   579 EMDATSRKLLEEQSRESWLSKHVSIALGYRINLERLTWLRDRLKN------SEWLPAVKESSPAL 637
            ..:|..:||| .|:.|...:...:||.|              :||      :|.:||::   .||
Human  2739 TREADGKKLL-VQADEKEANVAAAIAQG--------------IKNECEGDLAEAMPALE---AAL 2785

  Fly   638 AKFDALR-------HEFQK---EIRLAYDDWVAKCCGFSGDLCQR----------LDRYLVVRSK 682
            |..|.|.       ...|.   .::|..:    ..|...|...:|          ::.|..| ||
Human  2786 AALDTLNPADISLVKSMQNPPGPVKLVME----SICIMKGMKPERKPDPSGSGKMIEDYWGV-SK 2845

  Fly   683 KFKGLLECNIDASVLELCEQAQHFERMGFAIPSTMKKLYERY-----------DTIRSLYNGIIK 736
            |..|         .|:..|..:.:::.... |.|||::.||:           ..:.|...|:.|
Human  2846 KILG---------DLKFLESLKTYDKDNIP-PLTMKRIRERFINHPEFQPAVIKNVSSACEGLCK 2900

  Fly   737 LALS---HNRILAVLSDRERKLFRPLIQACDRQLAPGVFKITYG-----------SEFNEEFFED 787
            ...:   ::|:..|::.:..:|     :..:.:||..:.|:...           ...|::|.|.
Human  2901 WVRAMEVYDRVAKVVAPKRERL-----REAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEM 2960

  Fly   788 GTEFIAEFQELVLIFKRANRGVARIC-EKICGTCLLHFAFSGSVD-ISVFQQQLSSRLSS-SGDI 849
            .|:            |:.......|| :|:.....|.....|..| .:...:||..|.:: :||:
Human  2961 NTK------------KKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDV 3013

  Fly   850 LRSYYSHVVELLSAFSGQFQSVDDEMSAEWIAYVND-----MDDMLAS----------------- 892
            |.|  |..|..|.||:..::.   :...:|:|...|     ..|...|
Human  3014 LLS--SGTVAYLGAFTVDYRV---QCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGL 3073

  Fly   893 -------------------SLMTSARGSLNKLYEALHCDADMASAPIIVVESD------VKDGRI 932
                               :||....|..||..:    :.:.|:...::..||      :::...
Human  3074 PVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIK----NMEKANKLAVIKFSDSNYMRMLENALQ 3134

  Fly   933 VFTPDM-DAIGDMINGIVDSI------RSMLDQFPRLG---------YKL----------KLPK- 970
            :.||.: :.||:.::..::.|      :....::.|||         :||          .||:
Human  3135 LGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEV 3199

  Fly   971 ----------------KQQRQGFASVFREDQECSELMRSIQAEIGIQREELAKYESE------WN 1013
                            :.|..|..:. :|..|..|....:..|....::.|.:.|.:      .:
Human  3200 AVKVCLLNFMITPLGLQDQLLGIVAA-KEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMS 3263

  Fly  1014 KNRVLWQTT-------EEEFRQRLMSKSRTAGVFEGGIEH------------------YSALAD- 1052
            |..:|...|       .:...:.:..|.:.|.:.|..|:.                  .|.||:
Human  3264 KGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANI 3328

  Fly  1053 DVIFEDAITNVYFILINQNAL----KSTMLDWIEKWQALNIKMLLDHGS-NLMGAVYRYMRRNER 1112
            :.:::.::|  :||.:..::|    ||..|:       |.||.::||.: ::...|.|.:...::
Human  3329 EPMYQYSLT--WFINLYMHSLTHSTKSEELN-------LRIKYIIDHFTLSIYNNVCRSLFEKDK 3384

  Fly  1113 ---------NVMKVPRTIRETV------------------AAKQLFEKLLKDVPVKQSAFTPMLE 1150
                     .:||..:.|.|.|                  |.:.|.||...:: |:.||...
Human  3385 LLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEI-VRASALPK--- 3445

  Fly  1151 LFVLLHKYQVKLSEETFEQVMGLETAWLH---------YLQVLEEADEMLDNEDSEAKLLLAKHG 1206
                ||.....|.:...|..:..::||.|         :.|.||           :..:|.....
Human  3446 ----LHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLE-----------KMVILRCLRP 3495

  Fly  1207 EKFKLILKDFLEDFYSKL 1224
            :|....:::|:.:...||
Human  3496 DKMVPAVREFIAEHMGKL 3513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	121/751 (16%)
DNAH3	XP_016878921.1	DHC_N2	873..1276	CDD:462462
		DYN1	1076..3757	CDD:227570	256/1513 (17%)
		AAA_6	1405..1731	CDD:463697
		AAA_8	2418..2678	CDD:463701	44/267 (16%)
		AAA_9	3066..3287	CDD:463702	31/225 (14%)
		Dynein_C	3825..4126	CDD:465677