Protein Alignment CG9068 and Dync1h1

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_084514.2
• Gene: Dync1h1 / 13424
• MGIID: 103147
• Length: 4644
• Species: Mus musculus
• Alignment Length: 1293
• Identity: 220/1293 - (17%)
• Similarity: 462/1293 - (35%)
• Gaps: 315/1293 - (24%)

  Fly   108 SDLSYFRREPNEIFSVEGFHDEINFGTLTSDVD-GCLMELLDRLYVPFFRNYLEWNATV---RNR 168
            :.|::.:|.| .|.:.:....::...||:.|.. ..|...:.....|||::|:..:...   .::
Mouse   112 NSLAFIKRAP-VIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDK 175

  Fly   169 FCSSMDRFLAFLS-GMHH-----QISGMSVMYVPFV---------------IKELTAGPVDRYLV 212
            ...|:::.:|.|. |:.|     :|..:|:...|.:               :.:......|...:
Mouse   176 MAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPIITNVAKQCYERGEKPKVTDFGDKVEDPTFL 240

  Fly   213 GSLEGIALYWTTQIR--TLLADDTLTVPHDLVTVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLL 275
            ..|:.....|..:|:  |.|..|..:     .|...|..||......|..|.::....:|...|.
Mouse   241 NQLQSGVNRWIREIQKVTKLDRDPAS-----GTALQEISFWLNLERALYRIQEKRESPEVLLTLD 300

  Fly   276 LLHNAQSVHMP-QMDGLIERARKELHKSLSNIKYLHLLIE--PCSKIDAATSPADLTKLLPRIIH 337
            :|.:.:..|.. ..|     ....|.::|..:...:.|::  |.:.:.:||....:.:.|..|..
Mouse   301 ILKHGKRFHATVSFD-----TDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAIFT 360

  Fly   338 LIRFIWLNSEY--YNTTRLIAALFRNLSNQIIRFCTKQTKVEEILSGKPRFGIRICNVAIE---- 396
            .:|.| .|::|  ....||:.|:.|:||:|:::          :|..:     ::.:||.|
Mouse   361 HLRKI-RNTKYPIQRALRLVEAISRDLSSQLLK----------VLGTR-----KLMHVAYEEFEK 409

  Fly   397 ---CCL----TYRGIYDTIS---RDLA----QKHTQMPWELDEGLIFNHIDAFVERLND------ 441
               .|.    |:...|:.:.   ||:.    :::.:|.|.::..  ...:.|.::::..
Mouse   410 VMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPA--HRKLQARLDQMRKFRRQHE 472

  Fly   442 -----VIDICESMIVFGRLDENGSIPKP--------VFGGTCGEELEKIAESVE-VQFLDTLNKL 492
                 ::.:....:........|..|:|        :|.......:|::..:.| |:.:|.|:..
Mouse   473 QLRAVIVRVLRPQVTAVAQQNQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVS 537

  Fly   493 QQNSQAYILNVHRAD------------WYADVAGFRKNMQKLEETVQRLIFNVF----------- 534
            ::.::|:...:.|.|            ...|..|..||..::.....|  ||..
Mouse   538 KEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSR--FNALFVRPHIRGAIR 600

  Fly   535 ----QQVSNVEEMLEALQAMLFYSYRQRGTLRKTYLKET-----SKLWRMFSKEMDATSRKLLEE 590
                |.:..|::.:|:|.......|.|....:.:::::.     |.:|   :|::|   |:|...
Mouse   601 EYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIW---AKQID---RQLTAY 659

  Fly   591 QSR-ESWLSKHVSIALGYRINLERLTWLRDRLKNSEWLPAVKESSPALAKFDALRHEFQ-KEIRL 653
            ..| |..|.|      |:..::|     ..:||...               |:.|.:.. :||
Mouse   660 MKRVEDVLGK------GWENHVE-----GQKLKQDG---------------DSFRMKLNTQEI-- 696

  Fly   654 AYDDWVAKC----CGFSGDLCQRLDRYLVVRSKKFKG------LLECNIDASVLELCEQAQHFER 708
             :|||..|.    .|.||       |...:.|.:.:|      .|:.|....::.|.::.::.:.
Mouse   697 -FDDWARKVQQRNLGVSG-------RIFTIESARVRGRTGNVLKLKVNFLPEIITLSKEVRNLKW 753

  Fly   709 MGFAIPSTMKKLYERYDTIRSLYNGIIKLALSHNRILAVLSDRERKLFRPLIQACDRQ----LAP 769
            :||.:|..:.....:.:.:......:|:...::.|....:  .||.....|:....::    :|.
Mouse   754 LGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKV--EERNTISLLVAGLKKEVQALIAE 816

  Fly   770 GVFKITYGSEFNEEFFEDGTEFIAEFQE----LVLIFKRANRGVARICEKICGTCLL-HFAFSGS 829
            |: .:.:.|...:.:.:...|.:..|||    |::|.::.:..|..:     .||:. |..||
Mouse   817 GI-ALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSL-----ETCMYDHKTFS-- 873

  Fly   830 VDISVFQQQLSSRLSSSGDILRSY-YSHVVELLSAFSGQFQSVDDEMSAEWIAYVNDMDDMLASS 893
                    ::.:|:..:.|.|..: ||::.                      .:||.:|..:...
Mouse   874 --------EILNRVQKAVDDLNLHSYSNLP----------------------IWVNKLDMEIERI 908

  Fly   894 LMTSARGSLNKLYEALHCDA-DMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLD 957
            |....:..|....:.|...| |.|.     |:.|....::...|..:   ..|..:|..:| :.:
Mouse   909 LGVRLQAGLRAWTQVLLGQAEDKAE-----VDMDTDAPQVSHKPGGE---PKIKNVVHELR-ITN 964

  Fly   958 QFPRLG-------YK------------LKLPKKQQRQGFASVFREDQECSELMR----------- 992
            |...|.       ||            |.||:.|.::....|..|..|..:..|
Mouse   965 QVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPV 1029

  Fly   993 ----SIQAEIGIQREELAKYESEWNKNRVLWQTTEEEFRQRLMSKSRTAGVFEGGIEHYSALADD 1053
                |..|.:||. .|:.:|...|.:.:.||....|....||..          .:..:.||...
Mouse  1030 ALEESYSAVMGIV-TEVEQYVKVWLQYQCLWDMQAENIYNRLGE----------DLNKWQALLVQ 1083

  Fly  1054 V-----IFEDAITNVYF--ILINQNALKSTMLDWIEKWQALNIKMLLDHGSNLMGA-VYRYMRRN 1110
            :     .|::|.|...|  ::|:...::|.:....:.|.    |.:|.....::|: :..:..:.
Mouse  1084 IRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWH----KEVLSKFGQMLGSNMTEFHSQI 1144

  Fly  1111 ERNVMKVPRTIRETVAAKQ--LFEKLLKDVPVKQSAFTPMLELFVLLHKYQVKLSEETFE----- 1168
            .::..::.:...:|.:...  .|...::.:..|...|...:||:   ...|..|.::.|:
Mouse  1145 SKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELY---RNGQRLLEKQRFQFPPSW 1206

  Fly  1169 -QVMGLETAWLHYLQVLEEADEMLDNEDSEAKLLLAKHGEKFKLILKDFLEDFYSKLP 1225
             .:..:|..|..:..::...|..:..:.:..::.:.:.....:....|.|.|:....|
Mouse  1207 LYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKP 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	115/664 (17%)
Dync1h1	NP_084514.2	Stem. /evidence=ECO:0000250	2..1865		220/1293 (17%)
		DHC_N1	240..830	CDD:462457	115/664 (17%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	446..701		48/293 (16%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	649..800		36/191 (19%)
		DYN1	1044..4327	CDD:227570	36/238 (15%)
		AAA 1. /evidence=ECO:0000250	1866..2097
		AAA 2. /evidence=ECO:0000250	2178..2450
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2388..2408
		AAA 3. /evidence=ECO:0000250	2554..2803
		AAA 4. /evidence=ECO:0000250	2897..3166
		Stalk. /evidence=ECO:0000250	3187..3498
		AAA 5. /evidence=ECO:0000250	3551..3780
		AAA 6. /evidence=ECO:0000250	4003..4219
		Dynein_C	4331..4642	CDD:465677