DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cato and NEUROD6

DIOPT Version :9

Sequence 1:	NP_477344.1	Gene:	cato / 36813	FlyBaseID:	FBgn0024249	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_073565.2	Gene:	NEUROD6 / 63974	HGNCID:	13804	Length:	337	Species:	Homo sapiens

Alignment Length:	108	Identity:	45/108 - (41%)
Similarity:	60/108 - (55%)	Gaps:	9/108 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IMEAQGQHTQPQTKRRSNSFTGSDG-------RKSSPEQTNLSPTVQKRRRQAANARERKRMNGL 119
            |..|.|:.|:.:.:.........:|       ||....:..|...  |.|||.||||||.||:||
Human    48 IKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERV--KFRRQEANARERNRMHGL 110

  Fly   120 NAAFERLREVVPAPSIDQKLSKFETLQMAQSYILALCDLLNNG 162
            |.|.:.||:|||..|..|||||.|||::|::||.||.::|..|
Human   111 NDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIG 153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cato	NP_477344.1	HLH	104..155	CDD:278439	32/50 (64%)
NEUROD6	NP_073565.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..82		6/33 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	80..86		2/5 (40%)
		bHLH_TS_NeuroD6_ATOH2	82..151	CDD:381565	36/70 (51%)
		Neuro_bHLH	153..272	CDD:403655	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940