Protein Alignment CG9068 and Dync1h1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_062099.3
• Gene: Dync1h1 / 29489
• RGDID: 2511
• Length: 4644
• Species: Rattus norvegicus
• Alignment Length: 1296
• Identity: 222/1296 - (17%)
• Similarity: 464/1296 - (35%)
• Gaps: 321/1296 - (24%)

  Fly   108 SDLSYFRREPNEIFSVEGFHDEINFGTLTSDVD-GCLMELLDRLYVPFFRNYLEWNATV---RNR 168
            :.|::.:|.| .|.:.:....::...||:.|.. ..|...:.....|||::|:..:...   .::
  Rat   112 NSLAFIKRAP-VIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDK 175

  Fly   169 FCSSMDRFLAFLS-GMHH-----QISGMSVMYVPFV---------------IKELTAGPVDRYLV 212
            ...|:::.:|.|. |:.|     :|..:|:...|.:               :.:......|...:
  Rat   176 MAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPIITNVAKQCYERGEKPKVTDFGDKVEDPTFL 240

  Fly   213 GSLEGIALYWTTQIR--TLLADDTLTVPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLL 275
            ..|:.....|..:|:  |.|..|..:     .|...|..||......|..|.::....:|...|.
  Rat   241 NQLQSGVNRWIREIQKVTKLDRDPAS-----GTALQEISFWLNLERALYRIQEKRESPEVLLTLD 300

  Fly   276 LLHNAQSVHMP-QMDGLIERARKELHKSLSNIKYLHLLIE--PCSKIDAATSPADLTKLLPRIIH 337
            :|.:.:..|.. ..|     ....|.::|..:...:.|::  |.:.:.:||....:.:.|..|..
  Rat   301 ILKHGKRFHATVSFD-----TDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAIFT 360

  Fly   338 LIRFIWLNSEY--YNTTRLIAALFRNLSNQIIRFCTKQTKVEEILSGKPRFGIRICNVAIE---- 396
            .:|.| .|::|  ....||:.|:.|:||:|:::          :|..:     ::.:||.|
  Rat   361 HLRKI-RNTKYPIQRALRLVEAISRDLSSQLLK----------VLGTR-----KLMHVAYEEFEK 409

  Fly   397 ---CCL----TYRGIYDTIS---RDLA----QKHTQMPWELDEGLIFNHIDAFVERLND------ 441
               .|.    |:...|:.:.   ||:.    :::.:|.|.::..  ...:.|.::::..
  Rat   410 VMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPA--HRKLQARLDQMRKFRRQHE 472

  Fly   442 -----VIDICESMIVFGRLDENGSIPKP--------VFGGTCGEELEKIAESVE-VQFLDTLNKL 492
                 ::.:....:........|..|:|        :|.......:|::..:.| |:.:|.|:..
  Rat   473 QLRAVIVRVLRPQVTAVAQQNQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVS 537

  Fly   493 QQNSQAYILNVHRAD------------WYADVAGFRKNMQKLEETVQRLIFNVF----------- 534
            ::.::|:...:.|.|            ...|..|..||..::.....|  ||..
  Rat   538 KEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSR--FNALFVRPHIRGAIR 600

  Fly   535 ----QQVSNVEEMLEALQAMLFYSYRQRGTLRKTYLKET-----SKLWRMFSKEMDATSRKLLEE 590
                |.:..|::.:|:|.......|.|....:.:::::.     |.:|   :|::|   |:|...
  Rat   601 EYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIW---AKQID---RQLTAY 659

  Fly   591 QSR-ESWLSKHVSIALGYRINLERLTWLRDRLKNSEWLPAVKESSPALAKFDALRHEFQ-KEIRL 653
            ..| |..|.|      |:..::|     ..:||...               |:.|.:.. :||
  Rat   660 MKRVEDVLGK------GWENHVE-----GQKLKQDG---------------DSFRMKLNTQEI-- 696

  Fly   654 AYDDWVAKC----CGFSGDLCQRLDRYLVVRSKKFKG------LLECNIDASVLELCEQAQHFER 708
             :|||..|.    .|.||       |...:.|.:.:|      .|:.|....::.|.::.::.:.
  Rat   697 -FDDWARKVQQRNLGVSG-------RIFTIESARVRGRSGNVLKLKVNFLPEIITLSKEVRNLKW 753

  Fly   709 MGFAIPSTMKKLYERYDTIRSLYNGIIKLALSHNRILAVLSDRERKLFRPLIQACDRQ----LAP 769
            :||.:|..:.....:.:.:......:|:...::.|....:  .||.....|:....::    :|.
  Rat   754 LGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKV--EERNTISLLVAGLKKEVQALIAE 816

  Fly   770 GVFKITYGSEFNEEFFEDGTEFIAEFQE----LVLIFKRANRGVARICEKICGTCLL-HFAFSGS 829
            |: .:.:.|...:.:.:...|.:..|||    |::|.::.:..|..:     .||:. |..||
  Rat   817 GI-ALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSL-----ETCMYDHKTFS-- 873

  Fly   830 VDISVFQQQLSSRLSSSGDILRSY-YSHVVELLSAFSGQFQSVDDEMSAEWIAYVNDMDDMLASS 893
                    ::.:|:..:.|.|..: ||::.                      .:||.:|..:...
  Rat   874 --------EILNRVQKAVDDLNLHSYSNLP----------------------IWVNKLDMEIERI 908

  Fly   894 LMTSARGSLNKLYEALHCDA-DMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLD 957
            |....:..|....:.|...| |.|.     |:.|....::...|..:   ..|..:|..:| :.:
  Rat   909 LGVRLQAGLRAWTQVLLGQAEDKAE-----VDMDTDAPQVSHKPGGE---PKIKNVVHELR-ITN 964

  Fly   958 QFPRLG-------YK------------LKLPKKQQRQGFASVFREDQECSELMR----------- 992
            |...|.       ||            |.||:.|.::....|..|..|..:..|
  Rat   965 QVIYLNPPIEECRYKLYQEMFAWKMIVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPV 1029

  Fly   993 ----SIQAEIGIQREELAKYESEWNKNRVLWQTTEEEFRQRL---MSKSRTAGVFEGGIEHYSAL 1050
                |..|.:||. .|:.:|...|.:.:.||....|....||   :||             :.||
  Rat  1030 ALEESYSAVMGIV-TEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLSK-------------WQAL 1080

  Fly  1051 ADDV-----IFEDAITNVYF--ILINQNALKSTMLDWIEKWQALNIKMLLDHGSNLMGA-VYRYM 1107
            ...:     .|::|.|...|  ::|:...::|.:....:.|.    |.:|.....::|: :..:.
  Rat  1081 LVQIRRARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWH----KEVLSKFGQMLGSNMTEFH 1141

  Fly  1108 RRNERNVMKVPRTIRETVAAKQ--LFEKLLKDVPVKQSAFTPMLELFVLLHKYQVKLSEETFE-- 1168
            .:..::..::.:...:|.:...  .|...::.:..|...|...:||:   ...|..|.::.|:
  Rat  1142 SQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELY---RNGQRLLEKQRFQFP 1203

  Fly  1169 ----QVMGLETAWLHYLQVLEEADEMLDNEDSEAKLLLAKHGEKFKLILKDFLEDFYSKLP 1225
                .:..:|..|..:..::...|..:..:.:..::.:.:.....:....|.|.|:....|
  Rat  1204 PSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKP 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	115/664 (17%)
Dync1h1	NP_062099.3	Stem. /evidence=ECO:0000250	2..1865		222/1296 (17%)
		DHC_N1	240..830	CDD:462457	115/664 (17%)
		Interaction with DYNC1I2. /evidence=ECO:0000269|PubMed:10893223	446..701		48/293 (16%)
		Interaction with DYNC1LI2. /evidence=ECO:0000269|PubMed:10893223	649..800		36/191 (19%)
		DYN1	1044..4327	CDD:227570	38/241 (16%)
		AAA 1. /evidence=ECO:0000250	1866..2097
		AAA 2. /evidence=ECO:0000250	2178..2450
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2389..2409
		AAA 3. /evidence=ECO:0000250	2554..2803
		AAA 4. /evidence=ECO:0000250	2897..3166
		Stalk. /evidence=ECO:0000250	3187..3498
		AAA 5. /evidence=ECO:0000250	3551..3780
		AAA 6. /evidence=ECO:0000250	4003..4219
		Dynein_C	4331..4642	CDD:465677