Protein Alignment cato and TWIST2

DIOPT Version :10

• Sequence 1: NP_477344.1
• Gene: cato / 36813
• FlyBaseID: FBgn0024249
• Length: 189
• Species: Drosophila melanogaster
• Sequence 2: NP_476527.1
• Gene: TWIST2 / 117581
• HGNCID: 20670
• Length: 160
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 109/572 - (19%)
• Similarity: 191/572 - (33%)
• Gaps: 177/572 - (30%)

  Fly    16 EADAPSDMKSP--------TKRT---PKRKAVEAFQKESEELLKSLGVSVDLEDGRRRTRSSARG 69
            :|:.|.....|        |||:   .:...:|.:.......:..|...||..||..:...|..|
Human    26 QAELPRSRSKPYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEG 90

  Fly    70 AT------PTTAAVTATPPSKRARGASTTPKRTEKSAEAEATPSKQQSPSSKSSTPKKRAIQAEP 128
            |:      ..|..:.||             ||.::..:|..| .:.|:....::.|      .||
Human    91 ASSIFIIDENTGDIHAT-------------KRLDREEQAYYT-LRAQALDRLTNKP------VEP 135

  Fly   129 RKLVVL----VDSELPK----EYTRERMAAKTEKMDTTTTATEAVAKSDSVEMKKEQEEEEKKAA 185
            ....|:    ::...||    .||     |...:|....|:...|..:|:     :.......|.
Human   136 ESEFVIKIQDINDNEPKFLDGPYT-----AGVPEMSPVGTSVVQVTATDA-----DDPTYGNSAR 190

  Fly   186 TT------EPAEKVEEKKEELATSTEEKQDEVEETKETPDTENKEEAKEEDKERKEEEEVTVAKD 244
            ..      :|...||.|...:.|:....                      |:|.|::..:.:
Human   191 VVYSILQGQPYFSVEPKTGVIKTALPNM----------------------DREAKDQYLLVI--- 230

  Fly   245 ADAAAPASDAPAKEETSQDKPPAEEKAMEVDTQDGGKAAEAVNDTHPKTESAAEAQSNEKETKDV 309
                      .||:...|:...:...::.|...|       |||..|:....: .|.|..|:..|
Human   231 ----------QAKDMVGQNGGLSGTTSVTVTLTD-------VNDNPPRFPRRS-YQYNVPESLPV 277

  Fly   310 VMEDVSVQ----EVGKVSEKEVEKVVEKE----VEKEQEKVTEKEQEKVVEKEVEKEVEKDAEKE 366
            ......::    ::|..:|.|. |:|:.:    .:...:|.|   ||.::  .::||::.:| |.
Human   278 ASVVARIKAADADIGVNAEMEY-KIVDGDGLGIFKISADKDT---QEGII--TIQKELDFEA-KT 335

  Fly   367 AQKVEIESNGSVVDATV-------DTTTPK---KEVSEP-----------AAAATAGGVNSAESA 410
            :..:.||:.....|...       ||||.|   ::|.||           .:.||..|......|
Human   336 SYTLRIEAANRDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGHIIGTVA 400

  Fly   411 NHENAKESTPKKASDDEVTE-----TVDASK---APAESNEKVTN------------PEPK---- 451
            .|:....::|.:.|.|..|:     .:||:.   ..|:|.::.||            ..|.
Human   401 AHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAVHNITVLAMESQNPSQVGR 465

  Fly   452 ---------VNEDVAAPAIGPDTEQKQTETKDVTANNITTKDVDVEKVKASN 494
                     :|::  ||....|.|  .|..::.....:..|...|:|.:.||
Human   466 GYVAITILDINDN--APEFAMDYE--TTVCENAQPGQVIQKISAVDKDEPSN 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cato	NP_477344.1	bHLH_TS_ATOH1_like	104..159	CDD:381436	12/62 (19%)
TWIST2	NP_476527.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		7/36 (19%)
		bHLH_TS_TWIST2	51..132	CDD:381543	17/94 (18%)