Protein Alignment CG9068 and DNAH14

DIOPT Version :10

• Sequence 1: NP_611111.1
• Gene: CG9068 / 36817
• FlyBaseID: FBgn0034106
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001354408.1
• Gene: DNAH14 / 127602
• HGNCID: 2945
• Length: 4617
• Species: Homo sapiens
• Alignment Length: 1553
• Identity: 263/1553 - (16%)
• Similarity: 472/1553 - (30%)
• Gaps: 577/1553 - (37%)

  Fly    13 TDSDLTDDEERSVEPR--------QEEIRPETPKPSYSDEELNQLVGYIQRMSVLSCLDHRDWQE 69
            |::...|.||...:||        .|:::|...:|:...|:  :.:.|....:....|.    .|
Human    11 TENQEMDKEETKTKPRLLRYEEKKYEDVKPLETQPAEIAEK--ETLEYKTVRTFSESLK----SE 69

  Fly    70 GTLDIIRGWLLEVH----EPLL-----TIYYDRDALAACLGMPSMCVSDLSYFRREPNEIFSVEG 125
            .|.|.:|..:::.|    ||..     .....:|...||..:..  ...:||.|.||.:
Human    70 KTEDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRK--ARPVSYDRTEPKD------ 126

  Fly   126 FHDEINFGTLTSDVDGCLMELLDRLYVPFFRNYLEWNATVRNRFCSSMDRFLAFLSGMHHQISGM 190
                       .||...::.|         |..|.|..                :...|....|.
Human   127 -----------DDVIRNIIRL---------REKLGWQT----------------ILPQHSLKYGS 155

  Fly   191 SVMYVPFVIKELTAGPVDRYLVGSLEGIALYWTTQIRTLLADD-------------TLTVPHDLV 242
            |    ...|:::|                      ::..|.||             :|..|:||.
Human   156 S----KIAIQKIT----------------------LKKPLEDDGEFVYCLPRKSPKSLYNPYDLQ 194

  Fly   243 -----TVRDEFEFWEYRYEVLQGINDQLAHSDVQKVLLLLHNAQSVHM-PQMDGLIERARKELHK 301
                 |.:...|||            .:..|.:.||:.::.:.:.|.: |.::.|.||
Human   195 VVSAHTAKHCKEFW------------VITASFISKVINIVGSVKEVELIPTLEWLSER------- 240

  Fly   302 SLSNIKYLHLLIEPCSKIDAATSPADLTKLLPRIIHLIRFIW-LNSEYYNTTRLIAALFRN--LS 363
                 ::.:||.:.....|...:.|.:|             | ||.:...|.:..:.|:.:  |:
Human   241 -----RHYYLLRQFKIFSDFRMNKAFVT-------------WKLNVKRIKTEKSRSFLYHHLFLA 287

  Fly   364 NQIIRFC--------------TKQTKVEEILSGKPRFGIRICNVAIECCLTYRGIYDTISRDLAQ 414
            :.:.:.|              ......|..||.       ||.|.::...||.  .|....:..|
Human   288 DDLFQTCLVYIRGLCEDAINLKNYNDHENNLSA-------ICLVKLDSSRTYS--LDEFCEEQLQ 343

  Fly   415 KHTQMPWELDEGLIFNHIDAFVERLNDVID--ICESMIVFGRLDENGSIPKPVFGGTCGEE---- 473
            :.||.                :::|.|:.:  |.|....|.::.|...| |..|.....|:
Human   344 QATQA----------------LKQLEDIRNKAISEMKSTFLKVAEKNEI-KEYFESKLSEDDTTH 391

  Fly   474 ---------LE---KIAESVEVQFLDTLNKLQQNSQAYILNVHRADWYADVAGFRKNMQKLEETV 526
                     ||   |....|:..|.:.:.:|...:...:|.:....     ||...:::|..|.:
Human   392 FKLPKYRRLLETFFKFVMLVDYIFQELIRQLMNTAVTLLLELFNGS-----AGMPFSVEKKNENL 451

  Fly   527 QRLI----FNVFQQVSNVEEMLE--ALQAM---------------LFYSYRQRGTLRKTYL---- 566
            .|..    |...:..::.||:::  .|.|:               :..|......|||||.
Human   452 IRTFKDNSFPTGKTTNDCEELVDNSKLHAISVQKSEVKTDTDINEILNSVEVGKDLRKTYAPIFE 516

  Fly   567 -------------KETSK-----------LWRMFSKEMDATSRKLLEEQSRESWL-----SKHVS 602
                         .|.||           ...||..||.......:::.|.|..|     ||.:|
Human   517 VNLCLRIPAESDSSENSKENFHESDQCPEECVMFEDEMSENKDNCVKKHSSEELLPKAKKSKEIS 581

  Fly   603 IALGYRINLERL---TWLRDRLKNSEWLPAVKESSPALAKFDALRHEFQKEIRLAYDDWVAKCCG 664
                  .|||.:   |.:....:|........| .|.....|..|.||..:|:....: :.||..
Human   582 ------YNLEDIISDTEIETEFENKYMYYEFPE-FPTNLFIDPNRLEFSVKIQNMLTN-MEKCIT 638

  Fly   665 FSGDLCQ--RLDRYL--------------VVRSKKFKGLLEC-----------NIDASVLEL--- 699
            ....|||  :|..::              ::..|:.....:|           ||..::|.:
Human   639 TITPLCQDPQLSIFIDLVSIMDLPNKTGSIIHYKEQTRWPDCHILFETDPAYQNIIVNLLTIIGN 703

  Fly   700 ---------------CEQAQHFERMGFAIPS----TMKKLYERYDTIRSLYNGIIKLA------- 738
                           |...:..:.|...|.|    |.|:.....:..|:.:..|:.:|
Human   704 SMGLVNAYSHKFIKYCTMTEKAKIMSMKISSMGELTSKEFEAILNRFRNYFRHIVNMAIEKRIGI 768

  Fly   739 ---------------------LSHNRILAVLSDRERKLFRPLIQACDRQLAPGVFKITYGSEFNE 782
                                 :||..|.:|:..:.:.|.. ::::..:||..
Human   769 FNVVSLDYQSECLLYIDNVIHMSHTLIQSVIEKKNKNLLE-VVESSLQQLEC------------- 819

  Fly   783 EFFEDGTEFIAEFQELVLIFKRANRGVARICEKICGTCLLHFAFSGSVD--ISVFQQQLSSRLSS 845
                |.|| |.||.|                         ||.|..::.  ||..:::..: :|.
Human   820 ----DPTE-IEEFLE-------------------------HFIFLNAISSKISKLEKEFLT-MSQ 853

  Fly   846 SGDILRSYYSHVVE----LLSAFSGQFQSVDDEMSAEWIAYVNDMDDMLASSLMTSARGSLNKLY 906
            ...:.:.:..|:.|    :......:|..:...|.   ::.:|      ..:.:|..|.:|....
Human   854 LYSVAKHHQIHISEEQIAIFQVLLLKFSQLKSSMK---LSKIN------KDTAITKFRDNLEACI 909

  Fly   907 EALHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGDMINGIVDSIRSMLDQFPRLGYKLKLPKK 971
            ..||.|.....|.|             .||.:...|..::..::.|:::..:...|..|.|....
Human   910 SGLHVDVGNLKAKI-------------RTPLLLCAGTQVSTAMEMIQTLSGEAASLTNKAKAYSH 961

  Fly   972 QQRQGFASVFREDQ------ECSELMRSIQAEIG------IQREELAKYESEWNKNRVLW----- 1019
            .|     ..|.:.|      ...|:.:.:.:||.      ..|::|.:.:.||.:....|
Human   962 YQ-----DCFSDSQSHMHSVNVEEITQIVLSEISDIEGDLTLRKKLWEAQEEWKRASWEWRNSSL 1021

  Fly  1020 QTTEEEFRQRLMSK-SRTAGVFEGGI---------------------------------EHYSAL 1050
            |:.:.|..||.:|| .....|.|.|:                                 .|:.||
Human  1022 QSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELPIIIALGNPCLKPRHWEAL 1086

  Fly  1051 ADDVI----------------------FEDAITNVYFILINQNALKSTMLDWIEKWQALNIKMLL 1093
             .::|                      :|:.|.::.....|:.||:..:...|:.|....:.::|
Human  1087 -QEIIGKSVPLDKNCKVENLLALKMFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLPLIL 1150

  Fly  1094 DH------------------------------GSNLMGAVYRYMRRNERNVMKVPRTI------- 1121
            .|                              ||..:|.:...:...::|:.....|:
Human  1151 HHTEIYSIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQ 1215

  Fly  1122 ----------------RETVAAKQLF-------EKLLKDVPVKQSAFTPMLELFVL-------LH 1156
                            |:..|..:||       :|::..:..||:|........||       :|
Human  1216 RNWLYLEPVFHSSEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIH 1280

  Fly  1157 KYQVKLSEETFEQVMGLETAWLHYLQVLEEADEMLDNEDSEA-KLLLAKHGEKFKLIL 1213
            ...:|.|.|.:.:|..|.....::|...|..|.:.|:.:.|: :..|.|..|..|.:|
Human  1281 LEHIKKSLEDYLEVKRLIFPRFYFLSNAELLDILADSRNPESVQPHLVKCFENIKQLL 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9068	NP_611111.1	DHC_N1	212..784	CDD:462457	128/759 (17%)
DNAH14	NP_001354408.1	DHC_N2	989..1394	CDD:462462	59/351 (17%)
		DYN1	<1229..4210	CDD:227570	26/110 (24%)
		AAA_6	1527..1861	CDD:463697
		Dynein_C	4215..4612	CDD:465677