DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33017 and GPATCH8

DIOPT Version :9

Sequence 1:	NP_001286483.1	Gene:	CG33017 / 36811	FlyBaseID:	FBgn0053017	Length:	1630	Species:	Drosophila melanogaster
Sequence 2:	XP_011522859.1	Gene:	GPATCH8 / 23131	HGNCID:	29066	Length:	1531	Species:	Homo sapiens

Alignment Length:	1285	Identity:	241/1285 - (18%)
Similarity:	428/1285 - (33%)	Gaps:	381/1285 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 VPPAHGNYYQPH-----------HVDQNARNYSRSAPPDAPYDETVYLNDYGRSMYPEPQHVYCI 512
            :||||.. .:|:           .:|.:...:.::||            :..:...|:|:.  ||
Human   426 IPPAHCK-VKPNFPFLLFMRASEQMDGDNTTHPKNAP------------ESKKGSSPKPKS--CI 475

  Fly   513 NAEDAPTDVWVQAQSPDASTNPSQMPMAPPSKSWNQEKATRPLQPAKKGNATAPPPQDPMKTYSS 577
            .|          |.|..|....|::...|...|     .|.|.:|..|..|        .|....
Human   476 KA----------AASQGAEKTVSEVSEQPKETS-----MTEPSEPGSKAEA--------KKALGG 517

  Fly   578 KAS--ALEKHEQSGQNLIPTEQTKSMPEDFQSKTVQKSNDQGERSNLGRR--------------- 625
            ..|  :||.|.|.      ..:|: |.|...||....:...|:.|..|.:
Human   518 DVSDQSLESHSQK------VSETQ-MCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDES 575

  Fly   626 ---SYGSE-------------SSN--YNQGRIQNEERSRRDGPDRP-----DQKKYICEDDNCPV 667
               .:.||             |.|  |...::...:.:|..|.::|     ..|.::...|....
Human   576 TALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEP 640

  Fly   668 NKRHQ--NEERPSKRRSRKD-------------DEVGNNHNSNYEDS----PPPRRRKDNADEAK 713
            ||..:  .|:.......|.|             .|.|.:|.|..||:    |..:.|...:...|
Human   641 NKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHK 705

  Fly   714 NQKVFQLQTDDSQLMACPAYDRRDPKECPHLKCPSPKHREEGVARNSRNRDYEENNERTSKSRRS 778
            .:|                   :..|...|.:    ||:.:...::|:....|::.:|..:.|:.
Human   706 KKK-------------------KHKKSSKHKR----KHKADTEEKSSKAESGEKSKKRKKRKRKK 747

  Fly   779 SPLRNTYNEEEQQAPRERSSSHGREDNFRTKRKSNEETKRSKRRSDEICNDETCPFGVFTSRQN- 842
            :  :::...:.::.|:......|.....|.:|::.::::|....::|..:.:....|..:|.|:
Human   748 N--KSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDH 810

  Fly   843 ---KYQSE----RRTRNSGENEYSRHGNGTNPRSKRRDNDNPCNNDTCPYADSLEINMARSRKHS 900
               |::.|    ...|.:|....||..:.:.|.|...|:|:..::              |..:.|
Human   811 GGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSH--------------RLHQKS 861

  Fly   901 DRSYSKENDEEEKIARRYRSESSPRRRSRENDDYEDTAKSYRRESDKYRKPRREDPDYDSDYNEY 965
            ...||:|.:||:..:...||.|   |..|.:..:..:.:||...||.           .||.:.|
Human   862 PSQYSEEEEEEDSGSEHSRSRS---RSGRRHSSHRSSRRSYSSSSDA-----------SSDQSCY 912

  Fly   966 G-QRRYNNRYSDNYPEYRTSIGKPNKYSKREHRNSPSRYAEGPREDYRTEYKYRNHGNTLEDCY- 1028
            . ||.|::   |:|.:|.   .:..::|||.|.:..|.||.......|.:|      ::.:|.|
Human   913 SRQRSYSD---DSYSDYS---DRSRRHSKRSHDSDDSDYASSKHRSKRHKY------SSSDDDYS 965

  Fly  1029 --CDDFESDEYDANNPYDAYPRRENATVRNRNAPMEYNGRESSRRPKRPSKYDNSESEDMPYNKS 1091
              |....|                    |:|:...|   |..||...|.|....|.|:
Human   966 LSCSQSRS--------------------RSRSHTRE---RSRSRGRSRSSSCSRSRSK------- 1000

  Fly  1092 ERIDTNRNRNADNITTKRNPSYSREADLYDSAEDDCFCSDEEIPHATANRNSRSSRNDRRSSGLA 1156
                 .|:|:....:.:|:.||||:                         .|||:|:..:.|
Human  1001 -----RRSRSTTAHSWQRSRSYSRD-------------------------RSRSTRSPSQRS--- 1032

  Fly  1157 NNGKQDRSRRSETTESRRNESRNSDRA------------------PETRPSNR--DIKEIQNPNN 1201
              |.:.||...|:.|.|.:..|:..|:                  |..:...|  |.|....|:
Human  1033 --GSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPS- 1094

  Fly  1202 AYDIDIKNKTHDVGEYSKNDNRNANHNSIVSPVSDDDCICDVESDPKDPKSTVPEK----RNQAG 1262
                  :|.....|..|:.|....:.||:.:.:    .:..::|...:.|.:|.|:    .|:||
Human  1095 ------QNSNIGTGRGSEGDCSPEDKNSVTAKL----LLEKIQSRKVERKPSVSEEVQATPNKAG 1149

  Fly  1263 S---------ICINLSTSVEDKEHKMQSFGKAKKTAEPTVMVPKSLDASNRLREQKEGKTK---- 1314
            .         ....|..|:.:|. .:...||...|.:|.....:|  ...|..||::.:|:
Human  1150 PKLKDPPQGYFGPKLPPSLGNKP-VLPLIGKLPATRKPNKKCEES--GLERGEEQEQSETEEGPP 1211

  Fly  1315 -------------------LVTTSENQSSSAKKNIRAKTGISPRVQSRSTSPVRQTGA---TKIQ 1357
                               |:.....:|.|.              ::.:..||...|.   :...
Human  1212 GSSDALFGHQFPSEETTGPLLDPPPEESKSG--------------EATADHPVAPLGTPAHSDCY 1262

  Fly  1358 PGEPVKRRTTTRSPSQNAAKRTMETHA----AANSKLPF--DLNSAAYFICKLQD------EGNN 1410
            ||:|.........||......::::.:    ..:|.||.  ||.....:.....|      :|..
Human  1263 PGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAE 1327

  Fly  1411 HQYLLVVPKKPIG-TPDGHRKAPGQESVKQLHCPRQCSGFQSMSWDDSATATRSQPPLQSQASGG 1474
            ...|..:..:||. ||:...|....:...|.|..:|....|..::..||....:.|.||..
Human  1328 DASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPI---- 1388

  Fly  1475 LSILGSFRIPPVLASTALGIIKEHLHRNTVLQKPDAREREA--LYPPRRMRRILMTRPISRPRRP 1537
                 ..:.|...::|::..:     ::.:||...|....|  ::|....:.:.....|.:|...
Human  1389 -----HIQQPATASATSITTV-----QHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLT 1443

  Fly  1538 VLRPSHKANAPILKENRTLLLTSNPFRNLSFSDHNREVIVLHPPDPGFRP 1587
            .:..||..:: |:..:....|.|:|...:..|       .:||....|.|
Human  1444 PISLSHLTHS-IIPGHPATFLASHPIHIIPAS-------AIHPGPFTFHP 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG33017	NP_001286483.1	MADF_DNA_bdg	21..106	CDD:287510
GPATCH8	XP_011522859.1	G-patch	40..82	CDD:279867
GPATCH8	XP_011522859.1	zf-C2H2_jaz	136..163	CDD:288983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7816
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950