Protein Alignment CG9068 and DNAH12

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001352957.1
• Gene: DNAH12 / 201625
• HGNCID: 2943
• Length: 3960
• Species: Homo sapiens
• Alignment Length: 1615
• Identity: 297/1615 - (18%)
• Similarity: 514/1615 - (31%)
• Gaps: 592/1615 - (36%)

  Fly     8 EDEHLTDS---DLTDDEERS----------VEPRQEEIR------PETP------KPSYSDEELN 47
            |.|.|.:|   :::.|.|.|          |:|..:.:.      ||:|      .|.:|
Human   132 EREELLESLINEVSSDFENSMKRYLVQSVLVKPPVKSLEDEGGPLPESPVGLDYSNPWHS----- 191

  Fly    48 QLVGYIQ-RMSVLSCLDHRDWQEGTLDIIRGWLLEVHEPLLTIYYDRDALAACLGM-------PS 104
               .|:| |..:.|          .|.||...:    :.||.:.|...|....|..       |.
Human   192 ---SYVQARNQIFS----------NLHIIHPTM----KMLLDLGYTTFADTVLLDFTGIRAKGPI 239

  Fly   105 MCVS---DLSYFRREPNEIFSVEGFHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVR 166
            .|.|   |||...|...|......:...||..|....::|...|.||..|
Human   240 DCESLKTDLSIQTRNAEEKIMNTWYPKVINLFTKKEALEGVKPEKLDAFY--------------- 289

  Fly   167 NRFCSSMDRFLAFLSGMHHQISGMSVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLLA 231
              .|.|        :.|.:|:..:....|...:|........|..:..:|            |..
Human   290 --SCVS--------TLMSNQLKDLLRRTVEGFVKLFDPKDQQRLPIFKIE------------LTF 332

  Fly   232 DDTLTVPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLLHNAQSV------------- 283
            ||            |:.||    |...|.:.|.:. |.|:::...|.|.|::
Human   333 DD------------DKMEF----YPTFQDLEDNVL-SLVERIAEALQNVQTIPSWLSGTSTPVNL 380

  Fly   284 --HMPQ------MDGL-------IERARKELHKSLSNIKYL----------------HLLIEPCS 317
              .:|:      :|.|       :|.|||.....:....:|                |...|...
Human   381 DTELPEHVLHWAVDTLKAAVHRNLEGARKHYETYVEKYNWLLDGTAVENIETFQTEDHTFDEYTE 445

  Fly   318 KIDAATSPADLTKLLPRIIH--LIRF------------------IWLN---SEYYNTTRLIAALF 359
            .|:...|.|....|||:.||  ::|.                  |.||   |:|......|.:.|
Human   446 FIEKFLSLASEIMLLPQWIHYTMVRLDCEDLKTGLTNKAKAFANILLNDIASKYRKENECICSEF 510

  Fly   360 RNLSNQIIRFCTKQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISR-------------- 410
            ..:....::......::.:::|            .:|...|. ||.:.|.|
Human   511 EAIKEHALKVPETTEEMMDLIS------------YVEKARTV-GIEELILRIQESKRQMSYFLDV 562

  Fly   411 ------DLAQKHTQMPWELDEGLIFNHIDAFVE-----RLNDVIDICESMIV------------- 451
                  |||...|.:.|......||:..|..:|     :.|:::...|.:|:
Human   563 FLFPQEDLALNATVLMWPRKINPIFDENDELIENAKHKKENELMAKREKLILEIEKESRRMEEFT 627

  Fly   452 -FGRLDENGSIPKPVFGGTCGEELEK-IAESVE-VQFLD--------------TLNKLQQNSQAY 499
             |..|:........|      .:|:| |.||.| |||::              .|:||:.|.:.|
Human   628 EFAELERMQQYVTDV------RQLQKRIQESEEAVQFINKEEELFKWELTKYPELDKLKVNIEPY 686

  Fly   500 ------ILNVHRAD--W----YADVAGFRKNMQKLEETVQRLIFNV--FQQVSNVEEMLEALQAM 550
                  :|...|::  |    :.|:.|  ::|:...|...|.||..  |.|....:|:.|..:|.
Human   687 QKFFNFVLKWQRSEKRWMDGGFLDLNG--ESMEADVEEFSREIFKTLKFFQTKLKKELQEKRKAA 749

  Fly   551 LFYSY---------RQRGTLR------------KTYLKETSKL---------WRMFSK------- 578
            ...|.         :...|:.            |.|:...|.|         |:..|:
Human   750 RKRSLEEEKIEEEPKDNATITMCSTVMEQIKAFKEYIPTVSILCNPGMRARHWKQISEIVGYDLT 814

  Fly   579 -EMDATSRKLLE-------EQ--------SRESWLSKHVSIALG------YRINLERLTW----- 616
             :...|.||:|:       ||        |:|..|.|.::..:|      :.|:|.|.|.
Human   815 PDSGTTLRKVLKLNLTPYLEQFEVISAGASKEFSLEKAMNTMIGTWEDIAFHISLYRDTGVCILS 879

  Fly   617 --------LRDRLKNSEWLPAVKESSPALAKFDALRHEFQK------EIRLAYDDWVAK------ 661
                    |.|::..::.:    ..||.:..|:   ||.:.      .|:...|:|:..
Human   880 SVDEIQAILDDQIIKTQTM----RGSPFIKPFE---HEIKAWEDRLIRIQETIDEWLKVQAQWLY 937

  Fly   662 -----CCGFSGDLCQRL---DRYLVVRSKKFKGLLE-CNIDASVLE------LCEQAQHFERMGF 711
                 |   |.|:.|::   .|......:.::.::: |..|..||.      |.|:.|:...:
Human   938 LEPIFC---SEDIMQQMPEEGRQFQTVDRHWRDIMKFCAKDPKVLAATSLTGLLEKLQNCNEL-- 997

  Fly   712 AIPSTMKKLYERYDTIRSLYNGIIKLALSHNRILAVLSDRERKL-FRPLIQACDRQLAPGVF--- 772
             :...||.|....:..|..:...  ..||::.:|.:||:.:..| .:|.::.|...:|...|
Human   998 -LEKIMKGLNAYLEKKRLFFPRF--FFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLPN 1059

  Fly   773 ---KITYGSEFNEEFFEDGTEFIAEFQELVLIFKRANRG------------VARICEKICGTCLL 822
               |..|.||      .:..|.||      ||...|.||            :.|....:.....|
Human  1060 LDIKAMYSSE------GERVELIA------LISTSAARGAVEKWLIQVEDLMLRSVHDVIAAARL 1112

  Fly   823 HFAFS----------GSVDISVFQQQLSSR----LSSSGDILRSYY-------SHVVELL-SAFS 865
            .:..|          |.|.:.:.|...:|.    :|...:.|:.||       :.:|||: ...|
Human  1113 AYPESARRDWVREWPGQVVLCISQMFWTSETQEVISGGTEGLKKYYKELQNQLNEIVELVRGKLS 1177

  Fly   866 GQFQSV------------DDEMSAEWIAYVNDMDDMLASSLMTSARGSLNKLYEALHCDADMA-- 916
            .|.::.            |..|....:...:|.|.:..:.|....... |.....::|:...|
Human  1178 KQTRTTLGALVTIDVHARDVVMDMIKMGVSHDTDFLWLAQLRYYWENE-NARVRIINCNVKYAYE 1241

  Fly   917 ---SAPIIVV-----------------------ESDVKDGRIVFTPDMD---------------- 939
               ::|.:|:                       |.....|:...|.|:.
Human  1242 YLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGL 1306

  Fly   940 ---AIGDMINGIVDS-IRSMLDQFPRLGYKLKLPKKQQRQGFASVFREDQECSELMRSIQAEIGI 1000
               |:|....|:..| ..:..|:|.|:..::           .||..:...|  :.|:||.::.:
Human  1307 DYLAMGKFFKGLASSGAWACFDEFNRIELEV-----------LSVVAQQILC--IQRAIQQKLVV 1358

  Fly  1001 ---QREELAKYESEWNKNRVLWQTT------EEEFRQRLMSKSRTAGVFEGGIEHYSALADDVIF 1056
               :..||     :.|.|..:..|.      ..|....|....||..:.   :.:|:.:|:..::
Human  1359 FVFEGTEL-----KLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMM---VPNYALIAEISLY 1415

  Fly  1057 EDAITNVYFILINQNALKSTMLDWIEKWQALNIKMLL---------------DHGSNLMGAV--- 1103
            .....|.                     :.|::|:::               |:|...:.||
Human  1416 SYGFLNA---------------------RPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVA 1459

  Fly  1104 -----YRYMRRNERNVMKVPRTIRETVAAKQLFEKLLKDVPVKQSAFTPMLELFVLLHKYQVKLS 1163
                 .:|...||..::.  |:|::....|.|..    |:|:.....:   :||.     .:||.
Human  1460 AGNLKLKYPNENEDILLL--RSIKDVNEPKFLSH----DIPLFNGITS---DLFP-----GIKLP 1510

  Fly  1164 EETFEQVM--GLETAWLHYLQVLEEADEMLDNEDSEAKLLLAKHGEKFKLILKDF 1216
            |..:.:.:  ..|...:|.||.::   ..|:......::::.:||  |.|:.:.|
Human  1511 EADYHEFLECAHEACNVHNLQPVK---FFLEKIIQTYEMMIVRHG--FMLVGEPF 1560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	155/813 (19%)
DNAH12	NP_001352957.1	PRK03918	<591..>752	CDD:235175	37/168 (22%)
		DHC_N2	676..1110	CDD:462462	92/462 (20%)
		DYN1	891..3605	CDD:227570	131/759 (17%)
		AAA_6	1238..1564	CDD:463697	62/384 (16%)
		AAA_8	2246..2506	CDD:463701
		AAA_9	2894..3115	CDD:463702
		Dynein_C	3655..3956	CDD:465677