DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and AT3G10180

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_187629.3	Gene:	AT3G10180 / 820180	AraportID:	AT3G10180	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1167	Identity:	313/1167 - (26%)
Similarity:	494/1167 - (42%)	Gaps:	309/1167 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSIKVVCRFRPLNDSEEKAG----SKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNE 71
            :.|.|..|.|||:..:.|..    |...:..||:        :...:.||::|:.:....:||..
plant     2 ERIHVSVRARPLSSEDAKTSPWKISSDSIFMPNH--------SSLAFEFDRIFREDCKTVQVYEA 58

  Fly    72 AAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFH 136
            ..|.||:..:.|:|||:||||||:|||||||.   |..::.|:||..|:|:|:.|| .:.:.||.
plant    59 RTKEIVSAAVRGFNGTVFAYGQTNSGKTHTMR---GSPIEPGVIPLAVHDLFDTIY-QDASREFL 119

  Fly   137 IKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAV 201
            :::||.|||.:.|.|||......|.:||:..:..:|.|..|..|:||:.|.|::|.|:|:|||..
plant   120 LRMSYLEIYNEDINDLLAPEHRKLQIHENLEKGIFVAGLREEIVASPQQVLEMMEFGESHRHIGE 184

  Fly   202 TNMNEHSSRSHSVFLINVKQENLENQKKLSGK-------------LYLVDLAGSEKVSKTGAEGT 253
            ||||.:|||||::|.:.:     |:::|:..:             |.||||||||:.:||||||.
plant   185 TNMNLYSSRSHTIFRMII-----ESRQKMQDEGVGNSCDAVRVSVLNLVDLAGSERAAKTGAEGV 244

  Fly   254 VLDEAKNINKSLSALGNVISALADGNKT---HIPYRDSKLTRILQESLGGNARTTIVICCSPASF 315
            .|.|..:|||||..||.||..|::|.:|   |:||||||||||||.:|||||.|.|:...:.|..
plant   245 RLKEGSHINKSLMTLGTVIKKLSEGVETQGGHVPYRDSKLTRILQPALGGNANTAIICNITLAPI 309

  Fly   316 NESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKE-KEKNARLK-GKVEKLEIELARWRA 378
            :..||||:|.|..||..|.|...|||.||.....:|.:|| :|..::|| ...:..|.|:...|
plant   310 HADETKSSLQFASRALRVTNCAHVNEILTDAALLKRQKKEIEELRSKLKTSHSDHSEEEILNLR- 373

  Fly   379 GETVKAE---EQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVN-------- 432
            ...:|:|   |:|.:|         ||.|....|..|..|..|...:.|:|:.|.::
plant   374 NTLLKSELERERIALE---------LEEEKKAQAQRERVLQEQAKKIKNLSSMVLLSNRDEKREQ 429

  Fly   433 ------------------------------------EQARLATEC-----------ERLYQQLDD 450
                                                |.||...|.           |.|| .:::
plant   430 DHFKKGKRRDTWCIGKLSRDSTSEDQSNVLSRGSSLESARSERETGPLLPFSELVNEPLY-NINE 493

  Fly   451 KDEE-----------------INQQSQYAEQLKEQ---VMEQEELIANARREYET--LQSEMARI 493
            :||:                 :|..|:....:|::   |:|.|  :...:||||.  ||.|..||
plant   494 EDEDSIEGTLEDSVLPDPCALVNVTSRKKPSIKQKNPVVVENE--LDRIQREYEALLLQYETERI 556

  Fly   494 QQE----------------------------NESAKEEV-----KEVLQALEELAVNYDQKSQEI 525
            ..|                            |...:|.|     .|.:..:::|....:....|.
plant   557 ISEIQIECLKVKLGEDGLSGDAKCKQSEVVGNVHCEEHVVNLRDPEAILLIKQLQEKINMLELEK 621

  Fly   526 DNKNKDIDAL-----------NEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLG 579
            .:.|:::|.|           .|:..:.|...:||..|.|..::....::..:.:::......|.
plant   622 SSSNRNLDDLVMVATEQNICAREKFAEIQEEIHAAREEAQVAREQLVSKESEVIDVINENFNSLV 686

  Fly   580 EVGQAIAPGESSIDLKMSALAGTDASKVEE-------------DFTMARLFISKMKTEAKNIAQR 631
            .|...|...||... |..|...|.:|.:.|             |||   ||:.:...:..::
plant   687 NVATEIEVLESEFQ-KYKASVETISSVMNEGLQDFAFFSPLIHDFT---LFVRQSSEQHDSL--- 744

  Fly   632 CSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRT----LEEQIDSLR 692
            .::.:|.|:...||:.:.|.:    :||:.:..|.::|..|.:.:...|..|    |.|..:|.|
plant   745 INSYQTVQSSLKKKVLDVENE----KLLLQEQCAGLQSQIEELNQEAQKHETSLKMLSEHHESER 805

  Fly   693 E------ECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEI---AAKQ 748
            .      ||.:.......|:..|:||   |.||..|:....:|::..::..:.::|:.   |.|.
plant   806 SDLLSHIECLEKDIGSLSSSSLAKEK---ENLRKDFEKTKTKLKDTESKLKNSMQDKTKLEAEKA 867

  Fly   749 HEMDEMKDVH-QKLLL-----------------------AHQQMTADY----------------- 772
            ....|:|.:| ||.||                       |:|.:..::
plant   868 SAERELKRLHSQKALLERDISKQESFAGKRRDSLLVERSANQSLQEEFKQLEVLAFEMETTIASL 932

  Fly   773 -EKVRQEDAEKSSEL-------QNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDL- 828
             |::..|..||...|       ..|....|:.|.:...|:.|::.|. ||:|     :|.|...
plant   933 EEELAAERGEKEEALCRNDGLGSEITDLTEKLEHSNTKLEHLQNDVT-ELKT-----RLEVSSSD 991

  Fly   829 QQRIRKNV--VNEESEEDGGSLAQ-----------------------KQKISFLEN-NLDQLTKV 867
            ||::..||  :.||.||....||.                       ::||...:| .::.|:|.
plant   992 QQQLETNVKQLLEEKEELAMHLANSLLEMEEEKAIWSSKEKALTEAVEEKIRLYKNIQIESLSKE 1056

  Fly   868 HKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVR 929
            ..:..::....|.|...|..||||:.|..       |:.||.::..    ..|:||:.:.:|
plant  1057 MSEEKKELESCRLECVTLADRLRCSEENA-------KQDKESSLEK----SLEIDRLGDELR 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	142/341 (42%)
		KISc	12..340	CDD:214526	144/347 (41%)
		Apolipoprotein	595..744	CDD:279749	38/171 (22%)
AT3G10180	NP_187629.3	KISc_CENP_E	4..327	CDD:276825	142/339 (42%)
		Kinesin	9..324	CDD:278646	138/331 (42%)
		Tropomyosin	829..1065	CDD:278679	50/244 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910