Protein Alignment CG9068 and DNAH1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: XP_016861618.1
• Gene: DNAH1 / 25981
• HGNCID: 2940
• Length: 4288
• Species: Homo sapiens
• Alignment Length: 1370
• Identity: 236/1370 - (17%)
• Similarity: 451/1370 - (32%)
• Gaps: 449/1370 - (32%)

  Fly    27 PRQEEIRPETPKPSYSDEELNQLV---GYIQRMSVLSCLDHRDWQEGTLDIIRGWLLEVHEPLLT 88
            ||:.||  |..|..|...::.||:   |......:...|||:..|  |::       :.|:|:..
Human   187 PRKIEI--ERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQ--TIE-------QGHDPIFP 240

  Fly    89 IYYDRDALAACLGMPSMCVSDLSYFRREPNEIFSVEGF-----HDEINFGTLTSDVDGCLMELLD 148
            ||.                         |.::|..|.|     .:.||.|.....        ||
Human   241 IYL-------------------------PLKVFDNEDFDCRTPREWINMGLEPGS--------LD 272

  Fly   149 RLYVPFFRNYLEWNATVRNRFCSSMDRFLAFLSGMHHQISGMSVMYVPFVIKELTAGPVD----- 208
            |..||             .:.....|.||.     |.......:.|     |....|.:|
Human   273 RKPVP-------------GKALLPTDDFLG-----HEDPKSQKLKY-----KWCEVGVLDYDEEK 314

  Fly   209 -RYLVGSLEGIALYWTTQIRTLLADDTLTVPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQK 272
             .|||...:...|......|.:|.....|.....:.|   .::|..|.::|....|....:  |:
Human   315 KLYLVHKTDEKGLVRDEMGRPILNAGVTTEGRPPLQV---CQYWVPRIQLLFCAEDPCMFA--QR 374

  Fly   273 VL-----------LLLHNAQSVHMPQ------------------------------MDGLIERAR 296
            |:           |||:|.....||.                              ::.|...||
Human   375 VVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMRKGPSVLEHLSSLAR 439

  Fly   297 K---ELHKSLSNIKYLHLLIEPCSKIDAATSPADLTKLLPR--IIHLIRF-IWLNSEYYNTTRL- 354
            :   :..:|::.|.:.|::..........|.|....:.:|.  ::.:.:: .|...|.:....|
Human   440 EVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLL 504

  Fly   355 -----IAALFRNLSNQIIRFCTKQTKVEEILSGKPRFG------------------------IRI 390
                 |.||     :::...|.|.|.:....|...::.                        |..
Human   505 TRPEVITAL-----SKVRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISS 564

  Fly   391 CNVAIECCLT-----YRGIYDT-----ISRDLAQKHTQMPWELDEGLIFNHIDAFVERLNDVIDI 445
            ..||:...|.     :..:|:|     :...|.:....:.:.|.:.|.|...|:.......:.|.
Human   565 LKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKYMLQDTLRFLVQDSLASFSQFISDT 629

  Fly   446 CESMI------VFGRLDENGSIP-----KPVFGGTCGEELEKIAESVEVQFLDTLNKLQQNSQAY 499
            |.|::      |:|  |:..:.|     .|:|      .::.:.:|..|.:...|.:.    :|.
Human   630 CCSVLNCTDDMVWG--DDLINSPYRPRKNPLF------IMDLVLDSSGVHYSTPLEQF----EAS 682

  Fly   500 ILNVHRADWYADVAGFRKNMQKLEETVQRLIF----NVFQQVSNVEEMLEALQAMLFYSYRQRGT 560
            :||:......|..|     :.:||:.|...||    .:.:.|...|.::|.|:|.:..:..:...
Human   683 LLNLFDKGILATHA-----VPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMI 742

  Fly   561 LRKTYLKETSKLWRMFSKEMDATSRKLLEEQSRESWLSKHVSIALGYRINLERLTWLRDRLKNSE 625
            ..:.|.||..|...:.:.::    ...|:....:..|::.|...:        ||.||::.....
Human   743 PLQAYAKEYRKYLELNNNDI----ASFLKTYQTQGLLAQEVREVV--------LTHLREKEILDS 795

  Fly   626 WLPAVKESSPALAKFDALRHEFQKEIRLAYDDWVAKCCGFSGDLCQRLDRYLVVRSKKFKGL--- 687
            .||:.....|.....|.::...                                 |||.|.|
Human   796 SLPSSIIIGPFYINTDNVKQSL---------------------------------SKKRKALATS 827

  Fly   688 ----LECNIDASVLELCEQAQHFERMGFAIPSTMKKLYERYDTIRSLYNGIIKLALSHNRILAVL 748
                |..|:...|..:||:.:...|..:..|:::::|.|..:.::.:...::.|   ..||:.|:
Human   828 VLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIPERLVGL---EERIVKVM 889

  Fly   749 SDRERKLFRPLIQACDRQLAPGVFKITYGSEFNEEFF--------------------EDGTEFIA 793
            .|         .|..|..|    :.:: ..:||:::.                    ||..:|
Human   890 DD---------YQVMDEFL----YNLS-SDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKF-- 938

  Fly   794 EFQELVLIFKRANRGVARICEKICGTCLLHFAFSGSVDISVFQQ------QLSSRLSSSGDILRS 852
               ..:.|..:.|     ..||:.|..|:...||..|:||...:      ::..:|.....:...
Human   939 ---RKIQIMDQNN-----FQEKLEGLQLVVAGFSIHVEISRAHEIANEVRRVKKQLKDCQQLAML 995

  Fly   853 YYSHV---------VELLSAFSGQFQSVDD--EMSAEWI----AYVNDMDDMLASSLMTSARGSL 902
            |.:..         .:.||....:||...|  ..:::|:    :::||
Human   996 YNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMND----------------- 1043

  Fly   903 NKLYEALHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLDQFPRLGYKLK 967
                            |:..::::                .:...:|::.::|
Human  1044 ----------------PLSAIDAE----------------QLEKNVVEAFKTM------------ 1064

  Fly   968 LPKKQQRQGFASVFREDQECSELMRSIQAEIGIQREELAKY----ESEWNKNRVL--WQTTEEEF 1026
              .|..:|     |::...|.|:...|:|.|    ||...|    :...|....:  |:|...:.
Human  1065 --HKCVKQ-----FKDMPACQEVALDIRARI----EEFKPYIPLIQGLRNPGMRIRHWETLSNQI 1118

  Fly  1027 RQRLMSKSRTAGVFEGGIEHYSALADDVIFEDAITNVYFILINQNALKSTMLDWIEK-WQALNIK 1090
            ...:..|:..  .|...:|  ..|.|.:   ::|:.|..:...:.|::.. ||.:|| |
Human  1119 NINVRPKANL--TFARCLE--MNLQDHI---ESISKVAEVAGKEYAIEQA-LDKMEKEW------ 1169

  Fly  1091 MLLDHGSNLMGAVYRYMRRNERNVMKVPRTIRETVAAKQLFEKLLKDVPVKQSAFTPMLELF--- 1152
                  |.::..|..| :..:..::|.|.      .|.||.:..:  |..:..:|:|..:.|
Human  1170 ------STILFNVLPY-KATDTYILKSPD------EASQLLDDHI--VMTQNMSFSPYKKPFEQR 1219

  Fly  1153 VLLHKYQVKLSEETFEQVMGLETAWLHYLQVLEEADEMLDNEDSEAKL-LLAKHGEKFKLILKDF 1216
            :...:.::||::|..|:.:..:.:|| ||      :.:..:||...:| :.:|..:..:.|.|..
Human  1220 INSWENKLKLTQEVLEEWLNCQRSWL-YL------EPIFSSEDINQQLPVESKRYQTMERIWKKI 1277

  Fly  1217 LEDFY 1221
            :::.|
Human  1278 MKNAY 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	114/680 (17%)
DNAH1	XP_016861618.1	DHC_N2	1013..1416	CDD:462462	65/378 (17%)
		DYN1	<1252..3921	CDD:227570	7/31 (23%)
		AAA_6	1543..1869	CDD:463697
		AAA_8	2579..2840	CDD:463701
		Dynein_C	3982..4284	CDD:465677