Protein Alignment CG9068 and Dnah3

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001357735.1
• Gene: Dnah3 / 381917
• MGIID: 2683040
• Length: 4072
• Species: Mus musculus
• Alignment Length: 1456
• Identity: 260/1456 - (17%)
• Similarity: 502/1456 - (34%)
• Gaps: 478/1456 - (32%)

  Fly    72 LDIIRGWL-------------LEVHEPLLTIYYDRDALAACLGMPSMCVSDLS-YFRREPNEIFS 122
            ::::|.|:             |::.:.|         |...:|.|....:|:: .|.|..| |.|
Mouse  2113 IELLRQWIDHGYWFDKKDTNRLDIVDVL---------LVTAMGPPGGGRNDITGRFTRHLN-IIS 2167

  Fly   123 VEGFHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVRNRFCSSMDRFLAFLSGMHHQI 187
            :..|.|||.....:|..|....:..|.:::.:.:..::...|:   :.::::.||...|..|
Mouse  2168 INAFEDEILTKIFSSIADWHFGKGFDVMFLRYGKMLVQATQTI---YRAAVENFLPTPSKSH--- 2226

  Fly   188 SGMSVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLLADDTLTVPHDLVTVRDEF-EFW 251
                  || |.:::.:     |.:.|                    .|..||..:...::| ..|
Mouse  2227 ------YV-FNLRDFS-----RVIQG--------------------VLLCPHTHLQDLEKFIRLW 2259

  Fly   252 EYRYEVLQGINDQLAHSDVQKVLLLLHNAQSVHMPQMDGLIERARKELHKSLSNIKYLHLLIEPC 316
              .:||.:...|:|..:|.::...              .|::.......|.......:||  .|.
Mouse  2260 --IHEVYRVFYDRLIDNDDRQTFF--------------NLVKETTSNCFKQTMEKVLIHL--SPT 2306

  Fly   317 SKI--DAATS--------PADLTKLLPRIIHLIRFIWLNSEYY-------NTTRLIAALFRNLSN 364
            .||  |...|        |....|:...||.| |.:.:..|||       :...:...:|:....
Mouse  2307 GKITDDNIRSLFFGDYLKPESDQKIYDEIIDL-RGLTVVMEYYLDEFNSVSKAPMSLVMFKFAIE 2370

  Fly   365 QIIRFC--TKQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISRDLAQKHTQMPWELD--- 424
            .|.|.|  .||.|...:|.|....|    ..:.....|:...|:....::.:.:|...|..|
Mouse  2371 HISRICRVLKQKKGHLLLVGIGGSG----RQSATKLSTFMNSYELYQIEITKNYTNSDWREDLKK 2431

  Fly   425 ---------EGLIF----NHI--DAFVERLNDVIDICESMIVFGRLDENGSIPKPV--FGGTCGE 472
                     :..:|    |.|  ::|||.:|.:::..:...:| ..||...:.:.:  ...|.||
Mouse  2432 IMLQSGVATKSTVFLFSDNQIKHESFVEDINMLLNTGDVPNIF-PADEKADLVEKMQTAARTEGE 2495

  Fly   473 ELEKIAESVEVQFLDTLNK-------LQQNSQAY---------ILNVHRADWY------------ 509
            ::|....|:...|::.:.|       :.....|:         ::|....||:
Mouse  2496 KVEATPLSMYNFFIERVRKNLHIVLAMSPIGDAFRTRLRMFPSLINCCTIDWFQSWPTDALELVA 2560

  Fly   510 --------------ADVAGFRKNMQKLEETVQRLIFNVFQQV--------SNVEEMLEALQAMLF 552
                          |:|....|..|   |:|::|..:.:..:        ::..|::...:.:|.
Mouse  2561 NKFLEDVELDDNIRAEVVSMCKYFQ---ESVKKLSVDYYNTLLRHNYVTPTSYLELILTFKTLLN 2622

  Fly   553 YSYRQRGTLRKTYLKETSKLWRMFSK------EMDATSRKLLEEQSRESWLSKHVSIALGYR-IN 610
            ...::..|:|..||....||....|:      |:.|...:|:  |:.|......|.|.|..: .:
Mouse  2623 SKRQEVDTIRNRYLAGLQKLEFASSQVAVMQVELTALQPQLI--QTSEDTAMMMVKIELETKEAD 2685

  Fly   611 LERLTWLRDR------------LKN------SEWLPAVKESSPALAKFDALR-------HEFQK- 649
            .::|....|.            :||      :|.:||::   .|||..|.|.       ...|.
Mouse  2686 AKKLLVQADEKEANAAAAISQAIKNECEGDLAEAMPALE---AALAALDTLNPSDITLVKSMQNP 2747

  Fly   650 --EIRLAYDDWVAKCCGFSGDLCQR----------LDRYLVVRSKKFKGLLECNIDASVLELCEQ 702
              .::|..:    ..|...|...:|          ::.|..| |:|..|         .|:..|.
Mouse  2748 PGPVKLVME----SICVMKGLKPERKPDPSGSGKMIEDYWGV-SRKILG---------DLKFLES 2798

  Fly   703 AQHFERMGFAIPST-MKKLYERY-----------DTIRSLYNGIIKLALS---HNRILAVLSDRE 752
            .:.:::..  |||. ||::.||:           ..:.|...|:.|...:   ::|:..|::.:.
Mouse  2799 LKTYDKDN--IPSVIMKRIRERFIDHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKR 2861

  Fly   753 RKLFRPLIQACDRQLAPGVFKITYGSEFNE-----EFFEDGTEFIAEFQELVLIFKRANRGVARI 812
            .:|          :.|.|..:|.. .:.|:     :..||..:.:.:..||:...|.:......|
Mouse  2862 ERL----------REAEGKLEIQM-QKLNQKRAELKLVEDRLQDLNDEFELMNRKKNSLEKNIEI 2915

  Fly   813 C-EKICGTCLLHFAFSGSVD-ISVFQQQLSSRLSS-SGDILRSYYSHVVELLSAFSGQFQSVDDE 874
            | :|:.....|.....|..| .:...:||..|..: :||:|.:  |..|..|.||:..:::   :
Mouse  2916 CSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYDNLTGDVLLA--SGTVAYLGAFTVDYRA---Q 2975

  Fly   875 MSAEWIAYVND------MDDMLASS-----------------------------------LMTSA 898
            ...||:....|      :|..|:::                                   ||...
Mouse  2976 CQNEWLVSCKDKVIPGSVDFSLSNTLGDPIKIRAWQIAGLPVDSFSVDNGIIVSNSRRWPLMIDP 3040

  Fly   899 RGSLNKLYEALHCDADMASAPIIVVESDVK-----DGRIVF-TPD-MDAIGDMINGIVDSI---- 952
            :|..||..:    :.:..:...::..||..     :..:.| ||. ::.:|:.::..::.|
Mouse  3041 QGQANKWVK----NMEKTNKLSVIKFSDTNYVRTLENALQFGTPVLLENVGEELDAFIEPILLKA 3101

  Fly   953 --RSMLDQFPRLGYKLKLPKKQQRQGFASVFREDQECSE------LMRSIQAEIGIQREELA--- 1006
              :....::.|||..:....::.:....:..|......|      |:..:...:|:|.:.|.
Mouse  3102 TFKQQGVEYMRLGENIIEYSREFKFYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVA 3166

  Fly  1007 ---KYESEWNKNRVLWQTT-------------------------EEEFRQRLMSKSRT------- 1036
               |.|.|..||:::.::.                         |:|...:::|.|:.
Mouse  3167 AKEKPELEEKKNKLILESAQNKKQLKEIEDKILEVLSLCEGNILEDETAIKILSSSKVLSEEISE 3231

  Fly  1037 ----AGVFEGGIE-----------HYSA----LAD----DVIFEDAIT---NVYF-ILINQNALK 1074
                |.|.|..|:           |.:|    ::|    :.:::.::|   |:|. .|.|.|  |
Mouse  3232 KQEIASVTETQIDETRMGYKPVAVHSAAIFFCISDLAHIEPMYQYSLTWFINLYVQSLANSN--K 3294

  Fly  1075 STMLDWIEKWQALNIKMLLDHGSNLMGAVYRYMRRNERNVMKVPRTIRETVAAKQLFEKLLKDVP 1139
            |..||       |.|:.:::|   ...::|       .||            .:.||||
Mouse  3295 SDELD-------LRIEYIIEH---FTLSIY-------NNV------------CRSLFEK------ 3324

  Fly  1140 VKQSAFTPMLELFVLLHKYQVKLSEETFEQVMGLETAWLHYLQVLEEADEMLDN----------- 1193
             .:..|:.:|.:.:|  |.:..:.||          .|...|    .....|||
Mouse  3325 -DKLLFSLLLTVGLL--KERKAIDEE----------VWYFLL----TGGVALDNPFPNPAPEWLS 3372

  Fly  1194 EDSEAKLLLAKHGEKFKLILKDFLED 1219
            |.|..:::.|...:|.|.:::|.:::
Mouse  3373 EKSWGEIVRASSLQKLKGLMEDVMQN 3398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	130/726 (18%)
Dnah3	NP_001357735.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		DHC_N2	815..1221	CDD:462462
		DYN1	1018..3745	CDD:227570	260/1456 (18%)
		AAA_6	1347..1673	CDD:463697
		AAA 1. /evidence=ECO:0000250	1347..1568
		AAA 2. /evidence=ECO:0000250	1628..1859
		AAA 3. /evidence=ECO:0000250	1992..2240		29/154 (19%)
		AAA 4. /evidence=ECO:0000250	2351..2602		43/258 (17%)
		AAA_8	2360..2620	CDD:463701	44/267 (16%)
		Stalk. /evidence=ECO:0000250	2617..2916		62/330 (19%)
		AAA 5. /evidence=ECO:0000250	3001..3231		30/233 (13%)
		AAA 6. /evidence=ECO:0000250	3444..3668
		Dynein_C	3767..4068	CDD:465677