DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cato and NEUROD4

DIOPT Version :9

Sequence 1:	NP_477344.1	Gene:	cato / 36813	FlyBaseID:	FBgn0024249	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_067014.2	Gene:	NEUROD4 / 58158	HGNCID:	13802	Length:	331	Species:	Homo sapiens

Alignment Length:	138	Identity:	47/138 - (34%)
Similarity:	72/138 - (52%)	Gaps:	26/138 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SPEWQFLDAAGGTQTELGPIMEAQGQHTQPQTKRRSNSFT---------------GSDGRKSSPE 92
            :|.|  :|...|:|.|:      :.:.::|.|....:|.|               |...::..|:
Human    17 TPSW--MDKGLGSQNEV------KEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPK 73

  Fly    93 QTNLSPTVQKR---RRQAANARERKRMNGLNAAFERLREVVPAPSIDQKLSKFETLQMAQSYILA 154
            :..::....:|   ||..||||||.||:|||.|.:.||.|:|..|..|||||.|||::|::||.|
Human    74 KKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWA 138

  Fly   155 LCDLLNNG 162
            |.::|..|
Human   139 LSEVLETG 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cato	NP_477344.1	HLH	104..155	CDD:278439	30/50 (60%)
NEUROD4	NP_067014.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80		12/70 (17%)
		HLH	88..144	CDD:238036	32/55 (58%)
		Neuro_bHLH	146..264	CDD:289310	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940