DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and ZCF125

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_564744.1	Gene:	ZCF125 / 842245	AraportID:	AT1G59540	Length:	823	Species:	Arabidopsis thaliana

Alignment Length:	965	Identity:	269/965 - (27%)
Similarity:	407/965 - (42%)	Gaps:	211/965 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCIS--------IAGKVYLFDKVFKPNASQEK 67
            :.|.|..|.||  .:.|...|.:      .||:|.||        |....:.||.||..:::...
plant     2 EKICVAVRVRP--PAPENGASLW------KVEDNRISLHKSLDTPITTASHAFDHVFDESSTNAS 58

  Fly    68 VYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVN 132
            ||....|.|:...:.|:|||.|||||||||||.||   .|.....|||.|.|.|:|..|: |..:
plant    59 VYELLTKDIIHAAVEGFNGTAFAYGQTSSGKTFTM---TGSETDPGIIRRSVRDVFERIH-MISD 119

  Fly   133 LEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNR 197
            .||.|:|||.|||.::|.|||.|....|.:||...|..:|.|..|..||..|.:.::|:.|:.||
plant   120 REFLIRVSYMEIYNEEINDLLAVENQRLQIHEHLERGVFVAGLKEEIVSDAEQILKLIDSGEVNR 184

  Fly   198 HIAVTNMNEHSSRSHSVFLINVKQENLENQKKLS---GKLYLVDLAGSEKVSKTGAEGTVLDEAK 259
            |...||||.||||||::|.:.::....:|....:   ..|.||||||||:::||||.|..|.|.|
plant   185 HFGETNMNVHSSRSHTIFRMVIESRGKDNSSSDAIRVSVLNLVDLAGSERIAKTGAGGVRLQEGK 249

  Fly   260 NINKSLSALGNVISALADGNK--THIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKS 322
            .|||||..|||||:.|:|..|  .||||||||||||||.:|||||:|.|:...:|...:..|:|.
plant   250 YINKSLMILGNVINKLSDSTKLRAHIPYRDSKLTRILQPALGGNAKTCIICTIAPEEHHIEESKG 314

  Fly   323 TLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQ 387
            ||.|..|||.:.|...|||.||.....:|               :|||||..|.:
plant   315 TLQFASRAKRITNCAQVNEILTDAALLKR---------------QKLEIEELRMK---------- 354

  Fly   388 INMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKD 452
                 |..:....||.|                 :.|:|     |:..:...|||||..||   :
plant   355 -----LQGSHAEVLEQE-----------------ILNLS-----NQMLKYELECERLKTQL---E 389

  Fly   453 EEINQQSQYAEQLKEQVMEQEEL---IANARREYETLQSEMARIQQENESAKEEVKEVLQALEEL 514
            ||..:|.:....:|||.|:.|.|   :.|:  :::..|||...|.::.......|
plant   390 EEKRKQKEQENCIKEQQMKIENLNNFVTNS--DFKRNQSEDFIISRKTPDGLCNV---------- 442

  Fly   515 AVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLG 579
                        |...|:..........:|...|.|.....|.|.|.            ::..||
plant   443 ------------NDTSDVPGTPCFKSASRSFVVARSNNYSGLSDFSP------------MVHSLG 483

  Fly   580 EVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNK 644
            :|    |..::.:.|....:|..|    :..||.|   :....|........|         ..:
plant   484 DV----ADEDTWMKLNKGFVADLD----QIQFTPA---VKCQPTPLSIATTEC---------PRE 528

  Fly   645 KISEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNA 709
            ..||.|......:||.::::    |||....|.......|.:::..|::|...:|
plant   529 NHSEVEDLKSRIQLLTNEND----SLQVKFNEQVLLSNNLMQEMSELKQETLTVK---------- 579

  Fly   710 EEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEK 774
                   |:.:.....:...::.:       :|.|...:..:.:.:.....|||...::|.....
plant   580 -------EIPNRLSESVANCKDVY-------KDVIVTMKSLITDKESPTANLLLGTTEITTSLLA 630

  Fly   775 VRQE------DAEKS-SELQNIILTNERREQARKDLKG-----LEDTVAK-ELQTLHNLRKLFVQ 826
            ..:.      |.:|: |.:.:.:  ::..|..|.:||.     |.|..|| |....||
plant   631 TLETQFSMIMDGQKTGSSIDHPL--SDHWETLRVNLKNTTTLLLSDAQAKDEFLNSHN------- 686

  Fly   827 DLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNL---DQLTKV----HKQLVRDNADLRCELPK 884
                :.::....||.:.....:..|::.:.||..|   .||.:.    |::|:::...|:.|...
plant   687 ----KGQETAALEEKKLKSELIIIKERYNELEKELCLDKQLLEASRESHEKLIKEVQFLKEERDS 747

  Fly   885 LEKRLRCTMERVKALETALKEAKEGAMRD-------RKRYQYEVDRIKEAVRQKH 932
            |::::..:.:|::.:.:    .||.|::|       ||..:.|:..|..|...:|
plant   748 LDRKISQSTQRLRVIAS----DKENALKDLNVEVKRRKDMEEEIKHISIAFATRH 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	149/334 (45%)
		KISc	12..340	CDD:214526	150/340 (44%)
		Apolipoprotein	595..744	CDD:279749	22/148 (15%)
ZCF125	NP_564744.1	KISc_CENP_E	3..325	CDD:276825	149/333 (45%)
		Kinesin	9..325	CDD:278646	147/327 (45%)
		Cortex-I_coil	711..787	CDD:286397	17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910