DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc and AT4G24170

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001320052.1	Gene:	AT4G24170 / 828517	AraportID:	AT4G24170	Length:	1004	Species:	Arabidopsis thaliana

Alignment Length:	1024	Identity:	249/1024 - (24%)
Similarity:	431/1024 - (42%)	Gaps:	208/1024 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDSIKVVCRFRPLNDSEEKAGSK----------FVVKFPNNVEENCISIAGKVYLFDKVFKPNAS 64
            |:.|.|..|.||||:.|:....:          .:.||.|..:::.       |.|||||.....
plant     4 EEKILVSVRVRPLNEKEKTRNDRCDWECINDTTIICKFHNLPDKSS-------YTFDKVFGFECP 61

  Fly    65 QEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAM 129
            .::||::.||.:...||:|.|.:||||||||||||:||         .||....::|||.:|...
plant    62 TKQVYDDGAKEVALCVLSGINSSIFAYGQTSSGKTYTM---------SGITEFAMDDIFAYIDKH 117

  Fly   130 EVNLEFHIKVSYYEIYMDKIRDLL-DVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEG 193
            :...:|.:|.|..|||.:.:|||| :.|...|.:.:|..|...|:...|..:.....:.|::...
plant   118 KQERKFTLKFSAMEIYNEAVRDLLCEDSSTPLRLLDDPERGTVVEKLREETLRDRSHLEELLSIC 182

  Fly   194 KSNRHIAVTNMNEHSSRSHSVFLINV----KQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTV 254
            ::.|.|..|::||.|||||.:..:.:    :|.:.|:...|:..:..|||||||:.|:|.:.|:.
plant   183 ETQRKIGETSLNEISSRSHQILRLTIESSSQQFSPESSATLAASVCFVDLAGSERASQTLSAGSR 247

  Fly   255 LDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESE 319
            |.|..:||:||..||.||..|:.|...||||||||||||||.||||||||.|:...|||..:..:
plant   248 LKEGCHINRSLLTLGTVIRKLSKGKNGHIPYRDSKLTRILQNSLGGNARTAIICTMSPARSHLEQ 312

  Fly   320 TKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWR------- 377
            :::||.|...||.|.....||  |...|               |..|::|:.||||..
plant   313 SRNTLLFATCAKEVTTNAQVN--LVVSE---------------KALVKQLQRELARMENELKNLG 360

  Fly   378 ---AGET---------------VKAEEQIN----MEDLMEASTPNLEVEAAQTAAAEAALAAQRT 420
               |..|               .|.||||:    ..|:.::...||....|:..::.:::.::|.
plant   361 PASASSTSDFYALMLKQKEELIAKMEEQIHELKWQRDVAQSRVENLLKSTAEERSSSSSMDSRRR 425

  Fly   421 ALANMSASVAVNEQARLATEC--ERLYQQ------LDDKDEEI---NQQSQYAEQLKEQVMEQEE 474
            .::..|...   ::.|:....  ..||..      |||...:.   |...::.|..:....|.|:
plant   426 RISYDSTDF---DEPRMLNNLGKSNLYSPDEDGFLLDDTTPQFPGHNLHDKWEEMAQSTTQEPED 487

  Fly   475 LIANAR-REYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDID----- 533
            .....| .|..:.::|..:||...:...|:        :|...||:.:..:.|:..|:||
plant   488 ACKEVRCIEVNSGEAERVQIQDSLDDIVEK--------KEYEQNYESQKDDADSSIKNIDMELSL 544

  Fly   534 ----ALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDL 594
                ...:.:..|:.:.:...||....|...|.:|:   ||...|.||:.|......|.|.....
plant   545 YTKPEAEDGVSVKKLIEDVQETEQSVEKQKQSPKKE---EMEQYLSRDMSEQVTKSLPEEEQCVQ 606

  Fly   595 KMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLL 659
            :..|....:|..|        |.|:|:: |::...|     ..::.|:.|.:|..::|| :..|.
plant   607 EYGAYDKLEAQDV--------LTINKLE-ESQQTEQ-----SVEKEDTKKNLSSKKEDL-KQNLS 656

  Fly   660 ISQHEARMKS---------LQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRA 715
            :.|.|...||         :.|...:.:|....|::::..::      |..|:..::.:.|::::
plant   657 MDQSEQLYKSPPEDEKCVEVYEGSDKDDNTYEALKKKVKEMQ------KTIEYFMSIQSAEEKQS 715

  Fly   716 EELRSMFDS----QMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVR 776
            .....:.|:    :..::|.:.:.:.:.|..:.||.......:.:.......:...::.|.:.::
plant   716 PSFNIIDDTLSPGEYFKMRRSRSCRENLLFTKAAAAAASRGFIFETTNTSFDSDITVSMDAQSIK 780

  Fly   777 QEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEES 841
            ..|.|.||...:..:...|....:......:||..|.::                       .|:
plant   781 DSDTETSSSSFHEFMAGLRERTMQHHSTHSDDTDTKTMK-----------------------PEN 822

  Fly   842 EEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKR---------------LRC 891
            .:|||   :|.:....::.:.:|.:|            |.:|.:.:.               :..
plant   823 TDDGG---EKTEFERQQSQIIELWQV------------CNVPLVHRTYFFLLFKGDPSDFVYMEV 872

  Fly   892 TMERVKAL----ETALKEAKEGAMRDRKRYQYEV-----DRIKEAVRQK 931
            .:.|:..|    ||:.|:..:...|:|:....::     .:.||.|.:|
plant   873 ELRRLSFLKDSTETSRKQTAKAVTREREWLAKQIPNKFGKKEKEEVYKK 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	129/337 (38%)
		KISc	12..340	CDD:214526	129/342 (38%)
		Apolipoprotein	595..744	CDD:279749	27/161 (17%)
AT4G24170	NP_001320052.1	KISc_CENP_E	6..326	CDD:276825	128/335 (38%)
		PTZ00121	<473..724	CDD:173412	54/282 (19%)
		DUF3490	831..980	CDD:403272	15/103 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910