Protein Alignment Khc and KIF3B

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_004789.1
• Gene: KIF3B / 9371
• HGNCID: 6320
• Length: 747
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 254/787 - (32%)
• Similarity: 389/787 - (49%)
• Gaps: 141/787 - (17%)

  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG---------KVYLFDKVFKP 61
            ::.:.:|::||.|.||:|..|:.|....||..  :|:...:|:..         |.:.||.|:..
Human     3 KLKSSESVRVVVRCRPMNGKEKAASYDKVVDV--DVKLGQVSVKNPKGTAHEMPKTFTFDAVYDW 65

  Fly    62 NASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHI 126
            ||.|.::|:|..:.:|..||.|:||||||||||.:|||:||||:.||..|:|:||...:.||.||
Human    66 NAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHI 130

  Fly   127 YAMEVNLEFHIKVSYYEIYMDKIRDLL--DVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEV 189
             :...|.::.::.||.|||.::|||||  |.:| .|.:.|..:...|||..:.....|.:::..|
Human   131 -SRSQNQQYLVRASYLEIYQEEIRDLLSKDQTK-RLELKERPDTGVYVKDLSSFVTKSVKEIEHV 193

  Fly   190 IEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENL----ENQKKLSGKLYLVDLAGSEKVSKTGA 250
            :..|..||.:..|||||||||||::|:|.::...:    ||..:: |||.||||||||:.:||||
Human   194 MNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRV-GKLNLVDLAGSERQAKTGA 257

  Fly   251 EGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASF 315
            :|..|.||..||.||||||||||||.||..||||||||||||:||:||||||:|.:|....|||:
Human   258 QGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASY 322

  Fly   316 NESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWR--- 377
            |..||.:||.:..|||.:||...|||: ..:...|.::   |:.||||.::||..|...:.|
Human   323 NVEETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQ---EEIARLKAQLEKRSIGRRKRREKR 383

  Fly   378 --------AGETVK------AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSAS 428
                    .||..:      .||..:.:|........||:|              :.|:
Human   384 REGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIE--------------KRAI------ 428

  Fly   429 VAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVM------------------EQEEL 475
              |.:.:.:|.|..||.::.:.|.|::.::...||.|..::.                  ||:::
Human   429 --VEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKI 491

  Fly   476 IANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQ 540
            :...|:|....:.....|||:.||..||..       ||...|....||:|.|.|.:..|..:||
Human   492 LEQKRQEIAEQKRREREIQQQMESRDEETL-------ELKETYSSLQQEVDIKTKKLKKLFSKLQ 549

  Fly   541 QKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDAS 605
                   |...|:..|::....:::.:.:....|.|:| ::...|.  |:.|.|:       :.|
Human   550 -------AVKAEIHDLQEEHIKERQELEQTQNELTREL-KLKHLII--ENFIPLE-------EKS 597

  Fly   606 KVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQH------- 663
            |:     |.|.|..:.:...|  ....:.:|.||. ..:.:|.    :| |:..:|||
Human   598 KI-----MNRAFFDEEEDHWK--LHPITRLENQQM-MKRPVSA----VG-YKRPLSQHARMSMMI 649

  Fly   664 --EARMKSLQESMREAENKKRT------------LEEQIDSL--REECAKLKAAEHVSAVNAEEK 712
              |||.::....:.|.:...||            ::..:|:.  .|:..::.|:...|..|.:.|
Human   650 RPEARYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSK 714

  Fly   713 QRAEELR 719
            .|.:..|
Human   715 ARPKSGR 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	159/337 (47%)
		Smc	<341..>807	CDD:440809	91/437 (21%)
		Khc_CBD_cc	856..925	CDD:467880
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	159/336 (47%)
		Smc	<355..>581	CDD:440809	57/265 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		6/37 (16%)
		Globular	580..747		34/165 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..747		6/23 (26%)