DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and kif5ab

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_009301044.1	Gene:	kif5ab / 799274	ZFINID:	ZDB-GENE-110510-3	Length:	1050	Species:	Danio rerio

Alignment Length:	979	Identity:	527/979 - (53%)
Similarity:	699/979 - (71%)	Gaps:	70/979 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYN 70
            :|.||.:|:|:|||||||.||...|.||:..|..   ::.:.|||:.|:|||||..|.:||:|||
Zfish     3 DISAECNIRVLCRFRPLNQSEILRGDKFMPTFQG---DDTVIIAGRSYVFDKVFPTNCTQEQVYN 64

  Fly    71 EAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEF 135
            ..|:.||.|||.|||||||||||||||||:||||.:.|:..:||||||..|||||||.|:.||||
Zfish    65 TCAQQIVKDVLDGYNGTIFAYGQTSSGKTYTMEGKLHDANGRGIIPRIAEDIFNHIYTMDENLEF 129

  Fly   136 HIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIA 200
            ||||||:|||||||||||||:|.||||||||||||||||.|||||||||:|.::|:|||:|||:|
Zfish   130 HIKVSYFEIYMDKIRDLLDVTKTNLSVHEDKNRVPYVKGCTERFVSSPEEVMDLIDEGKANRHVA 194

  Fly   201 VTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSL 265
            |||||||||||||:||||:|||::|.::||.|||||||||||||||||||||.||||||||||||
Zfish   195 VTNMNEHSSRSHSIFLINIKQEHVETEQKLCGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSL 259

  Fly   266 SALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRA 330
            |||||||||||:|.|||:||||||:|||||:|||||.|||:.|||||:::|::||||||.||:||
Zfish   260 SALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTMFICCSPSAYNDAETKSTLMFGQRA 324

  Fly   331 KTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLME 395
            ||:.|...||.|||||:|||:||||||||..||..:::||.||..||.||:|
Zfish   325 KTIMNSASVNLELTAEQWKRKYEKEKEKNKDLKESMQRLEAELNHWRNGESV------------- 376

  Fly   396 ASTPNLEVEAAQTAAAEAALAAQRTALANMS--ASVAVNEQ--ARLATECERLYQQLDDKDEEIN 456
                   |.....:.||..: .:.||:.|.|  .:..:.||  :|...|.::||:||||||:|||
Zfish   377 -------VLITPVSPAECDV-TEDTAVDNQSHGQTELIPEQHNSRYEEEIQQLYRQLDDKDDEIN 433

  Fly   457 QQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQK 521
            .|.|..|:||||:::||||:|.||.:.|.:|.::.|:|.::||:|.||:||||||||||::||.|
Zfish   434 LQCQLVEKLKEQMLDQEELLACARADLERVQCDVRRLQADSESSKLEVQEVLQALEELALSYDHK 498

  Fly   522 SQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIA 586
            |.|..:.::....|.|||....|...:..::..:|::::..|:|||||:|..|::||.:....:.
Zfish   499 SLEAQDNSRHNRRLTEELAHTTSALLSLESDFSRLQEVNGQQRKRITEVLNTLVKDLNDFSFILG 563

  Fly   587 PGESSIDLKM-SALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYE 650
            .|    ||:: |.|:|.    :||::.:..:::||:|:|.|.:.:||..:|:.|.|.::|:.|..
Zfish   564 NG----DLRLPSELSGV----LEEEYAVVCVYMSKVKSELKTLVKRCRQLESLQTDCHRKMEETG 620

  Fly   651 KDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHV--SAVNAEEKQ 713
            ::|...:||||||||:::||.|.|:..|.|||.|||..|.|.||.|||:..|.:  ..::.:|..
Zfish   621 RELSSCQLLISQHEAKIRSLTEYMQNMELKKRQLEENYDCLSEELAKLQNTESILDRPLDTDESV 685

  Fly   714 RAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQE 778
            ..:..::: |.:.:..||...:|:..|||:|..||..:||:.|.:|:|.|..:|::.::..::..
Zfish   686 NVKSHKAV-DQKSEVQREPQHKQLGRLRDDINHKQKIIDELTDDNQRLDLQLEQLSVEFSVLKSR 749

  Fly   779 DAEKSSELQNIILTNERREQARKDLKGLEDTV---------------------------AKELQT 816
            :.|||.:|:.:...:||:||.|:|:||||:||                           |:||||
Zfish   750 EHEKSRQLEELRYLHERQEQTRQDMKGLEETVVSAYRKYDISNDNNNGVYDRPAHFSLKARELQT 814

  Fly   817 LHNLRKLFVQDLQQRIRKNVVNE-ESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRC 880
            ||||||||||||..|::::  :| :.::..|...|||||||||||||||||||||||||||||||
Zfish   815 LHNLRKLFVQDLTARVKRS--SELDPDDSSGCSTQKQKISFLENNLDQLTKVHKQLVRDNADLRC 877

  Fly   881 ELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKP 945
            ||||||||||.|.|||:|||.||:|||||||:||:|||.||:|||:.:|.::..||...|.||||
Zfish   878 ELPKLEKRLRSTAERVRALEEALREAKEGAMKDRRRYQQEVERIKDVMRSRNPFRRPQAALIAKP 942

  Fly   946 IRSG 949
            ||.|
Zfish   943 IRPG 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	238/322 (74%)
		KISc	12..340	CDD:214526	239/327 (73%)
		Apolipoprotein	595..744	CDD:279749	53/151 (35%)
kif5ab	XP_009301044.1	KISc_KHC_KIF5	7..327	CDD:276820	238/322 (74%)
		KISc	9..334	CDD:214526	239/327 (73%)
		DUF2570	847..964	CDD:305162	78/100 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596599
Domainoid	1	1.000	491	1.000	Domainoid score	I362
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.610