Protein Alignment CG9068 and dhc-1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_491363.1
• Gene: dhc-1 / 172041
• WormBaseID: WBGene00000962
• Length: 4568
• Species: Caenorhabditis elegans
• Alignment Length: 1600
• Identity: 280/1600 - (17%)
• Similarity: 517/1600 - (32%)
• Gaps: 597/1600 - (37%)

  Fly    19 DDEERSVEPRQEEIR-------PETPKPSYSDEELNQLVG----YIQRMSVLSCLDHR----DWQ 68
            |.:.:|.|...:.||       |...:....|.|: ||.|    ::.::..:....||    |..
 Worm  2447 DGKWKSREMMSDFIRQATTISLPPNQQACLIDYEV-QLSGDWQPWLSKVPTMEIESHRVAAADLV 2510

  Fly    69 EGTLDIIR------GWLLEVHEPL-----------LTIYYDRDALAACLGMPSMCVSDLSY---- 112
            ..|:|.:|      .||.| |:||           :|:      |||......|.|.::::
 Worm  2511 VPTIDTVRHEMLLAAWLAE-HKPLVLCGPPGSGKTMTL------LAALRSQQEMEVVNVNFSSST 2568

  Fly   113 --------------FRREPNEIFSVEG--------FHDEIN------FGTLTSDVDGCLMELLDR 149
                          :||.||.:.....        |.||||      :||              :
 Worm  2569 TPELLLRTFDHYCEYRRTPNGVVLAPVQLSQWLVIFCDEINLPAPDKYGT--------------Q 2619

  Fly   150 LYVPFFRNYLEWNATVRNRFCS--SMDRFLAFLSGMH-------HQISGMSVMYVPFVIKELTAG 205
            ..:.|.|..:|.|...|....|  |::| :.|:...:       |.::...:.:||.|..:....
 Worm  2620 RVISFLRQLVELNGFYRTSDHSWVSLER-IQFVGACNPPTDPGRHPMTSRFLRHVPIVYVDYPGQ 2683

  Fly   206 PVDRYLVGSLEGIALYWTTQIRTLLADDTLT------------------VPHDLVTVRDEFEFWE 252
            ...:.:.|:.....|..|..:|.|.  |.||                  .||.:.:.| |...|
 Worm  2684 TSLQQIYGTFNRAMLKMTPAVRGLA--DQLTNAMVDVYLASQEHFTQDDQPHYVYSPR-ELTRW- 2744

  Fly   253 YRYEVLQGINDQL----AHSDVQKVLLLLHNAQSVHMPQMDGLIERARKELHKSLSNIKYLHLLI 313
                 ::||::.:    :.|..|.|.|..|.|  :.:.| |.|:....:|....|.:........
 Worm  2745 -----VRGISEAITPLESLSAEQLVRLWAHEA--IRLFQ-DRLVTEEEREWTDKLVDTTAERYFG 2801

  Fly   314 EPCSKIDAATSPADLTKLLPRIIHLIRFIWLNSEYYNTTR-----LIAA---------------L 358
            ..|...:|...|            |:...||:..|...||     .::|               |
 Worm  2802 NACRLDEALKRP------------LLYSCWLSRNYVPVTREELQDYVSARLKGFYEEELDVKLVL 2854

  Fly   359 FRNLSNQIIRF--CTKQTKVEEILSGK--------PRF-----GIRICNVAIECCLTYRGIYD-- 406
            |..:.:.::|.  ..:|::...:|.|.        .||     |:.:..:.:....|.....:
 Worm  2855 FDQMLDHVLRIDRIYRQSQGHLLLIGTAGAGKTTLSRFVAWLNGLSVFQLKVHSKYTAADFDEDM 2919

  Fly   407 -TISRDLAQKHTQMPWELDEGLIFNHID-AFVERLNDVIDICESMIVFGRLDENGSIPKPVFGGT 469
             |:.|....::.::.:.:||.   |.:| .|:||||.::             .||.:|....|..
 Worm  2920 RTVLRRAGCRNEKLCFIMDES---NMLDTGFLERLNTLL-------------ANGEVPGLFEGDE 2968

  Fly   470 CGEELEKIAESVEVQ--FLDTLNKLQQ-NSQAYILNVH--------------RA----------- 506
            ....:.:|.|..:.|  .||:.::|.: .:|..:.|:|              ||
 Worm  2969 HTTLMTQIKEGAQRQGLILDSHDELYKWFTQQVMRNLHVVFTMNPSGSGLRERASTSPALFNRCV 3033

  Fly   507 -DWYAD----------------------------------------------------------- 511
             :|:.|
 Worm  3034 LNWFGDWSENALYQVGSELTRTMDLDRTDYEGSVRLTPSCELVPSQPTYRDAVVNTLCLVHKTVQ 3098

  Fly   512 ----------------------------VAGFRKNMQKLEETVQRLIFNV-FQQVSNVEEMLEAL 547
                                        ::.|.:....|||  :::..|: ..::|..||.::.|
 Worm  3099 KFNEMETKKGHRVMACTPRHFLDFIKQFMSLFHEKRSDLEE--EKIHLNIGLNKISETEEQVKEL 3161

  Fly   548 QAMLFYSYRQRGTLRKTYLKETSKLWRMFSKEMDATSRKLLEEQSRESWLSKHVSIALGYRINLE 612
            |..|        .|:...|:|..:...:..|||....:|..||:.....|.|.::..|  :...|
 Worm  3162 QKSL--------KLKSNELQEKKEAANLKLKEMLGDQQKAEEEKKFSEQLQKELAEQL--KQMAE 3216

  Fly   613 RLTWLRDRLKNSEWLPAVKE-------------------SSPAL------------------AKF 640
            :.|::.:.|...|  |||.|                   |||.:                  ..:
 Worm  3217 KKTFVENDLAQVE--PAVAEAQTAVQGIKKSQLVEVKSMSSPPVTVKLTLEAICILLGENVGTDW 3279

  Fly   641 DALRHEFQKEIRLAYDDWVAKCCGFSGDL-----CQRLDRYLVVRSKKFKGLLECNIDASVLELC 700
            .|:|....|      ||::.:...|..:|     .:::::|:.....:|..:...::....:...
 Worm  3280 KAIRQVMMK------DDFMTRILQFDTELLTPEILKQMEKYIQNPDWEFDKVNRASVACGPMVKW 3338

  Fly   701 EQAQHFERMGFAIPSTMKKLYERYDTIRSLYNGIIKLALSHNRILAVLSDRERKLFRPLIQACDR 765
            .:||       .:.|||  |::    :..|.|.:.:|...     |....:|.|:....|...:.
 Worm  3339 ARAQ-------LLYSTM--LHK----VEPLRNELKRLEQE-----AAKKTQEGKVVDVRITELEE 3385

  Fly   766 QLAPGVFKITYGSEFNEEFFEDGTEFIAEFQELVLIFKRANR--------------------GVA 810
            .:  |.:|..|.....:      .|.|.  |:|:.:.::.||                    |.:
 Worm  3386 SI--GKYKEEYAQLIGQ------AENIK--QDLLSVQEKVNRSTELLSSLRSERDRWSSGSAGFS 3440

  Fly   811 RICEKICGTCLLHFAFSGSVDISVFQQQLSSRLSSSGDILRSYYSHVV-------------ELLS 862
            :..:.:.|..||..||....  ..:.|.|..      :|...:::|||             |.||
 Worm  3441 QQMDSLVGDALLSSAFLAYA--GYYDQMLRD------EIFHKWFNHVVNAGLHFRHDLARIEYLS 3497

  Fly   863 AFSGQFQ------SVDD-------------------EMSAEWIAYV------------NDMDDML 890
            ....:.|      .|||                   :.|.:.:.|:            :.:|:..
 Worm  3498 TVDDRLQWQLNSLPVDDLCTENAIMLHRFNRYPLIIDPSGQAVEYIMKQFAGKNIQKTSFLDESF 3562

  Fly   891 ASSLMTSARGSLNKLYEALHC-------------------------DADMASAPIIVVESDVKDG 930
            ..:|.::.|...:.|.:.:..                         |.|:..:|...:....:|.
 Worm  3563 RKNLESALRFGNSLLVQDVEAYDPILNPVLNREVKRAGGRVLITIGDQDIDLSPSFQIFMITRDS 3627

  Fly   931 RIVFTPDMDAIGDMINGIVDSIRSMLDQFPRLGYKLKLPKKQQRQGFASVFREDQEC-SELMRSI 994
            .:.|:||:.:....:|..|.|                       ...||      :| ::::||.
 Worm  3628 TVEFSPDICSRVTFVNFTVTS-----------------------SSLAS------QCLNQVLRSE 3663

  Fly   995 QAEIGIQREELAKYESEW-----------------NKNRVLWQTTEEEFRQRLMSKSRTAGVFEG 1042
            :.::..:|.:|.|.:.|:                 :|.::|...:..|..::|  |:..|.|.:
 Worm  3664 RPDVDKKRNDLLKLQGEFAVRLRHLEKALLAALNESKGKILDDNSVIETLEKL--KNEAAEVAQ- 3725

  Fly  1043 GIEHYSALADDVIFE-DAITNVYFILINQNALKSTMLDWI-EKWQALN-IKMLLDHGSNLMGAVY 1104
                .||..|.|:.| ||::..|..|       ||....| ...|.|| |..|..:..:.:..::
 Worm  3726 ----KSAETDKVMAEVDAVSAQYQRL-------STACSHIYHTLQQLNEIHFLYHYSLDFLVEIF 3779

  Fly  1105 RYMRRNERNVMKVPRTIRETVAAKQ-------LFEKLLKDVPVKQSAFTPMLELFVLLHKYQVKL 1162
            .:       |:|.|.....|..||:       ||:.:.:.|. :....|..:.|.:||.:..::.
 Worm  3780 TH-------VLKTPELSSTTDYAKRLRIITTSLFQTVFRRVS-RGMLHTDKVLLALLLMRIHIRS 3836

  Fly  1163 --SEETFEQVMGLETAWLHYLQVLEEADEMLDNEDSEAKL 1200
              |...:||         |:..:|..:|.:..|:::::.:
 Worm  3837 NPSAPAYEQ---------HFDLLLGRSDFVAKNDEADSTI 3867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	133/791 (17%)
dhc-1	NP_491363.1	DHC_N1	238..811	CDD:462457
		DYN1	985..4276	CDD:227570	280/1599 (18%)
		Dynein_C	4281..4563	CDD:465677